ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	ALEXANDERCELLS	Cell Line	LIVER	NP_612815	c.281G>T	p.G94V	CCLE	NP	NP
2	BCP1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.251C>T	p.A84V	CCLE	NP	NP
3	BT549	Cell Line	BREAST	NP_612815	c.680G>C	p.G227A	CCLE	PASSENGER/OTHER	Probably Damaging
4	COLO320	Cell Line	LARGE INTESTINE	NP_612815	c.17G>A	p.R6Q	CCLE	PASSENGER/OTHER	Benign
5	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.394C>T	p.R132W	CCLE	NP	NP
6	HT115	Cell Line	LARGE INTESTINE	NP_612815	c.96G>T	p.E32D	CCLE	NP	NP
7	HT144	Cell Line	SKIN	NP_612815	c.200G>T	p.G67V	CCLE	NP	NP
8	HT144	Cell Line	SKIN	NP_612815	c.206C>T	p.T69I	CCLE	PASSENGER/OTHER	Benign
9	HUH28	Cell Line	BILIARY TRACT	NP_612815	c.94G>C	p.E32Q	CCLE	NP	NP
10	JHH6	Cell Line	LIVER	NP_612815	c.163C>T	p.P55S	CCLE	NP	NP
11	KMS34	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.163C>T	p.P55S	CCLE	NP	NP
12	KYSE70	Cell Line	OESOPHAGUS	NP_612815	c.128C>T	p.S43L	CCLE	NP	NP
13	L428	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.408C>G	p.N136K	CCLE	NP	NP
14	NCIH1930	Cell Line	LUNG	NP_612815	c.221G>C	p.S74T	CCLE	NP	Benign
15	SH10TC	Cell Line	STOMACH	NP_612815	c.547C>T	p.Q183*	CCLE	NP	NP
16	SKLMS1	Cell Line	SOFT TISSUE	NP_612815	c.128C>T	p.S43L	CCLE	NP	NP
17	94699	Tumour	LUNG	ENST00000376062	c.177G>T	p.L59L	COSMIC	NP	NP
18	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000376062	c.598G>A	p.A200T	COSMIC	NP	NP
19	ESO-0061	Tumour	OESOPHAGUS	ENST00000376062	c.493C>T	p.R165W	COSMIC	NP	NP
20	ESO-1059	Tumour	OESOPHAGUS	ENST00000376062	c.319G>A	p.D107N	COSMIC	NP	NP
21	HN	Tumour	62298 UPPER AERODIGESTIVE TRACT	ENST00000376062	c.696G>T	p.R232R	COSMIC	NP	NP
22	PD3854a	Tumour	BREAST	ENST00000376062	c.76C>A	p.Q26K	COSMIC	NP	NP
23	SCA38	Tumour	PANCREAS	ENST00000376062	c.650G>A	p.G217D	COSMIC	NP	NP
24	SN12C	Cell Line	KIDNEY	ENST00000376062	c.443G>T	p.G148V	COSMIC	NP	NP
25	TCGA-43-6647-01	Tumour	LUNG	ENST00000376062	c.678G>C	p.L226L	COSMIC	NP	NP
26	TCGA-43-6647-01	Tumour	LUNG	ENST00000376062	c.679G>T	p.G227C	COSMIC	NP	NP
27	TCGA-55-6987-01	Tumour	LUNG	ENST00000376062	c.555C>T	p.N185N	COSMIC	NP	NP
28	TCGA-69-7978-01	Tumour	LUNG	ENST00000376062	c.363G>C	p.Q121H	COSMIC	NP	NP
29	TCGA-78-7150-01	Tumour	LUNG	ENST00000376062	c.226G>C	p.D76H	COSMIC	NP	NP
30	TCGA-AA-3845-01	Tumour	LARGE INTESTINE	ENST00000376062	c.647C>T	p.T216M	COSMIC	NP	NP
31	TCGA-AA-A01Q-01	Tumour	LARGE INTESTINE	ENST00000376062	c.384T>C	p.N128N	COSMIC	NP	NP
32	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000376062	c.149C>T	p.A50V	COSMIC	NP	NP
33	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000376062	c.593A>G	p.N198S	COSMIC	NP	NP
34	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000376062	c.524A>C	p.N175T	COSMIC	NP	NP
35	TCGA-BT-A20N-01	Tumour	URINARY TRACT	ENST00000376062	c.446C>A	p.A149E	COSMIC	NP	NP
36	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000376062	c.631A>G	p.N211D	COSMIC	NP	NP
37	TCGA-D8-A145-01	Tumour	BREAST	ENST00000376062	c.447A>T	p.A149A	COSMIC	NP	NP
38	TCGA-DK-A1AC-01	Tumour	URINARY TRACT	ENST00000376062	c.90G>A	p.V30V	COSMIC	NP	NP
39	BT549	Cell Line	BREAST	ENST00000376062	c.680G>C	p.G227A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
