ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116784	c.410C>A	p.T137K	CCLE	PASSENGER/OTHER	Probably Damaging
2	EBC1	Cell Line	LUNG	NP_116784	c.85G>A	p.D29N	CCLE	PASSENGER/OTHER	Probably Damaging
3	GP2D	Cell Line	LARGE INTESTINE	NP_116784	c.483G>T	p.R161S	CCLE	PASSENGER/OTHER	Possibly Damaging
4	HEC265	Cell Line	ENDOMETRIUM	NP_116784	c.208C>T	p.R70W	CCLE	PASSENGER/OTHER	Probably Damaging
5	JHOM1	Cell Line	OVARY	NP_116784	c.95C>T	p.S32L	CCLE	PASSENGER/OTHER	Benign
6	VMCUB1	Cell Line	URINARY TRACT	NP_116784	c.491C>T	p.S164F	CCLE	PASSENGER/OTHER	Benign
7	587278	Tumour	LARGE INTESTINE	ENST00000394532	c.301C>T	p.P101S	COSMIC	NP	NP
8	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000394532	c.371C>T	p.S124F	COSMIC	NP	NP
9	ESO-539	Tumour	OESOPHAGUS	ENST00000394532	c.379-4C>T	p.?	COSMIC	NP	NP
10	LUAD-YINHD	Tumour	LUNG	ENST00000394532	c.450C>G	p.V150V	COSMIC	NP	NP
11	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000394532	c.306delC	p.N103fs*15	COSMIC	NP	NP
12	TCGA-AO-A03U-01	Tumour	BREAST	ENST00000394532	c.288C>T	p.R96R	COSMIC	NP	NP
13	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000394532	c.243G>A	p.E81E	COSMIC	NP	NP
14	TCGA-D1-A17R-01	Tumour	ENDOMETRIUM	ENST00000394532	c.298G>A	p.A100T	COSMIC	NP	NP
15	A2058	Cell Line	SKIN	ENST00000394532	c.102C>T	p.S34S	COSMIC	NP	NP
16	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.385C>T	p.L129F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
17	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.410C>A	p.T137K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
18	GP5D	Cell Line	LARGE_INTESTINE	ENST00000394532	c.483G>T	p.R161S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
19	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.453C>A	p.F151L	COSMIC	PASSENGER/OTHER	BENIGN
20	VMCUB1	Cell Line	URINARY_TRACT	ENST00000394532	c.491C>T	p.S164F	COSMIC	PASSENGER/OTHER	BENIGN
21	WIL2NS	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.427_428insA	p.S144fs*>26	COSMIC	NP	NP
22	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116784	c.410C>A	p.T137K	CCLE	PASSENGER/OTHER	Probably Damaging
23	EBC1	Cell Line	LUNG	NP_116784	c.85G>A	p.D29N	CCLE	PASSENGER/OTHER	Probably Damaging
24	GP2D	Cell Line	LARGE INTESTINE	NP_116784	c.483G>T	p.R161S	CCLE	PASSENGER/OTHER	Possibly Damaging
25	HEC265	Cell Line	ENDOMETRIUM	NP_116784	c.208C>T	p.R70W	CCLE	PASSENGER/OTHER	Probably Damaging
26	JHOM1	Cell Line	OVARY	NP_116784	c.95C>T	p.S32L	CCLE	PASSENGER/OTHER	Benign
27	VMCUB1	Cell Line	URINARY TRACT	NP_116784	c.491C>T	p.S164F	CCLE	PASSENGER/OTHER	Benign
28	587278	Tumour	LARGE INTESTINE	ENST00000394532	c.301C>T	p.P101S	COSMIC	NP	NP
29	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000394532	c.371C>T	p.S124F	COSMIC	NP	NP
30	ESO-539	Tumour	OESOPHAGUS	ENST00000394532	c.379-4C>T	p.?	COSMIC	NP	NP
31	LUAD-YINHD	Tumour	LUNG	ENST00000394532	c.450C>G	p.V150V	COSMIC	NP	NP
32	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000394532	c.306delC	p.N103fs*15	COSMIC	NP	NP
33	TCGA-AO-A03U-01	Tumour	BREAST	ENST00000394532	c.288C>T	p.R96R	COSMIC	NP	NP
34	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000394532	c.243G>A	p.E81E	COSMIC	NP	NP
35	TCGA-D1-A17R-01	Tumour	ENDOMETRIUM	ENST00000394532	c.298G>A	p.A100T	COSMIC	NP	NP
36	A2058	Cell Line	SKIN	ENST00000394532	c.102C>T	p.S34S	COSMIC	NP	NP
37	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.385C>T	p.L129F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
38	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.410C>A	p.T137K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	GP5D	Cell Line	LARGE_INTESTINE	ENST00000394532	c.483G>T	p.R161S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
