ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	8505C	Cell Line	THYROID	NP_001188	c.457G>A	p.G153R	CCLE	NP	NP
2	BECKER	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001188	c.199G>A	p.E67K	CCLE	NP	NP
3	CAL33	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001188	c.458G>A	p.G153E	CCLE	NP	NP
4	KMS27	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001188	c.443_444insGCC	p.149_150insP	CCLE	NP	NP
5	KYSE450	Cell Line	OESOPHAGUS	NP_001188	c.457G>A	p.G153R	CCLE	NP	NP
6	NCIH2110	Cell Line	LUNG	NP_001188	c.434_445delCGCTGCTGCTGC	p.LLLP146del	CCLE	NP	NP
7	RCHACV	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001188	c.417_425delGCTGCTGCT	p.LLL140del	CCLE	NP	NP
8	ESO-153	Tumour	OESOPHAGUS	ENST00000216115	c.111_116delGGACCT	p.L39_D40delLD	COSMIC	NP	NP
9	ESO-859	Tumour	OESOPHAGUS	ENST00000216115	c.445C>G	p.P149A	COSMIC	NP	NP
10	PD4937a	Tumour	BREAST	ENST00000216115	c.28G>C	p.D10H	COSMIC	NP	NP
11	TCGA-29-1771-01	Tumour	OVARY	ENST00000216115	c.46C>T	p.L16F	COSMIC	NP	NP
12	TCGA-A5-A0VP-01	Tumour	ENDOMETRIUM	ENST00000216115	c.381C>T	p.P127P	COSMIC	NP	NP
13	TCGA-AA-3819-01	Tumour	LARGE INTESTINE	ENST00000216115	c.426_427GC>AA	p.L142>?	COSMIC	NP	NP
14	TCGA-AX-A0IS-01	Tumour	ENDOMETRIUM	ENST00000216115	c.94A>C	p.M32L	COSMIC	NP	NP
15	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000216115	c.283G>A	p.D95N	COSMIC	NP	NP
16	TCGA-BT-A20T-01	Tumour	URINARY TRACT	ENST00000216115	c.135C>T	p.F45F	COSMIC	NP	NP
17	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000216115	c.400G>A	p.E134K	COSMIC	NP	NP
18	TCGA-EW-A1OY-01	Tumour	BREAST	ENST00000216115	c.407_424del18	p.L143_L148delLLALLL	COSMIC	NP	NP
19	CAL33	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000216115	c.458G>A	p.G153E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
20	ES6	Cell Line	BONE	ENST00000216115	c.459G>A	p.G153G	COSMIC	NP	NP
21	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000216115	c.74_75insC	p.T26fs*9	COSMIC	NP	NP
22	RCHACV	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000216115	c.417_425delGCTGCTGCT	p.L142	COSMIC	NP	NP
23	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000216115	c.382G>A	p.G128R	COSMIC	PASSENGER/OTHER	BENIGN
24	8505C	Cell Line	THYROID	NP_001188	c.457G>A	p.G153R	CCLE	NP	NP
25	BECKER	Cell Line	CENTRAL NERVOUS SYSTEM	NP_001188	c.199G>A	p.E67K	CCLE	NP	NP
26	CAL33	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001188	c.458G>A	p.G153E	CCLE	NP	NP
27	KMS27	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001188	c.443_444insGCC	p.149_150insP	CCLE	NP	NP
28	KYSE450	Cell Line	OESOPHAGUS	NP_001188	c.457G>A	p.G153R	CCLE	NP	NP
29	NCIH2110	Cell Line	LUNG	NP_001188	c.434_445delCGCTGCTGCTGC	p.LLLP146del	CCLE	NP	NP
30	RCHACV	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001188	c.417_425delGCTGCTGCT	p.LLL140del	CCLE	NP	NP
31	ESO-153	Tumour	OESOPHAGUS	ENST00000216115	c.111_116delGGACCT	p.L39_D40delLD	COSMIC	NP	NP
32	ESO-859	Tumour	OESOPHAGUS	ENST00000216115	c.445C>G	p.P149A	COSMIC	NP	NP
33	PD4937a	Tumour	BREAST	ENST00000216115	c.28G>C	p.D10H	COSMIC	NP	NP
34	TCGA-29-1771-01	Tumour	OVARY	ENST00000216115	c.46C>T	p.L16F	COSMIC	NP	NP
35	TCGA-A5-A0VP-01	Tumour	ENDOMETRIUM	ENST00000216115	c.381C>T	p.P127P	COSMIC	NP	NP
36	TCGA-AA-3819-01	Tumour	LARGE INTESTINE	ENST00000216115	c.426_427GC>AA	p.L142>?	COSMIC	NP	NP
37	TCGA-AX-A0IS-01	Tumour	ENDOMETRIUM	ENST00000216115	c.94A>C	p.M32L	COSMIC	NP	NP
38	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000216115	c.283G>A	p.D95N	COSMIC	NP	NP
39	TCGA-BT-A20T-01	Tumour	URINARY TRACT	ENST00000216115	c.135C>T	p.F45F	COSMIC	NP	NP
40	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000216115	c.400G>A	p.E134K	COSMIC	NP	NP
41	TCGA-EW-A1OY-01	Tumour	BREAST	ENST00000216115	c.407_424del18	p.L143_L148delLLALLL	COSMIC	NP	NP
42	CAL33	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000216115	c.458G>A	p.G153E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
43	ES6	Cell Line	BONE	ENST00000216115	c.459G>A	p.G153G	COSMIC	NP	NP
44	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000216115	c.74_75insC	p.T26fs*9	COSMIC	NP	NP
45	RCHACV	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000216115	c.417_425delGCTGCTGCT	p.L142	COSMIC	NP	NP
46	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000216115	c.382G>A	p.G128R	COSMIC	PASSENGER/OTHER	BENIGN