40	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.630C>T	p.F210F	COSMIC	NP	NP
41	D247MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000376062	c.212A>G	p.H71R	COSMIC	PASSENGER/OTHER	BENIGN
42	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.30T>C	p.V10V	COSMIC	NP	NP
43	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.394C>T	p.R132W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
44	DOTC24510	Cell Line	CERVIX	ENST00000376062	c.251C>A	p.A84E	COSMIC	PASSENGER/OTHER	BENIGN
45	HAL01	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.381G>T	p.V127V	COSMIC	NP	NP
46	HN	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000376062	c.456G>A	p.V152V	COSMIC	NP	NP
47	HSC4	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000376062	c.456G>A	p.V152V	COSMIC	NP	NP
48	HT115	Cell Line	LARGE_INTESTINE	ENST00000376062	c.96G>T	p.E32D	COSMIC	PASSENGER/OTHER	BENIGN
49	HT144	Cell Line	SKIN	ENST00000376062	c.200G>T	p.G67V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
50	HT144	Cell Line	SKIN	ENST00000376062	c.206C>T	p.T69I	COSMIC	PASSENGER/OTHER	BENIGN
51	JHH6	Cell Line	LIVER	ENST00000376062	c.163C>T	p.P55S	COSMIC	PASSENGER/OTHER	BENIGN
52	KYSE70	Cell Line	OESOPHAGUS	ENST00000376062	c.128C>T	p.S43L	COSMIC	PASSENGER/OTHER	BENIGN
53	L428	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.408C>G	p.N136K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
54	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.381G>A	p.V127V	COSMIC	NP	NP
55	PFSK1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000376062	c.565-3C>A	p.?	COSMIC	NP	NP
56	RS411	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.190G>A	p.A64T	COSMIC	PASSENGER/OTHER	BENIGN
57	SKLMS1	Cell Line	SOFT_TISSUE	ENST00000376062	c.128C>T	p.S43L	COSMIC	PASSENGER/OTHER	BENIGN
58	SN12C	Cell Line	KIDNEY	ENST00000376062	c.443G>T	p.G148V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
59	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000376062	c.524A>T	p.N175I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
60	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000376062	c.179C>T	p.A60V	COSMIC	PASSENGER/OTHER	BENIGN
61	SW13	Cell Line	ADRENAL_GLAND	ENST00000376062	c.229G>A	p.A77T	COSMIC	PASSENGER/OTHER	BENIGN
62	SW13	Cell Line	ADRENAL_GLAND	ENST00000376062	c.230C>T	p.A77V	COSMIC	PASSENGER/OTHER	BENIGN
63	TE15	Cell Line	OESOPHAGUS	ENST00000376062	c.447A>G	p.A149A	COSMIC	NP	NP
64	ALEXANDERCELLS	Cell Line	LIVER	NP_612815	c.281G>T	p.G94V	CCLE	NP	NP
65	BCP1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.251C>T	p.A84V	CCLE	NP	NP
66	BT549	Cell Line	BREAST	NP_612815	c.680G>C	p.G227A	CCLE	PASSENGER/OTHER	Probably Damaging
67	COLO320	Cell Line	LARGE INTESTINE	NP_612815	c.17G>A	p.R6Q	CCLE	PASSENGER/OTHER	Benign
68	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.394C>T	p.R132W	CCLE	NP	NP
69	HT115	Cell Line	LARGE INTESTINE	NP_612815	c.96G>T	p.E32D	CCLE	NP	NP
70	HT144	Cell Line	SKIN	NP_612815	c.200G>T	p.G67V	CCLE	NP	NP
71	HT144	Cell Line	SKIN	NP_612815	c.206C>T	p.T69I	CCLE	PASSENGER/OTHER	Benign
72	HUH28	Cell Line	BILIARY TRACT	NP_612815	c.94G>C	p.E32Q	CCLE	NP	NP
