ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	TE125T	Cell Line	SOFT TISSUE	NP_004041	c.454G>T	p.G152W	CCLE	NP	NP
2	134398	Tumour	LUNG	ENST00000250405	c.19G>A	p.A7T	COSMIC	NP	NP
3	Br09P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000250405	c.392A>G	p.E131G	COSMIC	NP	NP
4	LC	Tumour	S15 LUNG	ENST00000250405	c.221C>T	p.S74L	COSMIC	NP	NP
5	LUAD	Tumour	E01086 LUNG	ENST00000250405	c.20C>T	p.A7V	COSMIC	NP	NP
6	LUAD-F00368	Tumour	LUNG	ENST00000250405	c.422G>T	p.S141I	COSMIC	NP	NP
7	PR-09-3566	Tumour	PROSTATE	ENST00000250405	c.140G>A	p.R47Q	COSMIC	NP	NP
8	S00936	Tumour	LUNG	ENST00000250405	c.476C>T	p.A159V	COSMIC	NP	NP
9	S00936	Tumour	LUNG	ENST00000250405	c.478C>T	p.R160W	COSMIC	NP	NP
10	T155	Tumour	ENDOMETRIUM	ENST00000250405	c.160G>A	p.E54K	COSMIC	NP	NP
11	TCGA-36-2547-01	Tumour	OVARY	ENST00000250405	c.100G>T	p.G34W	COSMIC	NP	NP
12	TCGA-60-2722-01	Tumour	LUNG	ENST00000250405	c.276C>T	p.N92N	COSMIC	NP	NP
13	TCGA-A6-5661-01	Tumour	LARGE INTESTINE	ENST00000250405	c.529G>C	p.A177P	COSMIC	NP	NP
14	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000250405	c.284G>A	p.R95H	COSMIC	NP	NP
15	TCGA-AR-A24Q-01	Tumour	BREAST	ENST00000250405	c.433-1G>A	p.?	COSMIC	NP	NP
16	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000250405	c.250G>A	p.D84N	COSMIC	NP	NP
17	TCGA-D5-6927-01	Tumour	LARGE INTESTINE	ENST00000250405	c.505T>C	p.S169P	COSMIC	NP	NP
18	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000250405	c.477G>A	p.A159A	COSMIC	NP	NP
19	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000250405	c.94G>A	p.G32S	COSMIC	PASSENGER/OTHER	BENIGN
20	HS766T	Cell Line	PANCREAS	ENST00000250405	c.18G>A	p.S6S	COSMIC	NP	NP
21	HT115	Cell Line	LARGE_INTESTINE	ENST00000250405	c.176G>A	p.R59H	COSMIC	PASSENGER/OTHER	BENIGN
22	NCIH2342	Cell Line	LUNG	ENST00000250405	c.148G>A	p.G50R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
23	NCIH2342	Cell Line	LUNG	ENST00000250405	c.149G>T	p.G50V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
24	NCIH2342	Cell Line	LUNG	ENST00000250405	c.66G>A	p.L22L	COSMIC	NP	NP
25	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000250405	c.379G>A	p.V127M	COSMIC	PASSENGER/OTHER	BENIGN
26	SKHEP1	Cell Line	LIVER	ENST00000250405	c.482G>A	p.R161H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
27	SKMEL2	Cell Line	SKIN	ENST00000250405	c.65T>G	p.L22R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
28	TE125T	Cell Line	SOFT TISSUE	NP_004041	c.454G>T	p.G152W	CCLE	NP	NP
29	134398	Tumour	LUNG	ENST00000250405	c.19G>A	p.A7T	COSMIC	NP	NP
30	Br09P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000250405	c.392A>G	p.E131G	COSMIC	NP	NP
31	LC	Tumour	S15 LUNG	ENST00000250405	c.221C>T	p.S74L	COSMIC	NP	NP
32	LUAD	Tumour	E01086 LUNG	ENST00000250405	c.20C>T	p.A7V	COSMIC	NP	NP
33	LUAD-F00368	Tumour	LUNG	ENST00000250405	c.422G>T	p.S141I	COSMIC	NP	NP
34	PR-09-3566	Tumour	PROSTATE	ENST00000250405	c.140G>A	p.R47Q	COSMIC	NP	NP
35	S00936	Tumour	LUNG	ENST00000250405	c.476C>T	p.A159V	COSMIC	NP	NP
36	S00936	Tumour	LUNG	ENST00000250405	c.478C>T	p.R160W	COSMIC	NP	NP
37	T155	Tumour	ENDOMETRIUM	ENST00000250405	c.160G>A	p.E54K	COSMIC	NP	NP
