ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	DMS273	Cell Line	LUNG	NP_619527	c.185G>T	p.G62V	CCLE	NP	NP
2	DU145	Cell Line	PROSTATE	NP_619527	c.517_518insA	p.Q173fs	CCLE	NP	NP
3	HEC6	Cell Line	ENDOMETRIUM	NP_619527	c.457C>T	p.R153W	CCLE	NP	NP
4	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_619527	c.498_splice	p.R166_splice	CCLE	NP	NP
5	LK2	Cell Line	LUNG	NP_619527	c.440G>A	p.W147*	CCLE	NP	NP
6	MDAMB468	Cell Line	BREAST	NP_619527	c.254G>C	p.R85T	CCLE	NP	NP
7	PFEIFFER	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_619527	c.29C>G	p.S10C	CCLE	NP	NP
8	REH	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_619527	c.40C>T	p.R14*	CCLE	NP	NP
9	SNU1040	Cell Line	LARGE INTESTINE	NP_619527	c.553C>T	p.R185*	CCLE	NP	NP
10	SNU175	Cell Line	LARGE INTESTINE	NP_619527	c.233C>T	p.P78L	CCLE	PASSENGER/OTHER	Benign
11	SNUC5	Cell Line	LARGE INTESTINE	NP_619527	c.457C>T	p.R153W	CCLE	NP	NP
12	587224	Tumour	LARGE INTESTINE	ENST00000393256	c.62C>T	p.P21L	COSMIC	NP	NP
13	DU-145	Cell Line	PROSTATE	ENST00000393256	c.519_520insA	p.A174fs*>26	COSMIC	NP	NP
14	HCC58T	Tumour	LIVER	ENST00000393256	c.335A>C	p.K112T	COSMIC	NP	NP
15	LUAD	Tumour	E00565 LUNG	ENST00000393256	c.291C>G	p.F97L	COSMIC	NP	NP
16	LUAD	Tumour	E00565 LUNG	ENST00000393256	c.585G>C	p.W195C	COSMIC	NP	NP
17	RK096	Tumour	C01 LIVER	ENST00000393256	c.140A>G	p.N47S	COSMIC	NP	NP
18	TCGA-49-4487-01	Tumour	LUNG	ENST00000393256	c.145G>C	p.G49R	COSMIC	NP	NP
19	TCGA-50-5930-01	Tumour	LUNG	ENST00000393256	c.254G>T	p.R85I	COSMIC	NP	NP
20	TCGA-50-5930-01	Tumour	LUNG	ENST00000393256	c.563G>T	p.R188L	COSMIC	NP	NP
21	TCGA-A5-A0G3-01	Tumour	ENDOMETRIUM	ENST00000393256	c.458G>C	p.R153P	COSMIC	NP	NP
22	TCGA-A5-A0GU-01	Tumour	ENDOMETRIUM	ENST00000393256	c.526G>A	p.E176K	COSMIC	NP	NP
23	TCGA-A6-6781-01	Tumour	LARGE INTESTINE	ENST00000393256	c.574C>T	p.R192C	COSMIC	NP	NP
24	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000393256	c.240_241insACA	p.F80_I81insT	COSMIC	NP	NP
25	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000393256	c.272G>A	p.R91Q	COSMIC	NP	NP
26	TCGA-AG-4015-01	Tumour	LARGE INTESTINE	ENST00000393256	c.272G>A	p.R91Q	COSMIC	NP	NP
27	TCGA-AJ-A23M-01	Tumour	ENDOMETRIUM	ENST00000393256	c.560_561insA	p.R188fs*>12	COSMIC	NP	NP
28	TCGA-AN-A0AT-01	Tumour	BREAST	ENST00000393256	c.250A>G	p.R84G	COSMIC	NP	NP
29	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000393256	c.471C>T	p.D157D	COSMIC	NP	NP
30	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000393256	c.4G>A	p.A2T	COSMIC	NP	NP
31	TCGA-AP-A0LF-01	Tumour	ENDOMETRIUM	ENST00000393256	c.251G>C	p.R84T	COSMIC	NP	NP
32	TCGA-B5-A11Y-01	Tumour	ENDOMETRIUM	ENST00000393256	c.466G>A	p.G156R	COSMIC	NP	NP
33	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000393256	c.538C>T	p.R180*	COSMIC	NP	NP
34	TCGA-D1-A176-01	Tumour	ENDOMETRIUM	ENST00000393256	c.189G>A	p.P63P	COSMIC	NP	NP
35	TCGA-D8-A1J9-01	Tumour	BREAST	ENST00000393256	c.458G>C	p.R153P	COSMIC	NP	NP
36	TCGA-E9-A1NF-01	Tumour	BREAST	ENST00000393256	c.198A>C	p.P66P	COSMIC	NP	NP
37	WA16	Tumour	PROSTATE	ENST00000393256	c.457C>T	p.R153W	COSMIC	NP	NP
38	YUWAND	Tumour	SKIN	ENST00000393256	c.146G>A	p.G49E	COSMIC	NP	NP
39	pfg019T	Tumour	STOMACH	ENST00000393256	c.294delT	p.F99fs*10	COSMIC	NP	NP
40	DMS273	Cell Line	LUNG	ENST00000393256	c.185G>T	p.G62V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
41	DU145	Cell Line	PROSTATE	ENST00000393256	c.144C>T	p.H48H	COSMIC	NP	NP
