ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	BEN	Cell Line	LUNG	NP_001157	c.1082C>G	p.S361*	CCLE	NP	NP
2	EN	Cell Line	ENDOMETRIUM	NP_001157	c.1318_1319insA	p.E440fs	CCLE	NP	NP
3	EN	Cell Line	ENDOMETRIUM	NP_001157	c.1834A>G	p.T612A	CCLE	PASSENGER/OTHER	Possibly Damaging
4	HEC251	Cell Line	ENDOMETRIUM	NP_001157	c.252C>A	p.F84L	CCLE	PASSENGER/OTHER	Possibly Damaging
5	HEC50B	Cell Line	ENDOMETRIUM	NP_001157	c.592T>G	p.F198V	CCLE	PASSENGER/OTHER	Benign
6	HEC6	Cell Line	ENDOMETRIUM	NP_001157	c.1181C>T	p.P394L	CCLE	PASSENGER/OTHER	Possibly Damaging
7	HEC6	Cell Line	ENDOMETRIUM	NP_001157	c.322C>G	p.P108A	CCLE	PASSENGER/OTHER	Probably Damaging
8	HUG1N	Cell Line	STOMACH	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
9	IM95	Cell Line	STOMACH	NP_001157	c.1012C>T	p.R338*	CCLE	NP	NP
10	JHUEM7	Cell Line	ENDOMETRIUM	NP_001157	c.1702G>T	p.E568*	CCLE	NP	NP
11	KALS1	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
12	KASUMI6	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
13	KNS42	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
14	KURAMOCHI	Cell Line	OVARY	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
15	LU65	Cell Line	LUNG	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
16	MKN7	Cell Line	STOMACH	NP_001157	c.55_55delA	p.K19fs	CCLE	NP	NP
17	NCCSTCK140	Cell Line	STOMACH	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
18	NCIH1105	Cell Line	LUNG	NP_001157	c.1013G>A	p.R338Q	CCLE	PASSENGER/OTHER	Benign
19	NCIH2141	Cell Line	LUNG	NP_001157	c.638G>T	p.G213V	CCLE	PASSENGER/OTHER	Probably Damaging
20	NCIH650	Cell Line	LUNG	NP_001157	c.1026A>T	p.Q342H	CCLE	PASSENGER/OTHER	Possibly Damaging
21	QGP1	Cell Line	PANCREAS	NP_001157	c.1416G>T	p.L472F	CCLE	PASSENGER/OTHER	Probably Damaging
22	SKNMC	Cell Line	BONE	NP_001157	c.970G>T	p.V324L	CCLE	PASSENGER/OTHER	Benign
23	SNU1040	Cell Line	LARGE INTESTINE	NP_001157	c.1318_1319insA	p.E440fs	CCLE	NP	NP
24	SNU1197	Cell Line	LARGE INTESTINE	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
25	SNU466	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
26	SNU81	Cell Line	LARGE INTESTINE	NP_001157	c.1588G>T	p.E530*	CCLE	NP	NP
27	SNUC2A	Cell Line	LARGE INTESTINE	NP_001157	c.430G>C	p.E144Q	CCLE	PASSENGER/OTHER	Benign
28	018	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000227758	c.946T>C	p.W316R	COSMIC	NP	NP
29	018-0046-01TD	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000227758	c.946T>C	p.W316R	COSMIC	NP	NP
30	107529	Tumour	BREAST	ENST00000227758	c.605C>G	p.S202*	COSMIC	NP	NP
31	112313	Tumour	LUNG	ENST00000227758	c.956G>A	p.G319E	COSMIC	NP	NP
32	134427	Tumour	LUNG	ENST00000227758	c.555A>T	p.E185D	COSMIC	NP	NP
33	1604875	Tumour	UPPER AERODIGESTIVE TRACT	ENST00000227758	c.1468A>G	p.K490E	COSMIC	NP	NP
34	2334196	Cell Line	LUNG	ENST00000227758	c.638G>T	p.G213V	COSMIC	NP	NP
35	587222	Tumour	LARGE INTESTINE	ENST00000227758	c.235G>T	p.D79Y	COSMIC	NP	NP
36	587376	Tumour	LARGE INTESTINE	ENST00000227758	c.1266G>T	p.E422D	COSMIC	NP	NP
37	587376	Tumour	LARGE INTESTINE	ENST00000227758	c.1734A>C	p.E578D	COSMIC	NP	NP
38	8012788	Tumour	PANCREAS	ENST00000227758	c.1748T>A	p.F583Y	COSMIC	NP	NP
39	CHC306T	Tumour	LIVER	ENST00000227758	c.1723A>G	p.M575V	COSMIC	NP	NP
40	H1155	Cell Line	LUNG	ENST00000227758	c.548C>T	p.T183I	COSMIC	NP	NP
41	H650	Cell Line	LUNG	ENST00000227758	c.1026A>T	p.Q342H	COSMIC	NP	NP
42	HCC84T	Tumour	LIVER	ENST00000227758	c.1808C>T	p.P603L	COSMIC	NP	NP
