ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	585205	Tumour	LUNG	ENST00000361523	c.1133A>G	p.Q378R	COSMIC	NP	NP
2	ESO-717	Tumour	OESOPHAGUS	ENST00000361523	c.365T>C	p.L122P	COSMIC	NP	NP
3	HCC2998	Cell Line	LARGE INTESTINE	ENST00000361523	c.1324T>C	p.W442R	COSMIC	NP	NP
4	HCC51T	Tumour	LIVER	ENST00000361523	c.375_377delCAT	p.I125delI	COSMIC	NP	NP
5	ME050T	Tumour	SKIN	ENST00000361523	c.199G>A	p.E67K	COSMIC	NP	NP
6	PA285	Cell Line	PANCREAS	ENST00000361523	c.558G>A	p.E186E	COSMIC	NP	NP
7	RK126	Tumour	C01 LIVER	ENST00000361523	c.1042-3C>G	p.?	COSMIC	NP	NP
8	TCGA-05-4249-01	Tumour	LUNG	ENST00000361523	c.918T>C	p.A306A	COSMIC	NP	NP
9	TCGA-18-3419-01	Tumour	LUNG	ENST00000361523	c.927G>C	p.Q309H	COSMIC	NP	NP
10	TCGA-24-1464-01	Tumour	OVARY	ENST00000361523	c.1214A>G	p.D405G	COSMIC	NP	NP
11	TCGA-64-5774-01	Tumour	LUNG	ENST00000361523	c.1313G>T	p.W438L	COSMIC	NP	NP
12	TCGA-85-6561-01	Tumour	LUNG	ENST00000361523	c.1120G>T	p.D374Y	COSMIC	NP	NP
13	TCGA-A3-3372-01	Tumour	KIDNEY	ENST00000361523	c.494G>T	p.C165F	COSMIC	NP	NP
14	TCGA-AA-3848-01	Tumour	LARGE INTESTINE	ENST00000361523	c.38A>G	p.Q13R	COSMIC	NP	NP
15	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000361523	c.1000G>A	p.G334R	COSMIC	NP	NP
16	TCGA-AA-3949-01	Tumour	LARGE INTESTINE	ENST00000361523	c.459C>T	p.N153N	COSMIC	NP	NP
17	TCGA-AB-2963-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000361523	c.542A>G	p.Q181R	COSMIC	NP	NP
18	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000361523	c.694G>T	p.E232*	COSMIC	NP	NP
19	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000361523	c.405A>G	p.P135P	COSMIC	NP	NP
20	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000361523	c.804C>T	p.N268N	COSMIC	NP	NP
21	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000361523	c.1159G>A	p.E387K	COSMIC	NP	NP
22	TCGA-DK-A2HX-01	Tumour	URINARY TRACT	ENST00000361523	c.238C>T	p.R80C	COSMIC	NP	NP
23	TCGA-GC-A3I6-01	Tumour	URINARY TRACT	ENST00000361523	c.1092G>C	p.K364N	COSMIC	NP	NP
24	2313287	Cell Line	STOMACH	ENST00000361523	c.894G>T	p.V298V	COSMIC	NP	NP
25	A427	Cell Line	LUNG	ENST00000361523	c.733G>T	p.D245Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
26	CAL27	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000361523	c.93C>G	p.F31L	COSMIC	PASSENGER/OTHER	BENIGN
27	CROAP2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.318C>T	p.G106G	COSMIC	NP	NP
28	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.1182C>T	p.Y394Y	COSMIC	NP	NP
29	D245MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361523	c.334delC	p.L112fs*5	COSMIC	NP	NP
30	GP5D	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1286T>C	p.L429P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
31	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1324T>C	p.W442R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
32	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000361523	c.609G>A	p.K203K	COSMIC	NP	NP
33	HT55	Cell Line	LARGE_INTESTINE	ENST00000361523	c.199G>A	p.E67K	COSMIC	PASSENGER/OTHER	BENIGN
34	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.879G>A	p.L293L	COSMIC	NP	NP
35	KINGS1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361523	c.980+3A>G	p.?	COSMIC	NP	NP
36	KMH2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.1026G>C	p.L342L	COSMIC	NP	NP