42	DU145	Cell Line	PROSTATE	ENST00000393256	c.517_518insA	p.A174fs*>26	COSMIC	NP	NP
43	H2818	Cell Line	PLEURA	ENST00000393256	c.563G>A	p.R188H	COSMIC	no weights	BENIGN
44	JHU029	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000393256	c.316G>C	p.A106P	COSMIC	PASSENGER/OTHER	BENIGN
45	LK2	Cell Line	LUNG	ENST00000393256	c.440G>A	p.W147*	COSMIC	NP	NP
46	RCCJF	Cell Line	KIDNEY	ENST00000393256	c.284G>A	p.G95E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
47	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000393256	c.40C>T	p.R14*	COSMIC	NP	NP
48	SKN	Cell Line	SOFT_TISSUE	ENST00000393256	c.591G>A	p.M197I	COSMIC	no weights	BENIGN
49	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000393256	c.553C>T	p.R185*	COSMIC	NP	NP
50	SNU175	Cell Line	LARGE_INTESTINE	ENST00000393256	c.233C>T	p.P78L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
51	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000393256	c.457C>T	p.R153W	COSMIC	no weights	PROBABLY DAMAGING
52	DMS273	Cell Line	LUNG	NP_619527	c.185G>T	p.G62V	CCLE	NP	NP
53	DU145	Cell Line	PROSTATE	NP_619527	c.517_518insA	p.Q173fs	CCLE	NP	NP
54	HEC6	Cell Line	ENDOMETRIUM	NP_619527	c.457C>T	p.R153W	CCLE	NP	NP
55	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_619527	c.498_splice	p.R166_splice	CCLE	NP	NP
56	LK2	Cell Line	LUNG	NP_619527	c.440G>A	p.W147*	CCLE	NP	NP
57	MDAMB468	Cell Line	BREAST	NP_619527	c.254G>C	p.R85T	CCLE	NP	NP
58	PFEIFFER	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_619527	c.29C>G	p.S10C	CCLE	NP	NP
59	REH	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_619527	c.40C>T	p.R14*	CCLE	NP	NP
60	SNU1040	Cell Line	LARGE INTESTINE	NP_619527	c.553C>T	p.R185*	CCLE	NP	NP
61	SNU175	Cell Line	LARGE INTESTINE	NP_619527	c.233C>T	p.P78L	CCLE	PASSENGER/OTHER	Benign
62	SNUC5	Cell Line	LARGE INTESTINE	NP_619527	c.457C>T	p.R153W	CCLE	NP	NP
63	587224	Tumour	LARGE INTESTINE	ENST00000393256	c.62C>T	p.P21L	COSMIC	NP	NP
64	DU-145	Cell Line	PROSTATE	ENST00000393256	c.519_520insA	p.A174fs*>26	COSMIC	NP	NP
65	HCC58T	Tumour	LIVER	ENST00000393256	c.335A>C	p.K112T	COSMIC	NP	NP
66	LUAD	Tumour	E00565 LUNG	ENST00000393256	c.291C>G	p.F97L	COSMIC	NP	NP
67	LUAD	Tumour	E00565 LUNG	ENST00000393256	c.585G>C	p.W195C	COSMIC	NP	NP
68	RK096	Tumour	C01 LIVER	ENST00000393256	c.140A>G	p.N47S	COSMIC	NP	NP
69	TCGA-49-4487-01	Tumour	LUNG	ENST00000393256	c.145G>C	p.G49R	COSMIC	NP	NP
70	TCGA-50-5930-01	Tumour	LUNG	ENST00000393256	c.254G>T	p.R85I	COSMIC	NP	NP
71	TCGA-50-5930-01	Tumour	LUNG	ENST00000393256	c.563G>T	p.R188L	COSMIC	NP	NP
72	TCGA-A5-A0G3-01	Tumour	ENDOMETRIUM	ENST00000393256	c.458G>C	p.R153P	COSMIC	NP	NP
73	TCGA-A5-A0GU-01	Tumour	ENDOMETRIUM	ENST00000393256	c.526G>A	p.E176K	COSMIC	NP	NP
74	TCGA-A6-6781-01	Tumour	LARGE INTESTINE	ENST00000393256	c.574C>T	p.R192C	COSMIC	NP	NP
75	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000393256	c.240_241insACA	p.F80_I81insT	COSMIC	NP	NP
76	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000393256	c.272G>A	p.R91Q	COSMIC	NP	NP
77	TCGA-AG-4015-01	Tumour	LARGE INTESTINE	ENST00000393256	c.272G>A	p.R91Q	COSMIC	NP	NP
78	TCGA-AJ-A23M-01	Tumour	ENDOMETRIUM	ENST00000393256	c.560_561insA	p.R188fs*>12	COSMIC	NP	NP
79	TCGA-AN-A0AT-01	Tumour	BREAST	ENST00000393256	c.250A>G	p.R84G	COSMIC	NP	NP
80	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000393256	c.471C>T	p.D157D	COSMIC	NP	NP
81	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000393256	c.4G>A	p.A2T	COSMIC	NP	NP