40	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.453C>A	p.F151L	COSMIC	PASSENGER/OTHER	BENIGN
41	VMCUB1	Cell Line	URINARY_TRACT	ENST00000394532	c.491C>T	p.S164F	COSMIC	PASSENGER/OTHER	BENIGN
42	WIL2NS	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000394532	c.427_428insA	p.S144fs*>26	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.0166	6.8539	-0.0433	-0.05465
BILIARY TRACT	6.9254	7.0312	0.1033	0.0395
BONE	7.5503	7.5986	0.0545	-0.002568
BREAST	7.6416	7.57705	0.0749	0.06745
CENTRAL NERVOUS SYSTEM	7.7032	7.8199	-0.0155	-0.024
ENDOMETRIUM	7.1822	7.3069	-0.0007	-0.004906
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.7499	6.7774	0.0252	0.0025
KIDNEY	7.3673	7.4883	-0.0582	0.0515
LARGE INTESTINE	6.8302	6.82435	-0.0024	0.01055
LIVER	7.0967	7.2398	0.0152	0.0217
LUNG	7.4376	7.51965	0.0924	0.11685
OESOPHAGUS	7.3452	7.30745	0.1667	0.18635
OVARY	7.5270	7.4864	0.1739	0.09036
PANCREAS	7.3985	7.4312	0.1981	0.2363
PLEURA	8.0548	8.1639	-0.0044	-0.09416
PROSTATE	7.9950	8.09455	0.0940	0.0470778
SALIVARY GLAND	7.3127	7.3127	0.5219	0.5219
SKIN	7.0379	7.14	-0.1081	-0.01235
SMALL INTESTINE	6.9004	6.9004	0.0222	0.0222
SOFT TISSUE	7.1890	7.40245	0.0092	0.01365
STOMACH	7.3403	7.2841	0.1500	0.15655
THYROID	7.3676	7.5872	0.1312	0.18965
UPPER AERODIGESTIVE TRACT	7.6370	7.74945	0.2988	0.30435
URINARY TRACT	7.7824	7.84425	0.1636	0.26805

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1G5J

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF10514	Bcl-2_BAD	1	168	6.3e-93
PF08945	Bclx_interact	101	125	0.003
PF10514	Bcl-2_BAD	1	168	6.3e-93
PF08945	Bclx_interact	101	125	0.003

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	118	S	Phosphorylation	Phosphoserine
2	118	S	Phosphorylation	Phosphoserine (RSK-1)
3	118	S	Phosphorylation (AKT1)	Phosphoserine
4	118	S	Phosphorylation (PAK1)	Phosphoserine
5	118	S	Phosphorylation (PIM1)	Phosphoserine
6	118	S	Phosphorylation (PIM2)	Phosphoserine
7	118	S	Phosphorylation (PIM3)	Phosphoserine
8	118	S	Phosphorylation (PRKACA)	Phosphoserine
9	118	S	Phosphorylation (RPS6KA1)	Phosphoserine
10	118	S	Phosphorylation (RPS6KA2)	Phosphoserine
11	124	S	Phosphorylation	Phosphoserine
12	134	S	Phosphorylation	Phosphoserine
13	134	S	Phosphorylation (PAK1)	Phosphoserine
14	137	T	Phosphorylation	Phosphothreonine
15	146	S	Phosphorylation	Phosphoserine
16	153	S	Phosphorylation	Phosphoserine
17	153	S	Phosphorylation (PRKACA)	Phosphoserine
18	153	S	Phosphorylation (RPS6KA1)	Phosphoserine
19	153	S	Phosphorylation (RPS6KA5)	Phosphoserine
20	25	S	Phosphorylation	Phosphoserine
21	25	S	Phosphorylation	Phosphoserine.
22	32	S	Phosphorylation	Phosphoserine
23	34	S	Phosphorylation	Phosphoserine
24	36	K	Acetylation	N6-acetyllysine
25	36	K	Acetylation	N6-acetyllysine.
26	71	S	Phosphorylation	Phosphoserine
27	74	S	Phosphorylation	Phosphoserine
28	75	S	Dephosphorylation	DePhosphoserine
29	75	S	Phosphorylation	Phosphoserine
30	75	S	Phosphorylation	Phosphoserine (PKA_group;RSK_group;RSK-2;RSK-1)
31	75	S	Phosphorylation	Phosphoserine; by PKA, PKB, PIM2, PIM3,PAK1, PAK2, PAK4, PAK7/PAK5, RPS6KA1 and
32	75	S	Phosphorylation (AKT1)	Phosphoserine
33	75	S	Phosphorylation (PAK7)	Phosphoserine
34	75	S	Phosphorylation (PIM1)	Phosphoserine
35	75	S	Phosphorylation (PIM2)	Phosphoserine
36	75	S	Phosphorylation (PIM3)	Phosphoserine
37	75	S	Phosphorylation (RPS6KA1)	Phosphoserine
38	75	S	Phosphorylation (RPS6KA2)	Phosphoserine
39	76	Y	Phosphorylation	Phosphotyrosine
40	80	T	Phosphorylation	Phosphothreonine
41	91	S	Phosphorylation	Phosphoserine
42	91	S	Phosphorylation	Phosphoserine.