43	ICGC	Tumour	0013 PANCREAS	ENST00000227758	c.1748T>A	p.F583Y	COSMIC	NP	NP
44	K140	Tumour	KIDNEY	ENST00000227758	c.352T>G	p.S118A	COSMIC	NP	NP
45	LUAD-RT-S01702	Tumour	LUNG	ENST00000227758	c.171C>T	p.P57P	COSMIC	NP	NP
46	ME016T	Tumour	SKIN	ENST00000227758	c.17C>T	p.S6F	COSMIC	NP	NP
47	PD4100a	Tumour	BREAST	ENST00000227758	c.91T>A	p.W31R	COSMIC	NP	NP
48	PR-2682	Tumour	PROSTATE	ENST00000227758	c.714A>C	p.S238S	COSMIC	NP	NP
49	TCGA-04-1338-01	Tumour	OVARY	ENST00000227758	c.327C>T	p.S109S	COSMIC	NP	NP
50	TCGA-44-6774-01	Tumour	LUNG	ENST00000227758	c.1225G>T	p.V409L	COSMIC	NP	NP
51	TCGA-85-6561-01	Tumour	LUNG	ENST00000227758	c.992C>A	p.P331Q	COSMIC	NP	NP
52	TCGA-95-7043-01	Tumour	LUNG	ENST00000227758	c.1366+1G>T	p.?	COSMIC	NP	NP
53	TCGA-97-7938-01	Tumour	LUNG	ENST00000227758	c.744A>G	p.P248P	COSMIC	NP	NP
54	TCGA-A5-A0GW-01	Tumour	ENDOMETRIUM	ENST00000227758	c.892G>A	p.V298M	COSMIC	NP	NP
55	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000227758	c.980C>T	p.A327V	COSMIC	NP	NP
56	TCGA-AA-A022-01	Tumour	LARGE INTESTINE	ENST00000227758	c.62T>C	p.I21T	COSMIC	NP	NP
57	TCGA-AG-3601-01	Tumour	LARGE INTESTINE	ENST00000227758	c.1036G>T	p.D346Y	COSMIC	NP	NP
58	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000227758	c.1384C>T	p.R462W	COSMIC	NP	NP
59	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000227758	c.533G>T	p.S178I	COSMIC	NP	NP
60	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1005C>A	p.F335L	COSMIC	NP	NP
61	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1522G>T	p.E508*	COSMIC	NP	NP
62	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1739C>A	p.S580Y	COSMIC	NP	NP
63	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000227758	c.758C>A	p.S253Y	COSMIC	NP	NP
64	TCGA-B0-4712-01	Tumour	KIDNEY	ENST00000227758	c.1013G>T	p.R338L	COSMIC	NP	NP
65	TCGA-B5-A11J-01	Tumour	ENDOMETRIUM	ENST00000227758	c.582G>A	p.W194*	COSMIC	NP	NP
66	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000227758	c.758C>A	p.S253Y	COSMIC	NP	NP
67	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1005C>A	p.F335L	COSMIC	NP	NP
68	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000227758	c.27T>G	p.L9L	COSMIC	NP	NP
69	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1785T>C	p.C595C	COSMIC	NP	NP
70	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000227758	c.542T>C	p.M181T	COSMIC	NP	NP
71	TCGA-BS-A0V8-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1303C>G	p.L435V	COSMIC	NP	NP
72	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000227758	c.454T>C	p.S152P	COSMIC	NP	NP
73	TCGA-CZ-5462-01	Tumour	KIDNEY	ENST00000227758	c.994A>G	p.R332G	COSMIC	NP	NP
74	TCGA-D5-6923-01	Tumour	LARGE INTESTINE	ENST00000227758	c.325A>T	p.S109C	COSMIC	NP	NP
75	TCGA-J4-8198-01	Tumour	PROSTATE	ENST00000227758	c.1501C>G	p.Q501E	COSMIC	NP	NP
76	ccRCC-17	Tumour	KIDNEY	ENST00000227758	c.86C>T	p.S29L	COSMIC	NP	NP
77	ccRCC-53	Tumour	KIDNEY	ENST00000227758	c.709A>G	p.M237V	COSMIC	NP	NP
78	BEN	Cell Line	LUNG	ENST00000227758	c.1082C>G	p.S361*	COSMIC	NP	NP
79	CAR1	Cell Line	LARGE_INTESTINE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
80	CCK81	Cell Line	LARGE_INTESTINE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
81	CORL279	Cell Line	LUNG	ENST00000227758	c.1179A>T	p.T393T	COSMIC	NP	NP
82	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1392C>T	p.N464N	COSMIC	NP	NP