82	TCGA-AP-A0LF-01	Tumour	ENDOMETRIUM	ENST00000393256	c.251G>C	p.R84T	COSMIC	NP	NP
83	TCGA-B5-A11Y-01	Tumour	ENDOMETRIUM	ENST00000393256	c.466G>A	p.G156R	COSMIC	NP	NP
84	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000393256	c.538C>T	p.R180*	COSMIC	NP	NP
85	TCGA-D1-A176-01	Tumour	ENDOMETRIUM	ENST00000393256	c.189G>A	p.P63P	COSMIC	NP	NP
86	TCGA-D8-A1J9-01	Tumour	BREAST	ENST00000393256	c.458G>C	p.R153P	COSMIC	NP	NP
87	TCGA-E9-A1NF-01	Tumour	BREAST	ENST00000393256	c.198A>C	p.P66P	COSMIC	NP	NP
88	WA16	Tumour	PROSTATE	ENST00000393256	c.457C>T	p.R153W	COSMIC	NP	NP
89	YUWAND	Tumour	SKIN	ENST00000393256	c.146G>A	p.G49E	COSMIC	NP	NP
90	pfg019T	Tumour	STOMACH	ENST00000393256	c.294delT	p.F99fs*10	COSMIC	NP	NP
91	DMS273	Cell Line	LUNG	ENST00000393256	c.185G>T	p.G62V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
92	DU145	Cell Line	PROSTATE	ENST00000393256	c.144C>T	p.H48H	COSMIC	NP	NP
93	DU145	Cell Line	PROSTATE	ENST00000393256	c.517_518insA	p.A174fs*>26	COSMIC	NP	NP
94	H2818	Cell Line	PLEURA	ENST00000393256	c.563G>A	p.R188H	COSMIC	no weights	BENIGN
95	JHU029	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000393256	c.316G>C	p.A106P	COSMIC	PASSENGER/OTHER	BENIGN
96	LK2	Cell Line	LUNG	ENST00000393256	c.440G>A	p.W147*	COSMIC	NP	NP
97	RCCJF	Cell Line	KIDNEY	ENST00000393256	c.284G>A	p.G95E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
98	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000393256	c.40C>T	p.R14*	COSMIC	NP	NP
99	SKN	Cell Line	SOFT_TISSUE	ENST00000393256	c.591G>A	p.M197I	COSMIC	no weights	BENIGN
100	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000393256	c.553C>T	p.R185*	COSMIC	NP	NP
101	SNU175	Cell Line	LARGE_INTESTINE	ENST00000393256	c.233C>T	p.P78L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
102	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000393256	c.457C>T	p.R153W	COSMIC	no weights	PROBABLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.6745	6.6215	-0.0580	-0.0452
BILIARY TRACT	6.8622	6.9114	0.0991	0.1476
BONE	6.0024	5.9758	0.0122	0.01029
BREAST	6.8727	6.8378	-0.0551	-0.00235
CENTRAL NERVOUS SYSTEM	6.3892	6.3479	0.0224	0.0287
ENDOMETRIUM	6.7989	6.7839	0.1314	0.091
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.5042	7.4141	-0.1759	-0.0115
KIDNEY	6.4153	6.4255	0.1716	0.1406
LARGE INTESTINE	6.7731	6.7712	0.0811	0.02535
LIVER	6.5758	6.7211	0.0664	0.0671
LUNG	6.7674	6.73815	0.0513	0.06926
OESOPHAGUS	6.6436	6.54265	-0.0845	-0.0537
OVARY	6.6799	6.6232	0.1218	0.113
PANCREAS	6.8204	6.7424	0.1387	0.1513
PLEURA	6.4644	6.3783	0.1841	0.1767
PROSTATE	6.6216	6.629	-0.1650	-0.1266
SALIVARY GLAND	6.7176	6.7176	0.0822	0.0822
SKIN	6.2759	6.2317	0.0891	0.0879
SMALL INTESTINE	6.2656	6.2656	0.0529	0.05295
SOFT TISSUE	6.3663	6.33175	0.0703	0.07296
STOMACH	6.8244	6.79305	0.0005	0.01015
THYROID	6.4235	6.34915	-0.0247	-0.050995
UPPER AERODIGESTIVE TRACT	6.5079	6.4365	0.0054	0.05763
URINARY TRACT	6.7557	6.78985	0.0159	0.013665

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BCL2L11	BCL2L11	BCL2L11	ENSP00000309226	O43521
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O43521	BCL2L11	ENSP00000309226	BCL2L11	O43521
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BCL2L11	ENSP00000309226	603827	O43521	PA25305

Protein: BCL2L11

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1F95, 2K7W, 2NL9, 2V6Q, 2VM6, 2WH6, 2YQ6, 3D7V, 3FDL, 3IO8, 3IO9, 3KJ0, 3KJ1, 3KJ2, 4B4S