37	MDST8	Cell Line	LARGE_INTESTINE	ENST00000361523	c.327G>T	p.M109I	COSMIC	PASSENGER/OTHER	BENIGN
38	NCIH1304	Cell Line	LUNG	ENST00000361523	c.360G>A	p.G120G	COSMIC	NP	NP
39	NCIH1304	Cell Line	LUNG	ENST00000361523	c.785A>T	p.D262V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	NCIH2081	Cell Line	LUNG	ENST00000361523	c.1105A>G	p.M369V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
41	RCM1	Cell Line	LARGE_INTESTINE	ENST00000361523	c.29G>A	p.S10N	COSMIC	PASSENGER/OTHER	BENIGN
42	RKO	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1302G>A	p.T434T	COSMIC	NP	NP
43	SARC9371	Cell Line	BONE	ENST00000361523	c.978G>A	p.Q326Q	COSMIC	NP	NP
44	SCABER	Cell Line	URINARY_TRACT	ENST00000361523	c.202C>T	p.P68S	COSMIC	PASSENGER/OTHER	BENIGN
45	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1062_1063insG	p.L357fs*10	COSMIC	NP	NP
46	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1261T>A	p.S421T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
47	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000361523	c.254delC	p.P85fs*4	COSMIC	NP	NP
48	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000361523	c.37C>T	p.Q13*	COSMIC	NP	NP
49	TE10	Cell Line	OESOPHAGUS	ENST00000361523	c.260+1G>A	p.?	COSMIC	NP	NP
50	U2OS	Cell Line	BONE	ENST00000361523	c.351+8G>T	p.?	COSMIC	NP	NP
51	585205	Tumour	LUNG	ENST00000361523	c.1133A>G	p.Q378R	COSMIC	NP	NP
52	ESO-717	Tumour	OESOPHAGUS	ENST00000361523	c.365T>C	p.L122P	COSMIC	NP	NP
53	HCC2998	Cell Line	LARGE INTESTINE	ENST00000361523	c.1324T>C	p.W442R	COSMIC	NP	NP
54	HCC51T	Tumour	LIVER	ENST00000361523	c.375_377delCAT	p.I125delI	COSMIC	NP	NP
55	ME050T	Tumour	SKIN	ENST00000361523	c.199G>A	p.E67K	COSMIC	NP	NP
56	PA285	Cell Line	PANCREAS	ENST00000361523	c.558G>A	p.E186E	COSMIC	NP	NP
57	RK126	Tumour	C01 LIVER	ENST00000361523	c.1042-3C>G	p.?	COSMIC	NP	NP
58	TCGA-05-4249-01	Tumour	LUNG	ENST00000361523	c.918T>C	p.A306A	COSMIC	NP	NP
59	TCGA-18-3419-01	Tumour	LUNG	ENST00000361523	c.927G>C	p.Q309H	COSMIC	NP	NP
60	TCGA-24-1464-01	Tumour	OVARY	ENST00000361523	c.1214A>G	p.D405G	COSMIC	NP	NP
61	TCGA-64-5774-01	Tumour	LUNG	ENST00000361523	c.1313G>T	p.W438L	COSMIC	NP	NP
62	TCGA-85-6561-01	Tumour	LUNG	ENST00000361523	c.1120G>T	p.D374Y	COSMIC	NP	NP
63	TCGA-A3-3372-01	Tumour	KIDNEY	ENST00000361523	c.494G>T	p.C165F	COSMIC	NP	NP
64	TCGA-AA-3848-01	Tumour	LARGE INTESTINE	ENST00000361523	c.38A>G	p.Q13R	COSMIC	NP	NP
65	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000361523	c.1000G>A	p.G334R	COSMIC	NP	NP
66	TCGA-AA-3949-01	Tumour	LARGE INTESTINE	ENST00000361523	c.459C>T	p.N153N	COSMIC	NP	NP
67	TCGA-AB-2963-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000361523	c.542A>G	p.Q181R	COSMIC	NP	NP
68	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000361523	c.694G>T	p.E232*	COSMIC	NP	NP
69	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000361523	c.405A>G	p.P135P	COSMIC	NP	NP
70	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000361523	c.804C>T	p.N268N	COSMIC	NP	NP
71	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000361523	c.1159G>A	p.E387K	COSMIC	NP	NP
72	TCGA-DK-A2HX-01	Tumour	URINARY TRACT	ENST00000361523	c.238C>T	p.R80C	COSMIC	NP	NP
73	TCGA-GC-A3I6-01	Tumour	URINARY TRACT	ENST00000361523	c.1092G>C	p.K364N	COSMIC	NP	NP
74	2313287	Cell Line	STOMACH	ENST00000361523	c.894G>T	p.V298V	COSMIC	NP	NP