83	EN	Cell Line	ENDOMETRIUM	ENST00000227758	c.1324_1325insA	p.R442fs*10	COSMIC	NP	NP
84	EN	Cell Line	ENDOMETRIUM	ENST00000227758	c.1834A>G	p.T612A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
85	FADU	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000227758	c.1560G>A	p.A520A	COSMIC	NP	NP
86	FU97	Cell Line	STOMACH	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
87	FUOV1	Cell Line	OVARY	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
88	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1602A>G	p.T534T	COSMIC	NP	NP
89	HEMCSS	Cell Line	BONE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
90	HS445	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1559C>T	p.A520V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
91	ISTMEL1	Cell Line	SKIN	ENST00000227758	c.634A>G	p.I212V	COSMIC	PASSENGER/OTHER	BENIGN
92	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.228T>G	p.G76G	COSMIC	NP	NP
93	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
94	KINGS1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
95	KOPN8	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
96	LOUCY	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.417A>G	p.L139L	COSMIC	NP	NP
97	MCIXC	Cell Line	AUTONOMIC_GANGLIA	ENST00000227758	c.970G>T	p.V324L	COSMIC	PASSENGER/OTHER	BENIGN
98	MFHINO	Cell Line	SOFT_TISSUE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
99	MKN7	Cell Line	STOMACH	ENST00000227758	c.55delA	p.K19fs*3	COSMIC	NP	NP
100	MOLM16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1730A>G	p.K577R	COSMIC	PASSENGER/OTHER	BENIGN
101	MRKNU1	Cell Line	BREAST	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
102	MYM12	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
103	NCIH1105	Cell Line	LUNG	ENST00000227758	c.1013G>A	p.R338Q	COSMIC	PASSENGER/OTHER	BENIGN
104	NCIH1155	Cell Line	LUNG	ENST00000227758	c.548C>T	p.T183I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
105	NCIH650	Cell Line	LUNG	ENST00000227758	c.1026A>T	p.Q342H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
106	OCUBM	Cell Line	BREAST	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
107	P12ICHIKAWA	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
108	P30OHK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
109	QGP1	Cell Line	PANCREAS	ENST00000227758	c.1416G>T	p.L472F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
110	SC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1074+9A>G	p.?	COSMIC	NP	NP
111	SN12C	Cell Line	KIDNEY	ENST00000227758	c.1196C>T	p.A399V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
112	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000227758	c.507C>A	p.I169I	COSMIC	NP	NP
113	SNU81	Cell Line	LARGE_INTESTINE	ENST00000227758	c.1588G>T	p.E530*	COSMIC	NP	NP
114	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000227758	c.430G>C	p.E144Q	COSMIC	PASSENGER/OTHER	BENIGN
115	TGBC1TKB	Cell Line	BILIARY_TRACT	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
116	TT	Cell Line	OESOPHAGUS	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
117	BEN	Cell Line	LUNG	NP_001157	c.1082C>G	p.S361*	CCLE	NP	NP
118	EN	Cell Line	ENDOMETRIUM	NP_001157	c.1318_1319insA	p.E440fs	CCLE	NP	NP
119	EN	Cell Line	ENDOMETRIUM	NP_001157	c.1834A>G	p.T612A	CCLE	PASSENGER/OTHER	Possibly Damaging
120	HEC251	Cell Line	ENDOMETRIUM	NP_001157	c.252C>A	p.F84L	CCLE	PASSENGER/OTHER	Possibly Damaging
