ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	GP2D	Cell Line	LARGE INTESTINE	NP_004040	c.359A>G	p.Y120C	CCLE	NP	NP
2	HEC251	Cell Line	ENDOMETRIUM	NP_004040	c.139G>T	p.E47*	CCLE	NP	NP
3	HEC251	Cell Line	ENDOMETRIUM	NP_004040	c.447A>T	p.E149D	CCLE	NP	NP
4	587270	Tumour	LARGE INTESTINE	ENST00000267953	c.368C>T	p.A123V	COSMIC	NP	NP
5	587376	Tumour	LARGE INTESTINE	ENST00000267953	c.139G>T	p.E47*	COSMIC	NP	NP
6	HN	Tumour	62506 UPPER AERODIGESTIVE TRACT	ENST00000267953	c.126C>T	p.F42F	COSMIC	NP	NP
7	Pa08C	Cell Line	PANCREAS	ENST00000267953	c.428G>C	p.G143A	COSMIC	NP	NP
8	TCGA-21-1071-01	Tumour	LUNG	ENST00000267953	c.401T>G	p.I134R	COSMIC	NP	NP
9	TCGA-66-2742-01	Tumour	LUNG	ENST00000267953	c.481A>T	p.T161S	COSMIC	NP	NP
10	TCGA-66-2756-01	Tumour	LUNG	ENST00000267953	c.291T>C	p.G97G	COSMIC	NP	NP
11	TCGA-75-7031-01	Tumour	LUNG	ENST00000267953	c.139G>T	p.E47*	COSMIC	NP	NP
12	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000267953	c.411C>T	p.N137N	COSMIC	NP	NP
13	TCGA-AG-3887-01	Tumour	LARGE INTESTINE	ENST00000267953	c.358T>C	p.Y120H	COSMIC	NP	NP
14	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000267953	c.347A>C	p.K116T	COSMIC	NP	NP
15	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000267953	c.412G>T	p.G138*	COSMIC	NP	NP
16	TCGA-B8-5158-01	Tumour	KIDNEY	ENST00000267953	c.465G>A	p.M155I	COSMIC	NP	NP
17	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000267953	c.375C>A	p.F125L	COSMIC	NP	NP
18	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000267953	c.422A>C	p.E141A	COSMIC	NP	NP
19	TCGA-CZ-5457-01	Tumour	KIDNEY	ENST00000267953	c.477A>T	p.E159D	COSMIC	NP	NP
20	TCGA-D1-A176-01	Tumour	ENDOMETRIUM	ENST00000267953	c.163T>C	p.C55R	COSMIC	NP	NP
21	ccRCC-89	Tumour	KIDNEY	ENST00000267953	c.466A>G	p.T156A	COSMIC	NP	NP
22	tumor	Tumour	4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000267953	c.219A>C	p.Q73H	COSMIC	NP	NP
23	C33A	Cell Line	CERVIX	ENST00000267953	c.329C>T	p.P110L	COSMIC	PASSENGER/OTHER	BENIGN
24	EN	Cell Line	ENDOMETRIUM	ENST00000267953	c.291T>C	p.G97G	COSMIC	NP	NP
25	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000267953	c.330G>A	p.P110P	COSMIC	NP	NP
26	KYSE410	Cell Line	OESOPHAGUS	ENST00000267953	c.88C>T	p.P30S	COSMIC	PASSENGER/OTHER	BENIGN
27	KYSE410	Cell Line	OESOPHAGUS	ENST00000267953	c.89C>T	p.P30L	COSMIC	PASSENGER/OTHER	BENIGN
28	LCLC103H	Cell Line	LUNG	ENST00000267953	c.207A>C	p.T69T	COSMIC	NP	NP
29	P31FUJ	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000267953	c.252T>C	p.I84I	COSMIC	NP	NP
30	GP2D	Cell Line	LARGE INTESTINE	NP_004040	c.359A>G	p.Y120C	CCLE	NP	NP
31	HEC251	Cell Line	ENDOMETRIUM	NP_004040	c.139G>T	p.E47*	CCLE	NP	NP
32	HEC251	Cell Line	ENDOMETRIUM	NP_004040	c.447A>T	p.E149D	CCLE	NP	NP
33	587270	Tumour	LARGE INTESTINE	ENST00000267953	c.368C>T	p.A123V	COSMIC	NP	NP
34	587376	Tumour	LARGE INTESTINE	ENST00000267953	c.139G>T	p.E47*	COSMIC	NP	NP
35	HN	Tumour	62506 UPPER AERODIGESTIVE TRACT	ENST00000267953	c.126C>T	p.F42F	COSMIC	NP	NP
36	Pa08C	Cell Line	PANCREAS	ENST00000267953	c.428G>C	p.G143A	COSMIC	NP	NP
37	TCGA-21-1071-01	Tumour	LUNG	ENST00000267953	c.401T>G	p.I134R	COSMIC	NP	NP
38	TCGA-66-2742-01	Tumour	LUNG	ENST00000267953	c.481A>T	p.T161S	COSMIC	NP	NP