75	A427	Cell Line	LUNG	ENST00000361523	c.733G>T	p.D245Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
76	CAL27	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000361523	c.93C>G	p.F31L	COSMIC	PASSENGER/OTHER	BENIGN
77	CROAP2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.318C>T	p.G106G	COSMIC	NP	NP
78	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.1182C>T	p.Y394Y	COSMIC	NP	NP
79	D245MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361523	c.334delC	p.L112fs*5	COSMIC	NP	NP
80	GP5D	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1286T>C	p.L429P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
81	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1324T>C	p.W442R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
82	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000361523	c.609G>A	p.K203K	COSMIC	NP	NP
83	HT55	Cell Line	LARGE_INTESTINE	ENST00000361523	c.199G>A	p.E67K	COSMIC	PASSENGER/OTHER	BENIGN
84	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.879G>A	p.L293L	COSMIC	NP	NP
85	KINGS1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361523	c.980+3A>G	p.?	COSMIC	NP	NP
86	KMH2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361523	c.1026G>C	p.L342L	COSMIC	NP	NP
87	MDST8	Cell Line	LARGE_INTESTINE	ENST00000361523	c.327G>T	p.M109I	COSMIC	PASSENGER/OTHER	BENIGN
88	NCIH1304	Cell Line	LUNG	ENST00000361523	c.360G>A	p.G120G	COSMIC	NP	NP
89	NCIH1304	Cell Line	LUNG	ENST00000361523	c.785A>T	p.D262V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
90	NCIH2081	Cell Line	LUNG	ENST00000361523	c.1105A>G	p.M369V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
91	RCM1	Cell Line	LARGE_INTESTINE	ENST00000361523	c.29G>A	p.S10N	COSMIC	PASSENGER/OTHER	BENIGN
92	RKO	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1302G>A	p.T434T	COSMIC	NP	NP
93	SARC9371	Cell Line	BONE	ENST00000361523	c.978G>A	p.Q326Q	COSMIC	NP	NP
94	SCABER	Cell Line	URINARY_TRACT	ENST00000361523	c.202C>T	p.P68S	COSMIC	PASSENGER/OTHER	BENIGN
95	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1062_1063insG	p.L357fs*10	COSMIC	NP	NP
96	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000361523	c.1261T>A	p.S421T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
97	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000361523	c.254delC	p.P85fs*4	COSMIC	NP	NP
98	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000361523	c.37C>T	p.Q13*	COSMIC	NP	NP
99	TE10	Cell Line	OESOPHAGUS	ENST00000361523	c.260+1G>A	p.?	COSMIC	NP	NP
100	U2OS	Cell Line	BONE	ENST00000361523	c.351+8G>T	p.?	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	9.0564	9.0035	0.2193	0.0829
BILIARY TRACT	9.6869	9.7969	0.2171	0.1181
BONE	9.2833	9.3259	-0.1298	-0.01932
BREAST	9.3428	9.3551	-0.2301	-0.1378
CENTRAL NERVOUS SYSTEM	9.4667	9.505	0.0478	0.1076
ENDOMETRIUM	9.4995	9.5105	0.0777	0.0405
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.6487	9.6049	0.0590	0.0237
KIDNEY	9.6004	9.6467	0.1467	0.149
LARGE INTESTINE	9.6496	9.6948	0.0353	0.015805
LIVER	9.4226	9.4266	0.0884	0.1055
LUNG	9.4645	9.4777	0.1196	0.12285
OESOPHAGUS	9.6735	9.78375	0.1061	0.0796
OVARY	9.3556	9.3058	0.0106	0.0149
PANCREAS	9.5858	9.5567	0.1327	0.1627
PLEURA	9.6978	9.6192	0.1699	0.1978
PROSTATE	9.4029	9.55925	-0.0392	0.00373