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.1424	4.9529	-0.1042	0.02192
BILIARY TRACT	9.0991	10.127	-0.1246	-0.3097
BONE	5.3951	5.456	-0.0534	-0.02018
BREAST	7.8872	8.0772	-0.1689	-0.1727
CENTRAL NERVOUS SYSTEM	5.6511	5.7135	-0.2537	-0.1704
ENDOMETRIUM	7.7409	7.674	-0.1312	-0.05693
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.3888	7.0479	-0.0851	-0.0133
KIDNEY	6.6276	6.3615	-0.0058	0.0559
LARGE INTESTINE	9.5941	10.238	-0.2292	-0.09115
LIVER	6.3498	6.1539	-0.0723	-0.163
LUNG	7.5995	7.50195	-0.2492	-0.23735
OESOPHAGUS	8.5301	8.39375	-0.2145	-0.2369
OVARY	7.9650	8.0219	-0.2136	-0.1865
PANCREAS	9.5661	10.112	-0.2270	-0.2383
PLEURA	6.8575	6.3057	-0.3143	-0.1773
PROSTATE	8.3717	8.38585	-0.2564	-0.2091
SALIVARY GLAND	9.6087	9.6087	0.1642	0.1642
SKIN	6.3662	6.1996	0.1569	0.2052
SMALL INTESTINE	5.6135	5.6135	0.0254	0.02535
SOFT TISSUE	5.3420	5.34405	-0.1417	-0.029013
STOMACH	8.5035	9.2527	-0.1702	-0.1419
THYROID	6.4802	6.26655	-0.1219	-0.059545
UPPER AERODIGESTIVE TRACT	9.0381	9.1645	0.0296	0.0097
URINARY TRACT	8.3224	8.36625	-0.1114	-0.046155

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	2IPE

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF12201	bcl-2I13	1	159	1e-93
PF00517	GP41	93	147	0.062
PF12201	bcl-2I13	1	159	1e-93
PF00517	GP41	93	147	0.062

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

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2. Sequence alignment with CCLE mutants:

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3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

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Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	115	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	33	T	Phosphorylation	Phosphothreonine
3	35	S	Phosphorylation	Phosphoserine
4	35	S	Phosphorylation	Phosphoserine (CK2_alpha)
5	115	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
6	33	T	Phosphorylation	Phosphothreonine
7	35	S	Phosphorylation	Phosphoserine
8	35	S	Phosphorylation	Phosphoserine (CK2_alpha)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BIK	BIK	BIK	ENSP00000216115	Q13323
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q13323	BIK	ENSP00000216115	BIK	Q13323
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BIK	ENSP00000216115	603392	Q13323	PA25354

Protein: BIK

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)