39	TCGA-66-2756-01	Tumour	LUNG	ENST00000267953	c.291T>C	p.G97G	COSMIC	NP	NP
40	TCGA-75-7031-01	Tumour	LUNG	ENST00000267953	c.139G>T	p.E47*	COSMIC	NP	NP
41	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000267953	c.411C>T	p.N137N	COSMIC	NP	NP
42	TCGA-AG-3887-01	Tumour	LARGE INTESTINE	ENST00000267953	c.358T>C	p.Y120H	COSMIC	NP	NP
43	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000267953	c.347A>C	p.K116T	COSMIC	NP	NP
44	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000267953	c.412G>T	p.G138*	COSMIC	NP	NP
45	TCGA-B8-5158-01	Tumour	KIDNEY	ENST00000267953	c.465G>A	p.M155I	COSMIC	NP	NP
46	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000267953	c.375C>A	p.F125L	COSMIC	NP	NP
47	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000267953	c.422A>C	p.E141A	COSMIC	NP	NP
48	TCGA-CZ-5457-01	Tumour	KIDNEY	ENST00000267953	c.477A>T	p.E159D	COSMIC	NP	NP
49	TCGA-D1-A176-01	Tumour	ENDOMETRIUM	ENST00000267953	c.163T>C	p.C55R	COSMIC	NP	NP
50	ccRCC-89	Tumour	KIDNEY	ENST00000267953	c.466A>G	p.T156A	COSMIC	NP	NP
51	tumor	Tumour	4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000267953	c.219A>C	p.Q73H	COSMIC	NP	NP
52	C33A	Cell Line	CERVIX	ENST00000267953	c.329C>T	p.P110L	COSMIC	PASSENGER/OTHER	BENIGN
53	EN	Cell Line	ENDOMETRIUM	ENST00000267953	c.291T>C	p.G97G	COSMIC	NP	NP
54	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000267953	c.330G>A	p.P110P	COSMIC	NP	NP
55	KYSE410	Cell Line	OESOPHAGUS	ENST00000267953	c.88C>T	p.P30S	COSMIC	PASSENGER/OTHER	BENIGN
56	KYSE410	Cell Line	OESOPHAGUS	ENST00000267953	c.89C>T	p.P30L	COSMIC	PASSENGER/OTHER	BENIGN
57	LCLC103H	Cell Line	LUNG	ENST00000267953	c.207A>C	p.T69T	COSMIC	NP	NP
58	P31FUJ	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000267953	c.252T>C	p.I84I	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	3.5214	3.5179	0.0485	0.0078
BILIARY TRACT	4.3237	3.9798	0.0408	0.05747
BONE	3.9449	3.639	0.0082	-0.0092
BREAST	3.9224	3.5484	-0.1034	-0.0574
CENTRAL NERVOUS SYSTEM	4.1279	3.6484	0.0591	0.0695
ENDOMETRIUM	3.7374	3.6909	-0.1541	-0.0814
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.1208	4.9062	0.0178	0.003675
KIDNEY	5.3427	3.9476	-0.0659	-0.002319
LARGE INTESTINE	3.8160	3.51475	0.0079	-0.00395
LIVER	3.9209	3.625	-0.0518	-0.0564
LUNG	4.3519	3.5734	-0.0724	-0.06004
OESOPHAGUS	3.7308	3.5297	-0.0558	-0.07981
OVARY	4.1031	3.5936	-0.1050	-0.0141
PANCREAS	4.1873	3.6586	-0.0217	0.004
PLEURA	4.4295	3.657	0.0310	0.0275
PROSTATE	4.8717	3.61735	-0.0878	-0.03605
SALIVARY GLAND	3.4634	3.4634	-0.2463	-0.2463
SKIN	8.5061	9.7356	0.1097	0.0839
SMALL INTESTINE	3.6207	3.6207	0.0156	0.0156
SOFT TISSUE	5.2182	3.7337	0.0062	-0.014225
STOMACH	3.6938	3.5383	0.0188	0.010235
THYROID	6.1916	6.13285	0.0352	0.031995
UPPER AERODIGESTIVE TRACT	4.7981	4.05545	-0.0068	0.008089
URINARY TRACT	4.0064	3.6299	-0.0451	-0.0471

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BCL2A1	BCL2A1	BCL2A1	ENSP00000267953	Q16548
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q16548	BCL2A1	ENSP00000267953	BCL2A1	Q16548
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BCL2A1	ENSP00000267953	601056	Q16548	PA25303

Protein: BCL2A1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2VM6, 3I1H, 3MQP