ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	CHC320T	Tumour	LIVER	ENST00000317582	c.296C>T	p.S99L	COSMIC	NP	NP
2	LC	Tumour	C4 LUNG	ENST00000317582	c.1307C>T	p.P436L	COSMIC	NP	NP
3	LUAD-S01315	Tumour	LUNG	ENST00000317582	c.1124C>G	p.S375C	COSMIC	NP	NP
4	MCF7	Cell Line	BREAST	ENST00000317582	c.14delC	p.S5fs*40	COSMIC	NP	NP
5	ME009T	Tumour	SKIN	ENST00000317582	c.1169C>T	p.T390I	COSMIC	NP	NP
6	MZ7-mel	Cell Line	SKIN	ENST00000317582	c.878G>A	p.G293E	COSMIC	NP	NP
7	NCI-H2009	Cell Line	LUNG	ENST00000317582	c.230-3C>T	p.?	COSMIC	NP	NP
8	TCGA-02-0083-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000317582	c.1316G>A	p.G439D	COSMIC	NP	NP
9	TCGA-13-1494-01	Tumour	OVARY	ENST00000317582	c.948C>T	p.P316P	COSMIC	NP	NP
10	TCGA-18-3409-01	Tumour	LUNG	ENST00000317582	c.409C>T	p.R137W	COSMIC	NP	NP
11	TCGA-61-2610-02	Tumour	OVARY	ENST00000317582	c.113C>A	p.S38*	COSMIC	NP	NP
12	TCGA-A2-A0YT-01	Tumour	BREAST	ENST00000317582	c.509G>A	p.R170H	COSMIC	NP	NP
13	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000317582	c.219A>C	p.E73D	COSMIC	NP	NP
14	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000317582	c.569C>T	p.S190L	COSMIC	NP	NP
15	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000317582	c.6G>A	p.A2A	COSMIC	NP	NP
16	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000317582	c.55G>A	p.V19I	COSMIC	NP	NP
17	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000317582	c.792_795delAGAA	p.E265fs*6	COSMIC	NP	NP
18	TCGA-B6-A0IG-01	Tumour	BREAST	ENST00000317582	c.815G>T	p.G272V	COSMIC	NP	NP
19	TCGA-BT-A20P-01	Tumour	URINARY TRACT	ENST00000317582	c.234C>T	p.F78F	COSMIC	NP	NP
20	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000317582	c.992C>T	p.A331V	COSMIC	NP	NP
21	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000317582	c.1245C>T	p.N415N	COSMIC	NP	NP
22	TCGA-DK-A1A3-01	Tumour	URINARY TRACT	ENST00000317582	c.748G>C	p.E250Q	COSMIC	NP	NP
23	TCGA-DK-A3IV-01	Tumour	URINARY TRACT	ENST00000317582	c.1290G>A	p.E430E	COSMIC	NP	NP
24	TCGA-G2-A2ES-01	Tumour	URINARY TRACT	ENST00000317582	c.485A>C	p.Q162P	COSMIC	NP	NP
25	cSCCP7	Tumour	SKIN	ENST00000317582	c.1015C>T	p.P339S	COSMIC	NP	NP
26	pfg019T	Tumour	STOMACH	ENST00000317582	c.6G>A	p.A2A	COSMIC	NP	NP
27	639V	Cell Line	URINARY_TRACT	ENST00000317582	c.1299C>T	p.P433P	COSMIC	NP	NP
28	EW18	Cell Line	BONE	ENST00000317582	c.1354A>G	p.M452V	COSMIC	PASSENGER/OTHER	BENIGN
29	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000317582	c.819T>C	p.P273P	COSMIC	NP	NP
30	HCT116	Cell Line	LARGE_INTESTINE	ENST00000317582	c.646A>G	p.I216V	COSMIC	PASSENGER/OTHER	BENIGN
