ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587238	Tumour	LARGE INTESTINE	ENST00000306730	c.433C>A	p.L145I	COSMIC	NP	NP
2	587376	Tumour	LARGE INTESTINE	ENST00000306730	c.395G>T	p.S132I	COSMIC	NP	NP
3	EKVX	Cell Line	LUNG	ENST00000306730	c.887T>A	p.I296K	COSMIC	NP	NP
4	ESO-135	Tumour	OESOPHAGUS	ENST00000306730	c.622C>T	p.P208S	COSMIC	NP	NP
5	GC4	Tumour	T STOMACH	ENST00000306730	c.342delT	p.I114fs*96	COSMIC	NP	NP
6	HCC4T	Tumour	LIVER	ENST00000306730	c.974-8delt	p.?	COSMIC	NP	NP
7	HX13T	Tumour	LIVER	ENST00000306730	c.974-8delt	p.?	COSMIC	NP	NP
8	LB1047-RCC	Cell Line	KIDNEY	ENST00000306730	c.937T>C	p.S313P	COSMIC	NP	NP
9	LUAD-FH5PJ	Tumour	LUNG	ENST00000306730	c.699G>T	p.L233F	COSMIC	NP	NP
10	LUAD-RT-S01777	Tumour	LUNG	ENST00000306730	c.735A>T	p.K245N	COSMIC	NP	NP
11	LUAD-S01381	Tumour	LUNG	ENST00000306730	c.123_134del12	p.G42_G45delGGGG	COSMIC	NP	NP
12	RK021	Tumour	C01 LIVER	ENST00000306730	c.852A>G	p.E284E	COSMIC	NP	NP
13	SWE-4A	Tumour	PROSTATE	ENST00000306730	c.997G>A	p.E333K	COSMIC	NP	NP
14	TCGA-18-3409-01	Tumour	LUNG	ENST00000306730	c.800A>C	p.D267A	COSMIC	NP	NP
15	TCGA-64-5815-01	Tumour	LUNG	ENST00000306730	c.382G>T	p.V128F	COSMIC	NP	NP
16	TCGA-78-7159-01	Tumour	LUNG	ENST00000306730	c.430C>A	p.L144I	COSMIC	NP	NP
17	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000306730	c.310G>T	p.D104Y	COSMIC	NP	NP
18	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000306730	c.359G>A	p.R120Q	COSMIC	NP	NP
19	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000306730	c.418G>T	p.D140Y	COSMIC	NP	NP
20	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000306730	c.938C>A	p.S313Y	COSMIC	NP	NP
21	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000306730	c.339G>T	p.K113N	COSMIC	NP	NP
22	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000306730	c.601G>A	p.E201K	COSMIC	NP	NP
23	TCGA-B5-A11J-01	Tumour	ENDOMETRIUM	ENST00000306730	c.962A>G	p.Q321R	COSMIC	NP	NP
24	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000306730	c.306G>T	p.E102D	COSMIC	NP	NP
25	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000306730	c.1008C>G	p.N336K	COSMIC	NP	NP
26	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000306730	c.1047C>A	p.T349T	COSMIC	NP	NP
27	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000306730	c.517-1G>A	p.?	COSMIC	NP	NP
28	TCGA-DS-A0VM-01	Tumour	CERVIX	ENST00000306730	c.932T>C	p.L311P	COSMIC	NP	NP
29	WA49	Tumour	PROSTATE	ENST00000306730	c.920C>T	p.T307M	COSMIC	NP	NP
30	ccRCC-77	Tumour	KIDNEY	ENST00000306730	c.419delA	p.D140fs*70	COSMIC	NP	NP
31	C33A	Cell Line	CERVIX	ENST00000306730	c.1007delA	p.N336fs*25	COSMIC	NP	NP
32	CCK81	Cell Line	LARGE_INTESTINE	ENST00000306730	c.974-7C>T	p.?	COSMIC	NP	NP
33	CMLT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000306730	c.1049A>T	p.E350V	COSMIC	CANCER	PROBABLY DAMAGING
34	COLO668	Cell Line	LUNG	ENST00000306730	c.678G>T	p.G226G	COSMIC	NP	NP
35	CW2	Cell Line	LARGE_INTESTINE	ENST00000306730	c.807G>T	p.Q269H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
36	CW2	Cell Line	LARGE_INTESTINE	ENST00000306730	c.835G>A	p.G279R	COSMIC	PASSENGER/OTHER	BENIGN
37	DU145	Cell Line	PROSTATE	ENST00000306730	c.973+5G>A	p.?	COSMIC	NP	NP
38	EKVX	Cell Line	LUNG	ENST00000306730	c.887T>A	p.I296K	COSMIC	PASSENGER/OTHER	BENIGN