121	HEC50B	Cell Line	ENDOMETRIUM	NP_001157	c.592T>G	p.F198V	CCLE	PASSENGER/OTHER	Benign
122	HEC6	Cell Line	ENDOMETRIUM	NP_001157	c.1181C>T	p.P394L	CCLE	PASSENGER/OTHER	Possibly Damaging
123	HEC6	Cell Line	ENDOMETRIUM	NP_001157	c.322C>G	p.P108A	CCLE	PASSENGER/OTHER	Probably Damaging
124	HUG1N	Cell Line	STOMACH	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
125	IM95	Cell Line	STOMACH	NP_001157	c.1012C>T	p.R338*	CCLE	NP	NP
126	JHUEM7	Cell Line	ENDOMETRIUM	NP_001157	c.1702G>T	p.E568*	CCLE	NP	NP
127	KALS1	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
128	KASUMI6	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
129	KNS42	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
130	KURAMOCHI	Cell Line	OVARY	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
131	LU65	Cell Line	LUNG	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
132	MKN7	Cell Line	STOMACH	NP_001157	c.55_55delA	p.K19fs	CCLE	NP	NP
133	NCCSTCK140	Cell Line	STOMACH	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
134	NCIH1105	Cell Line	LUNG	NP_001157	c.1013G>A	p.R338Q	CCLE	PASSENGER/OTHER	Benign
135	NCIH2141	Cell Line	LUNG	NP_001157	c.638G>T	p.G213V	CCLE	PASSENGER/OTHER	Probably Damaging
136	NCIH650	Cell Line	LUNG	NP_001157	c.1026A>T	p.Q342H	CCLE	PASSENGER/OTHER	Possibly Damaging
137	QGP1	Cell Line	PANCREAS	NP_001157	c.1416G>T	p.L472F	CCLE	PASSENGER/OTHER	Probably Damaging
138	SKNMC	Cell Line	BONE	NP_001157	c.970G>T	p.V324L	CCLE	PASSENGER/OTHER	Benign
139	SNU1040	Cell Line	LARGE INTESTINE	NP_001157	c.1318_1319insA	p.E440fs	CCLE	NP	NP
140	SNU1197	Cell Line	LARGE INTESTINE	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
141	SNU466	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001157	c.454T>G	p.S152A	CCLE	PASSENGER/OTHER	Benign
142	SNU81	Cell Line	LARGE INTESTINE	NP_001157	c.1588G>T	p.E530*	CCLE	NP	NP
143	SNUC2A	Cell Line	LARGE INTESTINE	NP_001157	c.430G>C	p.E144Q	CCLE	PASSENGER/OTHER	Benign
144	018	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000227758	c.946T>C	p.W316R	COSMIC	NP	NP
145	018-0046-01TD	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000227758	c.946T>C	p.W316R	COSMIC	NP	NP
146	107529	Tumour	BREAST	ENST00000227758	c.605C>G	p.S202*	COSMIC	NP	NP
147	112313	Tumour	LUNG	ENST00000227758	c.956G>A	p.G319E	COSMIC	NP	NP
148	134427	Tumour	LUNG	ENST00000227758	c.555A>T	p.E185D	COSMIC	NP	NP
149	1604875	Tumour	UPPER AERODIGESTIVE TRACT	ENST00000227758	c.1468A>G	p.K490E	COSMIC	NP	NP
150	2334196	Cell Line	LUNG	ENST00000227758	c.638G>T	p.G213V	COSMIC	NP	NP
151	587222	Tumour	LARGE INTESTINE	ENST00000227758	c.235G>T	p.D79Y	COSMIC	NP	NP
152	587376	Tumour	LARGE INTESTINE	ENST00000227758	c.1266G>T	p.E422D	COSMIC	NP	NP
153	587376	Tumour	LARGE INTESTINE	ENST00000227758	c.1734A>C	p.E578D	COSMIC	NP	NP
154	8012788	Tumour	PANCREAS	ENST00000227758	c.1748T>A	p.F583Y	COSMIC	NP	NP
155	CHC306T	Tumour	LIVER	ENST00000227758	c.1723A>G	p.M575V	COSMIC	NP	NP
156	H1155	Cell Line	LUNG	ENST00000227758	c.548C>T	p.T183I	COSMIC	NP	NP
157	H650	Cell Line	LUNG	ENST00000227758	c.1026A>T	p.Q342H	COSMIC	NP	NP
158	HCC84T	Tumour	LIVER	ENST00000227758	c.1808C>T	p.P603L	COSMIC	NP	NP
159	ICGC	Tumour	0013 PANCREAS	ENST00000227758	c.1748T>A	p.F583Y	COSMIC	NP	NP
160	K140	Tumour	KIDNEY	ENST00000227758	c.352T>G	p.S118A	COSMIC	NP	NP
161	LUAD-RT-S01702	Tumour	LUNG	ENST00000227758	c.171C>T	p.P57P	COSMIC	NP	NP
162	ME016T	Tumour	SKIN	ENST00000227758	c.17C>T	p.S6F	COSMIC	NP	NP