SALIVARY GLAND	9.5574	9.5574	0.0818	0.0818
SKIN	10.0288	10.043	0.0766	0.0491
SMALL INTESTINE	8.9820	8.982	0.0814	0.08142
SOFT TISSUE	9.3834	9.47615	-0.0530	0.01685
STOMACH	9.6097	9.54295	0.1061	0.03405
THYROID	9.7360	9.74735	0.0559	0.0107
UPPER AERODIGESTIVE TRACT	9.5219	9.53645	0.0002	0.0259
URINARY TRACT	9.4142	9.4842	0.0138	-0.0264

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	2P1L, 2PON, 3DVU, 4DDP, 4MI8

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF15285	BH3	105	129	3.1e-17
PF04111	APG6	135	449	9.7e-130
PF12317	IFT46_B_C	173	262	0.3
PF12777	MT	185	270	0.02
PF04048	Sec8_exocyst	195	253	0.34
PF15285	BH3	105	129	3.1e-17
PF04111	APG6	135	449	9.7e-130
PF12317	IFT46_B_C	173	262	0.3
PF12777	MT	185	270	0.02
PF04048	Sec8_exocyst	195	253	0.34

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0047790	175	280	5.10e-04
0047790	175	280	5.10e-04

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	117	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	119	T	Phosphorylation	Phosphothreonine
3	119	T	Phosphorylation	Phosphothreonine (DAPK1)
4	119	T	Phosphorylation	Phosphothreonine; by DAPK1.
5	206	K	Acetylation	N6-acetyllysine
6	29	T	Phosphorylation	Phosphothreonine.
7	30	S	Phosphorylation	Phosphoserine
8	30	S	Phosphorylation	Phosphoserine.
9	32	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
10	38	T	Phosphorylation	Phosphothreonine
11	402	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	57	T	Phosphorylation	Phosphothreonine
13	57	T	Phosphorylation	Phosphothreonine.
14	62	T	Phosphorylation	Phosphothreonine
15	62	T	Phosphorylation	Phosphothreonine.
16	64	S	Phosphorylation	Phosphoserine
17	64	S	Phosphorylation	Phosphoserine.
18	90	S	Phosphorylation	Phosphoserine
19	90	S	Phosphorylation	Phosphoserine.
20	91	T	Phosphorylation	Phosphothreonine
21	93	S	Phosphorylation	Phosphoserine
22	93	S	Phosphorylation	Phosphoserine.
23	96	S	Phosphorylation	Phosphoserine
24	96	S	Phosphorylation	Phosphoserine.
25	117	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
26	119	T	Phosphorylation	Phosphothreonine
27	119	T	Phosphorylation	Phosphothreonine (DAPK1)
28	119	T	Phosphorylation	Phosphothreonine; by DAPK1.
29	206	K	Acetylation	N6-acetyllysine
30	29	T	Phosphorylation	Phosphothreonine.
31	30	S	Phosphorylation	Phosphoserine
32	30	S	Phosphorylation	Phosphoserine.
33	32	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
34	38	T	Phosphorylation	Phosphothreonine
35	402	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
36	57	T	Phosphorylation	Phosphothreonine
37	57	T	Phosphorylation	Phosphothreonine.
38	62	T	Phosphorylation	Phosphothreonine
39	62	T	Phosphorylation	Phosphothreonine.
40	64	S	Phosphorylation	Phosphoserine
41	64	S	Phosphorylation	Phosphoserine.
42	90	S	Phosphorylation	Phosphoserine
43	90	S	Phosphorylation	Phosphoserine.
44	91	T	Phosphorylation	Phosphothreonine
45	93	S	Phosphorylation	Phosphoserine
46	93	S	Phosphorylation	Phosphoserine.
47	96	S	Phosphorylation	Phosphoserine
48	96	S	Phosphorylation	Phosphoserine.

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BECN1	BECN1	BECN1	ENSP00000355231	Q14457
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q14457	BECN1	ENSP00000355231	BECN1	Q14457
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BECN1	ENSP00000355231	604378	Q14457	PA25337

Protein: BECN1