ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	HEC251	Cell Line	ENDOMETRIUM	NP_001179	c.8C>T	p.S3L	CCLE	PASSENGER/OTHER	Probably Damaging
2	HEC6	Cell Line	ENDOMETRIUM	NP_001179	c.163C>T	p.P55S	CCLE	PASSENGER/OTHER	Probably Damaging
3	NCIH1930	Cell Line	LUNG	NP_001179	c.627C>A	p.F209L	CCLE	PASSENGER/OTHER	Probably Damaging
4	SNU349	Cell Line	KIDNEY	NP_001179	c.116T>G	p.V39G	CCLE	PASSENGER/OTHER	Probably Damaging
5	TGBC11TKB	Cell Line	STOMACH	NP_001179	c.263G>A	p.R88H	CCLE	PASSENGER/OTHER	Probably Damaging
6	LAU618	Cell Line	SKIN	ENST00000374467	c.602G>A	p.G201D	COSMIC	NP	NP
7	LUAD-TLLGS	Tumour	LUNG	ENST00000374467	c.526G>A	p.G176S	COSMIC	NP	NP
8	TCGA-24-1470-01	Tumour	OVARY	ENST00000374467	c.114C>T	p.Y38Y	COSMIC	NP	NP
9	TCGA-A6-6781-01	Tumour	LARGE INTESTINE	ENST00000374467	c.249C>T	p.D83D	COSMIC	NP	NP
10	TCGA-A8-A09G-01	Tumour	BREAST	ENST00000374467	c.617G>A	p.R206Q	COSMIC	NP	NP
11	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000374467	c.623T>A	p.F208Y	COSMIC	NP	NP
12	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000374467	c.182T>C	p.V61A	COSMIC	NP	NP
13	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000374467	c.420A>G	p.L140L	COSMIC	NP	NP
14	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000374467	c.263G>A	p.R88H	COSMIC	NP	NP
15	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000374467	c.478G>A	p.D160N	COSMIC	NP	NP
16	TCGA-BH-A1F8-01	Tumour	BREAST	ENST00000374467	c.71-3C>T	p.?	COSMIC	NP	NP
17	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000374467	c.624C>A	p.F208L	COSMIC	NP	NP
18	2313287	Cell Line	STOMACH	ENST00000374467	c.327G>A	p.E109E	COSMIC	NP	NP
19	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.94G>A	p.E32K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
20	DG75	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.112T>C	p.Y38H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
21	H513	Cell Line	PLEURA	ENST00000374467	c.207-7C>A	p.?	COSMIC	NP	NP
22	HCC1500	Cell Line	BREAST	ENST00000374467	c.381T>C	p.R127R	COSMIC	NP	NP
23	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.107G>A	p.R36H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
24	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.207-1G>A	p.?	COSMIC	NP	NP
25	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.121delT	p.Y41fs*107	COSMIC	NP	NP
26	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.304C>T	p.P102S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
27	OC314	Cell Line	OVARY	ENST00000374467	c.466C>A	p.R156S	COSMIC	PASSENGER/OTHER	BENIGN
28	TGBC11TKB	Cell Line	STOMACH	ENST00000374467	c.263G>A	p.R88H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
29	HEC251	Cell Line	ENDOMETRIUM	NP_001179	c.8C>T	p.S3L	CCLE	PASSENGER/OTHER	Probably Damaging
30	HEC6	Cell Line	ENDOMETRIUM	NP_001179	c.163C>T	p.P55S	CCLE	PASSENGER/OTHER	Probably Damaging
31	NCIH1930	Cell Line	LUNG	NP_001179	c.627C>A	p.F209L	CCLE	PASSENGER/OTHER	Probably Damaging
32	SNU349	Cell Line	KIDNEY	NP_001179	c.116T>G	p.V39G	CCLE	PASSENGER/OTHER	Probably Damaging
33	TGBC11TKB	Cell Line	STOMACH	NP_001179	c.263G>A	p.R88H	CCLE	PASSENGER/OTHER	Probably Damaging
34	LAU618	Cell Line	SKIN	ENST00000374467	c.602G>A	p.G201D	COSMIC	NP	NP
35	LUAD-TLLGS	Tumour	LUNG	ENST00000374467	c.526G>A	p.G176S	COSMIC	NP	NP
36	TCGA-24-1470-01	Tumour	OVARY	ENST00000374467	c.114C>T	p.Y38Y	COSMIC	NP	NP
37	TCGA-A6-6781-01	Tumour	LARGE INTESTINE	ENST00000374467	c.249C>T	p.D83D	COSMIC	NP	NP
38	TCGA-A8-A09G-01	Tumour	BREAST	ENST00000374467	c.617G>A	p.R206Q	COSMIC	NP	NP
39	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000374467	c.623T>A	p.F208Y	COSMIC	NP	NP
40	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000374467	c.182T>C	p.V61A	COSMIC	NP	NP
41	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000374467	c.420A>G	p.L140L	COSMIC	NP	NP
42	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000374467	c.263G>A	p.R88H	COSMIC	NP	NP
43	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000374467	c.478G>A	p.D160N	COSMIC	NP	NP
44	TCGA-BH-A1F8-01	Tumour	BREAST	ENST00000374467	c.71-3C>T	p.?	COSMIC	NP	NP
45	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000374467	c.624C>A	p.F208L	COSMIC	NP	NP
46	2313287	Cell Line	STOMACH	ENST00000374467	c.327G>A	p.E109E	COSMIC	NP	NP
47	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.94G>A	p.E32K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
48	DG75	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.112T>C	p.Y38H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
49	H513	Cell Line	PLEURA	ENST00000374467	c.207-7C>A	p.?	COSMIC	NP	NP
50	HCC1500	Cell Line	BREAST	ENST00000374467	c.381T>C	p.R127R	COSMIC	NP	NP
51	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.107G>A	p.R36H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
52	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.207-1G>A	p.?	COSMIC	NP	NP
53	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.121delT	p.Y41fs*107	COSMIC	NP	NP
54	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000374467	c.304C>T	p.P102S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
55	OC314	Cell Line	OVARY	ENST00000374467	c.466C>A	p.R156S	COSMIC	PASSENGER/OTHER	BENIGN
56	TGBC11TKB	Cell Line	STOMACH	ENST00000374467	c.263G>A	p.R88H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Domain ID	Domain Name	Start Site	End Site	E-value
PF00452	Bcl-2	78	177	1.3e-26
PF00452	Bcl-2	78	177	1.3e-26

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BAK1	BAK1	BAK1	ENSP00000353878	Q16611
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q16611	BAK1	ENSP00000353878	BAK1	Q16611
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BAK1	ENSP00000353878	600516	Q16611	PA25253

Protein: BAK1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2M5B, 2XPX, 2YV6, 3I1H, 3QBR