163	PD4100a	Tumour	BREAST	ENST00000227758	c.91T>A	p.W31R	COSMIC	NP	NP
164	PR-2682	Tumour	PROSTATE	ENST00000227758	c.714A>C	p.S238S	COSMIC	NP	NP
165	TCGA-04-1338-01	Tumour	OVARY	ENST00000227758	c.327C>T	p.S109S	COSMIC	NP	NP
166	TCGA-44-6774-01	Tumour	LUNG	ENST00000227758	c.1225G>T	p.V409L	COSMIC	NP	NP
167	TCGA-85-6561-01	Tumour	LUNG	ENST00000227758	c.992C>A	p.P331Q	COSMIC	NP	NP
168	TCGA-95-7043-01	Tumour	LUNG	ENST00000227758	c.1366+1G>T	p.?	COSMIC	NP	NP
169	TCGA-97-7938-01	Tumour	LUNG	ENST00000227758	c.744A>G	p.P248P	COSMIC	NP	NP
170	TCGA-A5-A0GW-01	Tumour	ENDOMETRIUM	ENST00000227758	c.892G>A	p.V298M	COSMIC	NP	NP
171	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000227758	c.980C>T	p.A327V	COSMIC	NP	NP
172	TCGA-AA-A022-01	Tumour	LARGE INTESTINE	ENST00000227758	c.62T>C	p.I21T	COSMIC	NP	NP
173	TCGA-AG-3601-01	Tumour	LARGE INTESTINE	ENST00000227758	c.1036G>T	p.D346Y	COSMIC	NP	NP
174	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000227758	c.1384C>T	p.R462W	COSMIC	NP	NP
175	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000227758	c.533G>T	p.S178I	COSMIC	NP	NP
176	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1005C>A	p.F335L	COSMIC	NP	NP
177	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1522G>T	p.E508*	COSMIC	NP	NP
178	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1739C>A	p.S580Y	COSMIC	NP	NP
179	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000227758	c.758C>A	p.S253Y	COSMIC	NP	NP
180	TCGA-B0-4712-01	Tumour	KIDNEY	ENST00000227758	c.1013G>T	p.R338L	COSMIC	NP	NP
181	TCGA-B5-A11J-01	Tumour	ENDOMETRIUM	ENST00000227758	c.582G>A	p.W194*	COSMIC	NP	NP
182	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000227758	c.758C>A	p.S253Y	COSMIC	NP	NP
183	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1005C>A	p.F335L	COSMIC	NP	NP
184	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000227758	c.27T>G	p.L9L	COSMIC	NP	NP
185	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1785T>C	p.C595C	COSMIC	NP	NP
186	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000227758	c.542T>C	p.M181T	COSMIC	NP	NP
187	TCGA-BS-A0V8-01	Tumour	ENDOMETRIUM	ENST00000227758	c.1303C>G	p.L435V	COSMIC	NP	NP
188	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000227758	c.454T>C	p.S152P	COSMIC	NP	NP
189	TCGA-CZ-5462-01	Tumour	KIDNEY	ENST00000227758	c.994A>G	p.R332G	COSMIC	NP	NP
190	TCGA-D5-6923-01	Tumour	LARGE INTESTINE	ENST00000227758	c.325A>T	p.S109C	COSMIC	NP	NP
191	TCGA-J4-8198-01	Tumour	PROSTATE	ENST00000227758	c.1501C>G	p.Q501E	COSMIC	NP	NP
192	ccRCC-17	Tumour	KIDNEY	ENST00000227758	c.86C>T	p.S29L	COSMIC	NP	NP
193	ccRCC-53	Tumour	KIDNEY	ENST00000227758	c.709A>G	p.M237V	COSMIC	NP	NP
194	BEN	Cell Line	LUNG	ENST00000227758	c.1082C>G	p.S361*	COSMIC	NP	NP
195	CAR1	Cell Line	LARGE_INTESTINE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
196	CCK81	Cell Line	LARGE_INTESTINE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
197	CORL279	Cell Line	LUNG	ENST00000227758	c.1179A>T	p.T393T	COSMIC	NP	NP
198	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1392C>T	p.N464N	COSMIC	NP	NP
199	EN	Cell Line	ENDOMETRIUM	ENST00000227758	c.1324_1325insA	p.R442fs*10	COSMIC	NP	NP
200	EN	Cell Line	ENDOMETRIUM	ENST00000227758	c.1834A>G	p.T612A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
201	FADU	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000227758	c.1560G>A	p.A520A	COSMIC	NP	NP