31	MCF7	Cell Line	BREAST	ENST00000317582	c.14delC	p.S5fs*40	COSMIC	NP	NP
32	MSTO211H	Cell Line	PLEURA	ENST00000317582	c.654A>C	p.A218A	COSMIC	NP	NP
33	MZ7MEL	Cell Line	SKIN	ENST00000317582	c.878G>A	p.G293E	COSMIC	CANCER	BENIGN
34	NCIH1573	Cell Line	LUNG	ENST00000317582	c.1458G>C	p.*486Y	COSMIC	NP	NP
35	NCIH2009	Cell Line	LUNG	ENST00000317582	c.230-3C>T	p.?	COSMIC	NP	NP
36	SNU398	Cell Line	LIVER	ENST00000317582	c.1307C>T	p.P436L	COSMIC	PASSENGER/OTHER	BENIGN
37	TE8	Cell Line	OESOPHAGUS	ENST00000317582	c.1304C>T	p.P435L	COSMIC	PASSENGER/OTHER	BENIGN
38	CHC320T	Tumour	LIVER	ENST00000317582	c.296C>T	p.S99L	COSMIC	NP	NP
39	LC	Tumour	C4 LUNG	ENST00000317582	c.1307C>T	p.P436L	COSMIC	NP	NP
40	LUAD-S01315	Tumour	LUNG	ENST00000317582	c.1124C>G	p.S375C	COSMIC	NP	NP
41	MCF7	Cell Line	BREAST	ENST00000317582	c.14delC	p.S5fs*40	COSMIC	NP	NP
42	ME009T	Tumour	SKIN	ENST00000317582	c.1169C>T	p.T390I	COSMIC	NP	NP
43	MZ7-mel	Cell Line	SKIN	ENST00000317582	c.878G>A	p.G293E	COSMIC	NP	NP
44	NCI-H2009	Cell Line	LUNG	ENST00000317582	c.230-3C>T	p.?	COSMIC	NP	NP
45	TCGA-02-0083-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000317582	c.1316G>A	p.G439D	COSMIC	NP	NP
46	TCGA-13-1494-01	Tumour	OVARY	ENST00000317582	c.948C>T	p.P316P	COSMIC	NP	NP
47	TCGA-18-3409-01	Tumour	LUNG	ENST00000317582	c.409C>T	p.R137W	COSMIC	NP	NP
48	TCGA-61-2610-02	Tumour	OVARY	ENST00000317582	c.113C>A	p.S38*	COSMIC	NP	NP
49	TCGA-A2-A0YT-01	Tumour	BREAST	ENST00000317582	c.509G>A	p.R170H	COSMIC	NP	NP
50	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000317582	c.219A>C	p.E73D	COSMIC	NP	NP
51	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000317582	c.569C>T	p.S190L	COSMIC	NP	NP
52	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000317582	c.6G>A	p.A2A	COSMIC	NP	NP
53	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000317582	c.55G>A	p.V19I	COSMIC	NP	NP
54	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000317582	c.792_795delAGAA	p.E265fs*6	COSMIC	NP	NP
55	TCGA-B6-A0IG-01	Tumour	BREAST	ENST00000317582	c.815G>T	p.G272V	COSMIC	NP	NP
56	TCGA-BT-A20P-01	Tumour	URINARY TRACT	ENST00000317582	c.234C>T	p.F78F	COSMIC	NP	NP
57	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000317582	c.992C>T	p.A331V	COSMIC	NP	NP
58	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000317582	c.1245C>T	p.N415N	COSMIC	NP	NP
59	TCGA-DK-A1A3-01	Tumour	URINARY TRACT	ENST00000317582	c.748G>C	p.E250Q	COSMIC	NP	NP
60	TCGA-DK-A3IV-01	Tumour	URINARY TRACT	ENST00000317582	c.1290G>A	p.E430E	COSMIC	NP	NP
