ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	E20	Tumour	EYE	ENST00000439096	c.465+2T>G	p.?	COSMIC	NP	NP
2	ESO-859	Tumour	OESOPHAGUS	ENST00000439096	c.564C>T	p.P188P	COSMIC	NP	NP
3	LUAD-AEIUF	Tumour	LUNG	ENST00000439096	c.559G>A	p.A187T	COSMIC	NP	NP
4	ME043T	Tumour	SKIN	ENST00000439096	c.154A>C	p.T52P	COSMIC	NP	NP
5	TCGA-18-3408-01	Tumour	LUNG	ENST00000439096	c.553C>T	p.H185Y	COSMIC	NP	NP
6	TCGA-66-2778-01	Tumour	LUNG	ENST00000439096	c.494C>T	p.P165L	COSMIC	NP	NP
7	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000439096	c.582G>T	p.*194Y	COSMIC	NP	NP
8	TCGA-AX-A06H-01	Tumour	ENDOMETRIUM	ENST00000439096	c.536T>C	p.L179P	COSMIC	NP	NP
9	TCGA-B0-5098-01	Tumour	KIDNEY	ENST00000439096	c.486G>A	p.R162R	COSMIC	NP	NP
10	E20	Tumour	EYE	ENST00000439096	c.465+2T>G	p.?	COSMIC	NP	NP
11	ESO-859	Tumour	OESOPHAGUS	ENST00000439096	c.564C>T	p.P188P	COSMIC	NP	NP
12	LUAD-AEIUF	Tumour	LUNG	ENST00000439096	c.559G>A	p.A187T	COSMIC	NP	NP
13	ME043T	Tumour	SKIN	ENST00000439096	c.154A>C	p.T52P	COSMIC	NP	NP
14	TCGA-18-3408-01	Tumour	LUNG	ENST00000439096	c.553C>T	p.H185Y	COSMIC	NP	NP
15	TCGA-66-2778-01	Tumour	LUNG	ENST00000439096	c.494C>T	p.P165L	COSMIC	NP	NP
16	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000439096	c.582G>T	p.*194Y	COSMIC	NP	NP
17	TCGA-AX-A06H-01	Tumour	ENDOMETRIUM	ENST00000439096	c.536T>C	p.L179P	COSMIC	NP	NP
18	TCGA-B0-5098-01	Tumour	KIDNEY	ENST00000439096	c.486G>A	p.R162R	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.2038	6.0729	-0.1754	-0.06591
BILIARY TRACT	6.2568	6.2064	0.2433	0.2693
BONE	5.9140	5.9285	-0.0339	-0.0006187
BREAST	6.1648	6.10935	-0.0067	0.0278
CENTRAL NERVOUS SYSTEM	5.8710	5.8149	-0.0757	-0.06021
ENDOMETRIUM	6.4097	6.426	0.0242	0.007987
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.3858	6.3474	0.0797	0.0143
KIDNEY	6.5317	6.4922	0.0055	0.0294
LARGE INTESTINE	6.5061	6.49635	-0.0089	-0.010745
LIVER	6.0332	5.9758	0.1466	0.1555
LUNG	5.9123	5.912	0.0027	0.0047
OESOPHAGUS	6.3344	6.1796	-0.0366	0.013315
OVARY	6.0666	6.0503	-0.0320	-0.0011
PANCREAS	6.2892	6.3449	-0.0568	-0.03163
PLEURA	5.9602	5.8134	-0.0638	0.04534
PROSTATE	6.1984	6.2801	-0.3737	-0.4223
SALIVARY GLAND	4.7053	4.7053	0.0672	0.06719
SKIN	5.9805	5.9947	-0.0627	-0.0195
SMALL INTESTINE	6.7107	6.7107	0.0544	0.0544
SOFT TISSUE	6.0465	6.02395	-0.0039	0.0184
STOMACH	6.3403	6.24205	0.0887	0.0115245
THYROID	5.8238	5.69125	0.0454	0.09035
UPPER AERODIGESTIVE TRACT	6.2795	6.282	-0.0905	-0.005186
URINARY TRACT	5.9153	5.83705	-0.0614	-0.07592

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

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Modelled Structure	Structures available in PDB
	2M04, 4BPI, 4BPJ, 4BPK, 4HNJ

1. PFAM Domains:

2. Superfaimly domains are not present!!

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Protein: BBC3