38	TCGA-36-2547-01	Tumour	OVARY	ENST00000250405	c.100G>T	p.G34W	COSMIC	NP	NP
39	TCGA-60-2722-01	Tumour	LUNG	ENST00000250405	c.276C>T	p.N92N	COSMIC	NP	NP
40	TCGA-A6-5661-01	Tumour	LARGE INTESTINE	ENST00000250405	c.529G>C	p.A177P	COSMIC	NP	NP
41	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000250405	c.284G>A	p.R95H	COSMIC	NP	NP
42	TCGA-AR-A24Q-01	Tumour	BREAST	ENST00000250405	c.433-1G>A	p.?	COSMIC	NP	NP
43	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000250405	c.250G>A	p.D84N	COSMIC	NP	NP
44	TCGA-D5-6927-01	Tumour	LARGE INTESTINE	ENST00000250405	c.505T>C	p.S169P	COSMIC	NP	NP
45	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000250405	c.477G>A	p.A159A	COSMIC	NP	NP
46	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000250405	c.94G>A	p.G32S	COSMIC	PASSENGER/OTHER	BENIGN
47	HS766T	Cell Line	PANCREAS	ENST00000250405	c.18G>A	p.S6S	COSMIC	NP	NP
48	HT115	Cell Line	LARGE_INTESTINE	ENST00000250405	c.176G>A	p.R59H	COSMIC	PASSENGER/OTHER	BENIGN
49	NCIH2342	Cell Line	LUNG	ENST00000250405	c.148G>A	p.G50R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
50	NCIH2342	Cell Line	LUNG	ENST00000250405	c.149G>T	p.G50V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
51	NCIH2342	Cell Line	LUNG	ENST00000250405	c.66G>A	p.L22L	COSMIC	NP	NP
52	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000250405	c.379G>A	p.V127M	COSMIC	PASSENGER/OTHER	BENIGN
53	SKHEP1	Cell Line	LIVER	ENST00000250405	c.482G>A	p.R161H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
54	SKMEL2	Cell Line	SKIN	ENST00000250405	c.65T>G	p.L22R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.9509	5.9392	-0.0477	-0.0559
BILIARY TRACT	6.3174	6.0463	0.2259	0.3755
BONE	6.3172	6.2506	-0.0887	-0.0098
BREAST	6.3845	6.318	0.0348	0.0029515
CENTRAL NERVOUS SYSTEM	5.9932	5.9699	-0.2150	-0.1614
ENDOMETRIUM	6.1529	6.1633	0.0196	0.01922
HAEMATOPOIETIC AND LYMPHOID TISSUE	5.3013	5.4365	-0.0579	-0.0037
KIDNEY	5.4946	5.4115	-0.5664	-0.6919
LARGE INTESTINE	6.2352	6.2016	0.0180	0.0032325
LIVER	5.8801	5.7996	0.1518	0.06549
LUNG	6.2520	6.25635	0.1441	0.15655
OESOPHAGUS	6.3811	6.26655	-0.0065	-0.11685
OVARY	6.0803	6.0338	0.0049	0.02578
PANCREAS	6.3039	6.2246	-0.0226	0.1059
PLEURA	6.0375	6.031	-0.1310	2e-04
PROSTATE	6.4171	6.3665	0.0079	0.0166565
SALIVARY GLAND	6.2422	6.2422	-0.0549	-0.0549
SKIN	6.3416	6.3211	-0.1289	-0.05043
SMALL INTESTINE	6.4127	6.4127	0.0197	0.0197
SOFT TISSUE	6.3881	6.35795	0.1514	0.029445
STOMACH	6.4566	6.44795	0.0536	-0.0222
THYROID	6.3122	6.3133	0.2175	0.1116
UPPER AERODIGESTIVE TRACT	6.6625	6.67865	0.0988	0.08638
URINARY TRACT	6.3404	6.3458	0.0844	0.040345

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1MK3, 1O0L, 1ZY3, 2Y6W

Structure Domains (+)

1. PFAM domains are not present!!

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BCL2L2	BCL2L2	BCL2L2	ENSP00000250405	Q92843
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q92843	BCL2L2	ENSP00000250405	BCL2L2	Q92843
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BCL2L2	ENSP00000250405	601931	Q92843	PA166049089

Protein: BCL2L2

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)