202	FU97	Cell Line	STOMACH	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
203	FUOV1	Cell Line	OVARY	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
204	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1602A>G	p.T534T	COSMIC	NP	NP
205	HEMCSS	Cell Line	BONE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
206	HS445	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1559C>T	p.A520V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
207	ISTMEL1	Cell Line	SKIN	ENST00000227758	c.634A>G	p.I212V	COSMIC	PASSENGER/OTHER	BENIGN
208	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.228T>G	p.G76G	COSMIC	NP	NP
209	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
210	KINGS1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
211	KOPN8	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
212	LOUCY	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.417A>G	p.L139L	COSMIC	NP	NP
213	MCIXC	Cell Line	AUTONOMIC_GANGLIA	ENST00000227758	c.970G>T	p.V324L	COSMIC	PASSENGER/OTHER	BENIGN
214	MFHINO	Cell Line	SOFT_TISSUE	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
215	MKN7	Cell Line	STOMACH	ENST00000227758	c.55delA	p.K19fs*3	COSMIC	NP	NP
216	MOLM16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1730A>G	p.K577R	COSMIC	PASSENGER/OTHER	BENIGN
217	MRKNU1	Cell Line	BREAST	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
218	MYM12	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
219	NCIH1105	Cell Line	LUNG	ENST00000227758	c.1013G>A	p.R338Q	COSMIC	PASSENGER/OTHER	BENIGN
220	NCIH1155	Cell Line	LUNG	ENST00000227758	c.548C>T	p.T183I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
221	NCIH650	Cell Line	LUNG	ENST00000227758	c.1026A>T	p.Q342H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
222	OCUBM	Cell Line	BREAST	ENST00000227758	c.495A>G	p.A165A	COSMIC	NP	NP
223	P12ICHIKAWA	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
224	P30OHK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
225	QGP1	Cell Line	PANCREAS	ENST00000227758	c.1416G>T	p.L472F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
226	SC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000227758	c.1074+9A>G	p.?	COSMIC	NP	NP
227	SN12C	Cell Line	KIDNEY	ENST00000227758	c.1196C>T	p.A399V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
228	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000227758	c.507C>A	p.I169I	COSMIC	NP	NP
229	SNU81	Cell Line	LARGE_INTESTINE	ENST00000227758	c.1588G>T	p.E530*	COSMIC	NP	NP
230	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000227758	c.430G>C	p.E144Q	COSMIC	PASSENGER/OTHER	BENIGN
231	TGBC1TKB	Cell Line	BILIARY_TRACT	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP
232	TT	Cell Line	OESOPHAGUS	ENST00000227758	c.1638G>A	p.K546K	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	10.3647	10.457	-0.2415	-0.1185
BILIARY TRACT	10.8687	10.897	0.1386	0.0239
BONE	11.1872	11.276	0.0761	-0.0018
BREAST	10.7227	10.79	-0.0514	-0.0027
CENTRAL NERVOUS SYSTEM	11.2268	11.215	-0.0897	-0.0787
ENDOMETRIUM	11.0304	10.972	0.0044	-0.0087
HAEMATOPOIETIC AND LYMPHOID TISSUE	10.3918	10.47	-0.0558	-0.007687
KIDNEY	11.2796	11.216	-0.1745	-0.1612
LARGE INTESTINE	10.6080	10.5615	0.0800	0.0018
LIVER	10.9640	10.92	-0.0337	0.01136
LUNG	10.8263	10.857	0.1112	0.1252
OESOPHAGUS	10.8640	10.8095	0.3575	0.26395
OVARY	11.1427	11.177	0.2766	0.1634