73	JHH6	Cell Line	LIVER	NP_612815	c.163C>T	p.P55S	CCLE	NP	NP
74	KMS34	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.163C>T	p.P55S	CCLE	NP	NP
75	KYSE70	Cell Line	OESOPHAGUS	NP_612815	c.128C>T	p.S43L	CCLE	NP	NP
76	L428	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_612815	c.408C>G	p.N136K	CCLE	NP	NP
77	NCIH1930	Cell Line	LUNG	NP_612815	c.221G>C	p.S74T	CCLE	NP	Benign
78	SH10TC	Cell Line	STOMACH	NP_612815	c.547C>T	p.Q183*	CCLE	NP	NP
79	SKLMS1	Cell Line	SOFT TISSUE	NP_612815	c.128C>T	p.S43L	CCLE	NP	NP
80	94699	Tumour	LUNG	ENST00000376062	c.177G>T	p.L59L	COSMIC	NP	NP
81	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000376062	c.598G>A	p.A200T	COSMIC	NP	NP
82	ESO-0061	Tumour	OESOPHAGUS	ENST00000376062	c.493C>T	p.R165W	COSMIC	NP	NP
83	ESO-1059	Tumour	OESOPHAGUS	ENST00000376062	c.319G>A	p.D107N	COSMIC	NP	NP
84	HN	Tumour	62298 UPPER AERODIGESTIVE TRACT	ENST00000376062	c.696G>T	p.R232R	COSMIC	NP	NP
85	PD3854a	Tumour	BREAST	ENST00000376062	c.76C>A	p.Q26K	COSMIC	NP	NP
86	SCA38	Tumour	PANCREAS	ENST00000376062	c.650G>A	p.G217D	COSMIC	NP	NP
87	SN12C	Cell Line	KIDNEY	ENST00000376062	c.443G>T	p.G148V	COSMIC	NP	NP
88	TCGA-43-6647-01	Tumour	LUNG	ENST00000376062	c.678G>C	p.L226L	COSMIC	NP	NP
89	TCGA-43-6647-01	Tumour	LUNG	ENST00000376062	c.679G>T	p.G227C	COSMIC	NP	NP
90	TCGA-55-6987-01	Tumour	LUNG	ENST00000376062	c.555C>T	p.N185N	COSMIC	NP	NP
91	TCGA-69-7978-01	Tumour	LUNG	ENST00000376062	c.363G>C	p.Q121H	COSMIC	NP	NP
92	TCGA-78-7150-01	Tumour	LUNG	ENST00000376062	c.226G>C	p.D76H	COSMIC	NP	NP
93	TCGA-AA-3845-01	Tumour	LARGE INTESTINE	ENST00000376062	c.647C>T	p.T216M	COSMIC	NP	NP
94	TCGA-AA-A01Q-01	Tumour	LARGE INTESTINE	ENST00000376062	c.384T>C	p.N128N	COSMIC	NP	NP
95	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000376062	c.149C>T	p.A50V	COSMIC	NP	NP
96	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000376062	c.593A>G	p.N198S	COSMIC	NP	NP
97	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000376062	c.524A>C	p.N175T	COSMIC	NP	NP
98	TCGA-BT-A20N-01	Tumour	URINARY TRACT	ENST00000376062	c.446C>A	p.A149E	COSMIC	NP	NP
99	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000376062	c.631A>G	p.N211D	COSMIC	NP	NP
100	TCGA-D8-A145-01	Tumour	BREAST	ENST00000376062	c.447A>T	p.A149A	COSMIC	NP	NP
101	TCGA-DK-A1AC-01	Tumour	URINARY TRACT	ENST00000376062	c.90G>A	p.V30V	COSMIC	NP	NP
102	BT549	Cell Line	BREAST	ENST00000376062	c.680G>C	p.G227A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
103	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.630C>T	p.F210F	COSMIC	NP	NP
104	D247MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000376062	c.212A>G	p.H71R	COSMIC	PASSENGER/OTHER	BENIGN
105	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.30T>C	p.V10V	COSMIC	NP	NP
106	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.394C>T	p.R132W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
107	DOTC24510	Cell Line	CERVIX	ENST00000376062	c.251C>A	p.A84E	COSMIC	PASSENGER/OTHER	BENIGN
108	HAL01	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.381G>T	p.V127V	COSMIC	NP	NP
109	HN	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000376062	c.456G>A	p.V152V	COSMIC	NP	NP