43	97	S	Phosphorylation	Phosphoserine
44	99	S	Dephosphorylation	DePhosphoserine
45	99	S	Phosphorylation	Phosphoserine
46	99	S	Phosphorylation	Phosphoserine (PKB_group;RSK_group;PAK1)
47	99	S	Phosphorylation	Phosphoserine; by PKA, PKB, PAK1,RPS6KA1, RPS6KB1 and PKC/PRKCQ (By
48	99	S	Phosphorylation	Phosphoserine; by PKB/AKT1.
49	99	S	Phosphorylation (AKT1)	Phosphoserine
50	99	S	Phosphorylation (PIM1)	Phosphoserine
51	99	S	Phosphorylation (PIM2)	Phosphoserine
52	99	S	Phosphorylation (PIM3)	Phosphoserine
53	118	S	Phosphorylation	Phosphoserine
54	118	S	Phosphorylation	Phosphoserine (RSK-1)
55	118	S	Phosphorylation (AKT1)	Phosphoserine
56	118	S	Phosphorylation (PAK1)	Phosphoserine
57	118	S	Phosphorylation (PIM1)	Phosphoserine
58	118	S	Phosphorylation (PIM2)	Phosphoserine
59	118	S	Phosphorylation (PIM3)	Phosphoserine
60	118	S	Phosphorylation (PRKACA)	Phosphoserine
61	118	S	Phosphorylation (RPS6KA1)	Phosphoserine
62	118	S	Phosphorylation (RPS6KA2)	Phosphoserine
63	124	S	Phosphorylation	Phosphoserine
64	134	S	Phosphorylation	Phosphoserine
65	134	S	Phosphorylation (PAK1)	Phosphoserine
66	137	T	Phosphorylation	Phosphothreonine
67	146	S	Phosphorylation	Phosphoserine
68	153	S	Phosphorylation	Phosphoserine
69	153	S	Phosphorylation (PRKACA)	Phosphoserine
70	153	S	Phosphorylation (RPS6KA1)	Phosphoserine
71	153	S	Phosphorylation (RPS6KA5)	Phosphoserine
72	25	S	Phosphorylation	Phosphoserine
73	25	S	Phosphorylation	Phosphoserine.
74	32	S	Phosphorylation	Phosphoserine
75	34	S	Phosphorylation	Phosphoserine
76	36	K	Acetylation	N6-acetyllysine
77	36	K	Acetylation	N6-acetyllysine.
78	71	S	Phosphorylation	Phosphoserine
79	74	S	Phosphorylation	Phosphoserine
80	75	S	Dephosphorylation	DePhosphoserine
81	75	S	Phosphorylation	Phosphoserine
82	75	S	Phosphorylation	Phosphoserine (PKA_group;RSK_group;RSK-2;RSK-1)
83	75	S	Phosphorylation	Phosphoserine; by PKA, PKB, PIM2, PIM3,PAK1, PAK2, PAK4, PAK7/PAK5, RPS6KA1 and
84	75	S	Phosphorylation (AKT1)	Phosphoserine
85	75	S	Phosphorylation (PAK7)	Phosphoserine
86	75	S	Phosphorylation (PIM1)	Phosphoserine
87	75	S	Phosphorylation (PIM2)	Phosphoserine
88	75	S	Phosphorylation (PIM3)	Phosphoserine
89	75	S	Phosphorylation (RPS6KA1)	Phosphoserine
90	75	S	Phosphorylation (RPS6KA2)	Phosphoserine
91	76	Y	Phosphorylation	Phosphotyrosine
92	80	T	Phosphorylation	Phosphothreonine
93	91	S	Phosphorylation	Phosphoserine
94	91	S	Phosphorylation	Phosphoserine.
95	97	S	Phosphorylation	Phosphoserine
96	99	S	Dephosphorylation	DePhosphoserine
97	99	S	Phosphorylation	Phosphoserine
98	99	S	Phosphorylation	Phosphoserine (PKB_group;RSK_group;PAK1)
99	99	S	Phosphorylation	Phosphoserine; by PKA, PKB, PAK1,RPS6KA1, RPS6KB1 and PKC/PRKCQ (By
100	99	S	Phosphorylation	Phosphoserine; by PKB/AKT1.
101	99	S	Phosphorylation (AKT1)	Phosphoserine
102	99	S	Phosphorylation (PIM1)	Phosphoserine
103	99	S	Phosphorylation (PIM2)	Phosphoserine
104	99	S	Phosphorylation (PIM3)	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BAD	BAD	BAD	ENSP00000309103	Q92934
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q92934	BAD	ENSP00000309103	BAD	Q92934
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BAD	ENSP00000309103	603167	Q92934	PA25236

Protein: BAD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)