ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	2203	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000260442	c.287G>A	p.R96K	COSMIC	NP	NP
2	587342	Tumour	LARGE INTESTINE	ENST00000260442	c.489G>T	p.W163C	COSMIC	NP	NP
3	587376	Tumour	LARGE INTESTINE	ENST00000260442	c.562C>A	p.L188M	COSMIC	NP	NP
4	LUAD-YINHD	Tumour	LUNG	ENST00000260442	c.510C>T	p.F170F	COSMIC	NP	NP
5	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000260442	c.195C>T	p.S65S	COSMIC	NP	NP
6	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000260442	c.519C>A	p.P173P	COSMIC	NP	NP
7	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000260442	c.192C>A	p.F64L	COSMIC	NP	NP
8	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000260442	c.414C>T	p.C138C	COSMIC	NP	NP
9	ATN1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.126C>T	p.S42S	COSMIC	NP	NP
10	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.142G>A	p.V48M	COSMIC	NP	NP
11	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.156G>T	p.A52A	COSMIC	NP	NP
12	ETK1	Cell Line	BILIARY_TRACT	ENST00000260442	c.604C>A	p.R202R	COSMIC	NP	NP
13	HT115	Cell Line	LARGE_INTESTINE	ENST00000260442	c.610T>G	p.L204V	COSMIC	NP	NP
14	KO52	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.507C>T	p.F169F	COSMIC	NP	NP
15	KYSE270	Cell Line	OESOPHAGUS	ENST00000260442	c.604C>A	p.R202R	COSMIC	NP	NP
16	NCIH1155	Cell Line	LUNG	ENST00000260442	c.578C>T	p.T193I	COSMIC	NP	NP
17	NCIH2085	Cell Line	LUNG	ENST00000260442	c.490-7C>G	p.?	COSMIC	NP	NP
18	SW684	Cell Line	SOFT_TISSUE	ENST00000260442	c.502C>G	p.H168D	COSMIC	NP	NP
19	SW684	Cell Line	SOFT_TISSUE	ENST00000260442	c.523C>T	p.P175S	COSMIC	NP	NP
20	2203	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000260442	c.287G>A	p.R96K	COSMIC	NP	NP
21	587342	Tumour	LARGE INTESTINE	ENST00000260442	c.489G>T	p.W163C	COSMIC	NP	NP
22	587376	Tumour	LARGE INTESTINE	ENST00000260442	c.562C>A	p.L188M	COSMIC	NP	NP
23	LUAD-YINHD	Tumour	LUNG	ENST00000260442	c.510C>T	p.F170F	COSMIC	NP	NP
24	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000260442	c.195C>T	p.S65S	COSMIC	NP	NP
25	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000260442	c.519C>A	p.P173P	COSMIC	NP	NP
26	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000260442	c.192C>A	p.F64L	COSMIC	NP	NP
27	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000260442	c.414C>T	p.C138C	COSMIC	NP	NP
28	ATN1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.126C>T	p.S42S	COSMIC	NP	NP
29	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.142G>A	p.V48M	COSMIC	NP	NP
30	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.156G>T	p.A52A	COSMIC	NP	NP
31	ETK1	Cell Line	BILIARY_TRACT	ENST00000260442	c.604C>A	p.R202R	COSMIC	NP	NP
32	HT115	Cell Line	LARGE_INTESTINE	ENST00000260442	c.610T>G	p.L204V	COSMIC	NP	NP
33	KO52	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000260442	c.507C>T	p.F169F	COSMIC	NP	NP
34	KYSE270	Cell Line	OESOPHAGUS	ENST00000260442	c.604C>A	p.R202R	COSMIC	NP	NP
35	NCIH1155	Cell Line	LUNG	ENST00000260442	c.578C>T	p.T193I	COSMIC	NP	NP
36	NCIH2085	Cell Line	LUNG	ENST00000260442	c.490-7C>G	p.?	COSMIC	NP	NP
37	SW684	Cell Line	SOFT_TISSUE	ENST00000260442	c.502C>G	p.H168D	COSMIC	NP	NP
38	SW684	Cell Line	SOFT_TISSUE	ENST00000260442	c.523C>T	p.P175S	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.3912	4.3869	0.0682	0.013
BILIARY TRACT	4.7920	4.7891	-0.0675	-0.0495
BONE	4.3376	4.289	0.0259	0.0002166
BREAST	4.4797	4.429	-0.0826	-0.1194
CENTRAL NERVOUS SYSTEM	4.3750	4.3614	0.0260	0.05494
ENDOMETRIUM	4.4614	4.4777	-0.1436	-0.09731
HAEMATOPOIETIC AND LYMPHOID TISSUE	4.6015	4.5461	0.0097	0.0026
KIDNEY	4.4651	4.4196	-0.0822	-0.0169
LARGE INTESTINE	4.5455	4.48515	-0.0087	-0.0017751
LIVER	4.4627	4.4476	-0.0413	-0.1364
LUNG	4.5041	4.43645	-0.0654	-0.04975
OESOPHAGUS	4.5084	4.5232	-0.0141	-0.026755
OVARY	4.4704	4.4839	-0.2181	-0.08061
PANCREAS	4.5309	4.438	-0.0504	0.0196
PLEURA	4.4033	4.3543	0.0447	0.0322
PROSTATE	4.4005	4.3438	-0.0844	-0.03375
SALIVARY GLAND	5.1442	5.1442	-0.2482	-0.2482
SKIN	4.3652	4.3652	0.0046	0.003627
SMALL INTESTINE	4.5953	4.5953	-0.0034	-0.0034
SOFT TISSUE	4.4904	4.4809	-0.0994	-0.013735
STOMACH	4.5314	4.47515	-0.1392	-0.11145
THYROID	4.3640	4.3322	0.0574	0.05744
UPPER AERODIGESTIVE TRACT	4.7489	4.7405	-0.0297	0.026415
URINARY TRACT	4.6577	4.4827	-0.0030	-0.01215

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	4B4S

Structure Domains (+)

1. PFAM domains are not present!!

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BCL2L10	BCL2L10	BCL2L10	ENSP00000260442	Q9HD36
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9HD36	BCL2L10	ENSP00000260442	BCL2L10	Q9HD36
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BCL2L10	ENSP00000260442	606910	Q9HD36	PA25304

Protein: BCL2L10

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)