PANCREAS	11.1492	11.11	0.2905	0.2872
PLEURA	10.9107	11.044	-0.1639	-0.1592
PROSTATE	11.0285	10.744	0.0859	0.04605
SALIVARY GLAND	10.4850	10.485	-0.4050	-0.405
SKIN	10.9396	10.971	-0.2082	-0.1475
SMALL INTESTINE	11.1320	11.132	-0.0067	-0.0067
SOFT TISSUE	11.0248	11.1155	-0.0156	-0.014875
STOMACH	10.8668	10.8175	0.2262	0.1871
THYROID	10.8564	10.866	0.0040	-0.0025
UPPER AERODIGESTIVE TRACT	11.1925	11.0695	0.2260	0.20045
URINARY TRACT	10.9286	10.7885	0.1112	0.0499

Domain ID	Domain Name	Start Site	End Site	E-value
PF00653	BIR	49	114	8.2e-20
PF00653	BIR	187	250	2.2e-21
PF00653	BIR	272	336	2.3e-23
PF00619	CARD	459	540	1.4e-22
PF10217	DUF2039	564	606	0.44
PF13920	zf-C3HC4_3	568	610	1.5e-14
PF00653	BIR	49	114	8.2e-20
PF00653	BIR	187	250	2.2e-21
PF00653	BIR	272	336	2.3e-23
PF00619	CARD	459	540	1.4e-22
PF10217	DUF2039	564	606	0.44
PF13920	zf-C3HC4_3	568	610	1.5e-14

Domain ID	Start Site	End Site	E-value
0036727	263	350	1.83e-44
0036727	176	251	1.30e-31
0036727	39	137	3.01e-30
0045502	453	551	6.59e-23
0036727	263	350	1.83e-44
0036727	176	251	1.30e-31
0036727	39	137	3.01e-30
0045502	453	551	6.59e-23

S. No.	Position	Amino acid	Type	Description
1	126	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	140	S	Phosphorylation	Phosphoserine
3	147	S	Phosphorylation	Phosphoserine
4	157	S	Phosphorylation	Phosphoserine
5	19	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
6	226	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
7	233	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
8	340	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
9	36	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
10	40	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
11	410	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	416	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
13	425	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
14	441	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
15	446	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
16	448	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
17	537	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
18	126	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
19	140	S	Phosphorylation	Phosphoserine
20	147	S	Phosphorylation	Phosphoserine
21	157	S	Phosphorylation	Phosphoserine
22	19	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
23	226	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
24	233	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
25	340	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
26	36	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
27	40	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
28	410	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
29	416	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
30	425	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
31	441	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
32	446	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
33	448	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
34	537	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BIRC2	BIRC2	BIRC2	ENSP00000227758	Q13490
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q13490	BIRC2	ENSP00000227758	BIRC2	Q13490
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BIRC2	ENSP00000227758	601712	Q13490	PA25359

Protein: BIRC2

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7