110	HSC4	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000376062	c.456G>A	p.V152V	COSMIC	NP	NP
111	HT115	Cell Line	LARGE_INTESTINE	ENST00000376062	c.96G>T	p.E32D	COSMIC	PASSENGER/OTHER	BENIGN
112	HT144	Cell Line	SKIN	ENST00000376062	c.200G>T	p.G67V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
113	HT144	Cell Line	SKIN	ENST00000376062	c.206C>T	p.T69I	COSMIC	PASSENGER/OTHER	BENIGN
114	JHH6	Cell Line	LIVER	ENST00000376062	c.163C>T	p.P55S	COSMIC	PASSENGER/OTHER	BENIGN
115	KYSE70	Cell Line	OESOPHAGUS	ENST00000376062	c.128C>T	p.S43L	COSMIC	PASSENGER/OTHER	BENIGN
116	L428	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.408C>G	p.N136K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
117	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.381G>A	p.V127V	COSMIC	NP	NP
118	PFSK1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000376062	c.565-3C>A	p.?	COSMIC	NP	NP
119	RS411	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000376062	c.190G>A	p.A64T	COSMIC	PASSENGER/OTHER	BENIGN
120	SKLMS1	Cell Line	SOFT_TISSUE	ENST00000376062	c.128C>T	p.S43L	COSMIC	PASSENGER/OTHER	BENIGN
121	SN12C	Cell Line	KIDNEY	ENST00000376062	c.443G>T	p.G148V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
122	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000376062	c.524A>T	p.N175I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
123	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000376062	c.179C>T	p.A60V	COSMIC	PASSENGER/OTHER	BENIGN
124	SW13	Cell Line	ADRENAL_GLAND	ENST00000376062	c.229G>A	p.A77T	COSMIC	PASSENGER/OTHER	BENIGN
125	SW13	Cell Line	ADRENAL_GLAND	ENST00000376062	c.230C>T	p.A77V	COSMIC	PASSENGER/OTHER	BENIGN
126	TE15	Cell Line	OESOPHAGUS	ENST00000376062	c.447A>G	p.A149A	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.5462	5.5452	0.0884	0.01777
BILIARY TRACT	7.4422	7.0419	0.2002	0.2557
BONE	6.3986	6.5254	0.0815	-0.004
BREAST	6.8758	6.8688	0.3333	0.2878
CENTRAL NERVOUS SYSTEM	6.8343	6.652	0.2969	0.2455
ENDOMETRIUM	7.2106	7.2729	0.1666	0.0311
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.4463	6.2997	0.1125	0.0265
KIDNEY	7.6980	7.8808	0.1999	0.1872
LARGE INTESTINE	7.4144	7.3981	0.3223	0.2237
LIVER	7.3613	7.4365	0.4692	0.5167
LUNG	6.8782	6.91495	0.3335	0.279
OESOPHAGUS	6.9918	7.0839	0.4533	0.41875
OVARY	7.2922	7.4053	0.3199	0.2618
PANCREAS	7.8317	7.8622	0.4160	0.3582
PLEURA	7.3163	7.2991	0.3821	0.3388
PROSTATE	6.9903	6.84385	0.1263	0.10135
SALIVARY GLAND	5.7654	5.7654	0.3842	0.3842
SKIN	6.0440	5.9847	0.3479	0.3456
SMALL INTESTINE	6.0463	6.0463	0.0145	0.0145
SOFT TISSUE	6.3550	6.3152	0.2485	0.2901
STOMACH	7.5143	7.6311	0.4004	0.40195
THYROID	6.7559	6.6325	0.5213	0.5006
UPPER AERODIGESTIVE TRACT	6.9900	7.1786	0.4194	0.3693
URINARY TRACT	7.3406	7.2268	0.5614	0.5301

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BCL2L1	BCL2L1	BCL2L1	ENSP00000302564	Q07817
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q07817	BCL2L1	ENSP00000302564	BCL2L1	Q07817
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BCL2L1	ENSP00000302564	600039	Q07817	PA76

Protein: BCL2L1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4EHR, 4HNJ, 4IEH