61	TCGA-G2-A2ES-01	Tumour	URINARY TRACT	ENST00000317582	c.485A>C	p.Q162P	COSMIC	NP	NP
62	cSCCP7	Tumour	SKIN	ENST00000317582	c.1015C>T	p.P339S	COSMIC	NP	NP
63	pfg019T	Tumour	STOMACH	ENST00000317582	c.6G>A	p.A2A	COSMIC	NP	NP
64	639V	Cell Line	URINARY_TRACT	ENST00000317582	c.1299C>T	p.P433P	COSMIC	NP	NP
65	EW18	Cell Line	BONE	ENST00000317582	c.1354A>G	p.M452V	COSMIC	PASSENGER/OTHER	BENIGN
66	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000317582	c.819T>C	p.P273P	COSMIC	NP	NP
67	HCT116	Cell Line	LARGE_INTESTINE	ENST00000317582	c.646A>G	p.I216V	COSMIC	PASSENGER/OTHER	BENIGN
68	MCF7	Cell Line	BREAST	ENST00000317582	c.14delC	p.S5fs*40	COSMIC	NP	NP
69	MSTO211H	Cell Line	PLEURA	ENST00000317582	c.654A>C	p.A218A	COSMIC	NP	NP
70	MZ7MEL	Cell Line	SKIN	ENST00000317582	c.878G>A	p.G293E	COSMIC	CANCER	BENIGN
71	NCIH1573	Cell Line	LUNG	ENST00000317582	c.1458G>C	p.*486Y	COSMIC	NP	NP
72	NCIH2009	Cell Line	LUNG	ENST00000317582	c.230-3C>T	p.?	COSMIC	NP	NP
73	SNU398	Cell Line	LIVER	ENST00000317582	c.1307C>T	p.P436L	COSMIC	PASSENGER/OTHER	BENIGN
74	TE8	Cell Line	OESOPHAGUS	ENST00000317582	c.1304C>T	p.P435L	COSMIC	PASSENGER/OTHER	BENIGN

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.7522	7.7428	0.0568	0.01112
BILIARY TRACT	7.9397	7.8768	-0.0496	-0.1551
BONE	8.0205	8.1017	-0.0529	-0.0351
BREAST	8.0656	8.07345	-0.1031	-0.06167
CENTRAL NERVOUS SYSTEM	8.1671	8.1286	-0.1172	-0.0872
ENDOMETRIUM	8.0370	8.1032	-0.0485	0.0214
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.9685	7.9625	-0.0003	0.0463
KIDNEY	8.4204	8.4848	0.0078	0.0299
LARGE INTESTINE	8.0279	8.02045	-0.1123	-0.02016
LIVER	8.0014	7.9841	0.1466	0.109
LUNG	7.9976	8.0087	-0.1062	-0.0633
OESOPHAGUS	8.5777	8.6822	0.1039	0.096375
OVARY	7.9415	7.8574	-0.1514	-0.0857
PANCREAS	8.1140	8.1475	-0.1001	-0.07429
PLEURA	8.5144	8.2722	-0.0954	-0.1048
PROSTATE	8.2219	8.21245	-0.0803	-0.01035
SALIVARY GLAND	8.5108	8.5108	0.5790	0.579
SKIN	8.6169	8.55	0.2181	0.1656
SMALL INTESTINE	7.9201	7.9201	0.1500	0.15
SOFT TISSUE	8.0809	8.13365	-0.0180	0.02915
STOMACH	8.0447	7.9769	-0.0662	-0.07865
THYROID	7.7898	7.7703	-0.0566	0.04785
UPPER AERODIGESTIVE TRACT	8.3890	8.34115	0.0713	0.03704
URINARY TRACT	8.1585	8.0801	-0.0019	0.03795

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BCL2L13	BCL2L13	BCL2L13	ENSP00000318883	Q9BXK5
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9BXK5	BCL2L13	ENSP00000318883	BCL2L13	Q9BXK5
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BCL2L13	ENSP00000318883	NA	Q9BXK5	PA134912159

Protein: BCL2L13

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2IPD