ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	IGROV1	Cell Line	OVARY	NP_932070	c.451C>A	p.L151M	CCLE	PASSENGER/OTHER	Benign
2	KE97	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_932070	c.501_splice	p.E167_splice	CCLE	NP	NP
3	MFE319	Cell Line	ENDOMETRIUM	NP_932070	c.47_47delG	p.G16fs	CCLE	NP	NP
4	NCIH2106	Cell Line	LUNG	NP_932070	c.694G>T	p.V232L	CCLE	NP	NP
5	PANC0327	Cell Line	PANCREAS	NP_932070	c.362_splice	p.D121_splice	CCLE	NP	NP
6	TCGA-24-1423-01	Tumour	OVARY	ENST00000317361	c.329G>C	p.S110T	COSMIC	NP	NP
7	TCGA-A6-2676-01	Tumour	LARGE INTESTINE	ENST00000317361	c.421G>A	p.D141N	COSMIC	NP	NP
8	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000317361	c.648C>A	p.V216V	COSMIC	NP	NP
9	IGROV1	Cell Line	OVARY	NP_932070	c.451C>A	p.L151M	CCLE	PASSENGER/OTHER	Benign
10	KE97	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_932070	c.501_splice	p.E167_splice	CCLE	NP	NP
11	MFE319	Cell Line	ENDOMETRIUM	NP_932070	c.47_47delG	p.G16fs	CCLE	NP	NP
12	NCIH2106	Cell Line	LUNG	NP_932070	c.694G>T	p.V232L	CCLE	NP	NP
13	PANC0327	Cell Line	PANCREAS	NP_932070	c.362_splice	p.D121_splice	CCLE	NP	NP
14	TCGA-24-1423-01	Tumour	OVARY	ENST00000317361	c.329G>C	p.S110T	COSMIC	NP	NP
15	TCGA-A6-2676-01	Tumour	LARGE INTESTINE	ENST00000317361	c.421G>A	p.D141N	COSMIC	NP	NP
16	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000317361	c.648C>A	p.V216V	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for BID!!

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1ZY3, 2BID, 2KBW, 2M5B, 2M5I, 4BD2

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF06393	BID	1	195	5e-94
PF13012	MitMem_reg	55	174	0.17
PF06393	BID	1	195	5e-94
PF13012	MitMem_reg	55	174	0.17

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0045190	1	194	3.12e-78
0045190	1	194	3.12e-78

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

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4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	158	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	54	Y	Phosphorylation	Phosphotyrosine
3	54	Y	Phosphorylation	Phosphotyrosine.
4	54	Y	Proteolytic Cleavage	none
5	59	T	Phosphorylation	Phosphothreonine (CK1_group;CK2_group)
6	59	T	Phosphorylation (CSNK1A1)	Phosphothreonine
7	59	T	Phosphorylation (CSNK1E)	Phosphothreonine
8	59	T	Phosphorylation (CSNK2A1)	Phosphothreonine
9	59	T	Phosphorylation (CSNK2A2)	Phosphothreonine
10	59	T	Phosphorylation (CSNK2B)	Phosphothreonine
11	60	D	Proteolytic Cleavage	none
12	64	S	Phosphorylation	Phosphoserine (CK1_group;CK2_group)
13	64	S	Phosphorylation (CSNK1A1)	Phosphoserine
14	64	S	Phosphorylation (CSNK1E)	Phosphoserine
15	64	S	Phosphorylation (CSNK2A1)	Phosphoserine
16	64	S	Phosphorylation (CSNK2A2)	Phosphoserine
17	64	S	Phosphorylation (CSNK2B)	Phosphoserine
18	75	D	Proteolytic Cleavage	none
19	78	S	Phosphorylation	Phosphoserine
20	78	S	Phosphorylation	Phosphoserine.
21	158	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
22	54	Y	Phosphorylation	Phosphotyrosine
23	54	Y	Phosphorylation	Phosphotyrosine.
24	54	Y	Proteolytic Cleavage	none
25	59	T	Phosphorylation	Phosphothreonine (CK1_group;CK2_group)
26	59	T	Phosphorylation (CSNK1A1)	Phosphothreonine
27	59	T	Phosphorylation (CSNK1E)	Phosphothreonine
28	59	T	Phosphorylation (CSNK2A1)	Phosphothreonine
29	59	T	Phosphorylation (CSNK2A2)	Phosphothreonine
30	59	T	Phosphorylation (CSNK2B)	Phosphothreonine
31	60	D	Proteolytic Cleavage	none
32	64	S	Phosphorylation	Phosphoserine (CK1_group;CK2_group)
33	64	S	Phosphorylation (CSNK1A1)	Phosphoserine
34	64	S	Phosphorylation (CSNK1E)	Phosphoserine
35	64	S	Phosphorylation (CSNK2A1)	Phosphoserine
36	64	S	Phosphorylation (CSNK2A2)	Phosphoserine
37	64	S	Phosphorylation (CSNK2B)	Phosphoserine
38	75	D	Proteolytic Cleavage	none
39	78	S	Phosphorylation	Phosphoserine
40	78	S	Phosphorylation	Phosphoserine.

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BID	BID	BID	ENSP00000318822	P55957
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P55957	BID	ENSP00000318822	BID	P55957
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BID	ENSP00000318822	601997	P55957	PA25353

Protein: BID

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)