39	EN	Cell Line	ENDOMETRIUM	ENST00000306730	c.1052A>G	p.E351G	COSMIC	CANCER	PROBABLY DAMAGING
40	HCC202	Cell Line	BREAST	ENST00000306730	c.530A>G	p.Y177C	COSMIC	PASSENGER/OTHER	BENIGN
41	HCC78	Cell Line	LUNG	ENST00000306730	c.757G>T	p.V253L	COSMIC	PASSENGER/OTHER	BENIGN
42	KYSE180	Cell Line	OESOPHAGUS	ENST00000306730	c.574C>G	p.L192V	COSMIC	CANCER	PROBABLY DAMAGING
43	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000306730	c.974-7C>T	p.?	COSMIC	NP	NP
44	MC116	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000306730	c.894G>A	p.E298E	COSMIC	NP	NP
45	ME180	Cell Line	CERVIX	ENST00000306730	c.377_378delAA	p.K126fs*4	COSMIC	NP	NP
46	MRKNU1	Cell Line	BREAST	ENST00000306730	c.871A>C	p.N291H	COSMIC	PASSENGER/OTHER	BENIGN
47	NCIH1770	Cell Line	LUNG	ENST00000306730	c.446-5C>T	p.?	COSMIC	NP	NP
48	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000306730	c.286G>A	p.A96T	COSMIC	PASSENGER/OTHER	BENIGN
49	SKMEL5	Cell Line	SKIN	ENST00000306730	c.446-5C>T	p.?	COSMIC	NP	NP
50	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000306730	c.490G>A	p.D164N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
51	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000306730	c.785C>T	p.P262L	COSMIC	PASSENGER/OTHER	BENIGN
52	TE4	Cell Line	OESOPHAGUS	ENST00000306730	c.678G>A	p.G226G	COSMIC	NP	NP
53	TGBC11TKB	Cell Line	STOMACH	ENST00000306730	c.1007delA	p.N336fs*25	COSMIC	NP	NP
54	TK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000306730	c.613-7C>T	p.?	COSMIC	NP	NP
55	587238	Tumour	LARGE INTESTINE	ENST00000306730	c.433C>A	p.L145I	COSMIC	NP	NP
56	587376	Tumour	LARGE INTESTINE	ENST00000306730	c.395G>T	p.S132I	COSMIC	NP	NP
57	EKVX	Cell Line	LUNG	ENST00000306730	c.887T>A	p.I296K	COSMIC	NP	NP
58	ESO-135	Tumour	OESOPHAGUS	ENST00000306730	c.622C>T	p.P208S	COSMIC	NP	NP
59	GC4	Tumour	T STOMACH	ENST00000306730	c.342delT	p.I114fs*96	COSMIC	NP	NP
60	HCC4T	Tumour	LIVER	ENST00000306730	c.974-8delt	p.?	COSMIC	NP	NP
61	HX13T	Tumour	LIVER	ENST00000306730	c.974-8delt	p.?	COSMIC	NP	NP
62	LB1047-RCC	Cell Line	KIDNEY	ENST00000306730	c.937T>C	p.S313P	COSMIC	NP	NP
63	LUAD-FH5PJ	Tumour	LUNG	ENST00000306730	c.699G>T	p.L233F	COSMIC	NP	NP
64	LUAD-RT-S01777	Tumour	LUNG	ENST00000306730	c.735A>T	p.K245N	COSMIC	NP	NP
65	LUAD-S01381	Tumour	LUNG	ENST00000306730	c.123_134del12	p.G42_G45delGGGG	COSMIC	NP	NP
66	RK021	Tumour	C01 LIVER	ENST00000306730	c.852A>G	p.E284E	COSMIC	NP	NP
67	SWE-4A	Tumour	PROSTATE	ENST00000306730	c.997G>A	p.E333K	COSMIC	NP	NP
68	TCGA-18-3409-01	Tumour	LUNG	ENST00000306730	c.800A>C	p.D267A	COSMIC	NP	NP
69	TCGA-64-5815-01	Tumour	LUNG	ENST00000306730	c.382G>T	p.V128F	COSMIC	NP	NP
70	TCGA-78-7159-01	Tumour	LUNG	ENST00000306730	c.430C>A	p.L144I	COSMIC	NP	NP
71	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000306730	c.310G>T	p.D104Y	COSMIC	NP	NP
72	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000306730	c.359G>A	p.R120Q	COSMIC	NP	NP
73	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000306730	c.418G>T	p.D140Y	COSMIC	NP	NP
74	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000306730	c.938C>A	p.S313Y	COSMIC	NP	NP
75	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000306730	c.339G>T	p.K113N	COSMIC	NP	NP
76	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000306730	c.601G>A	p.E201K	COSMIC	NP	NP
77	TCGA-B5-A11J-01	Tumour	ENDOMETRIUM	ENST00000306730	c.962A>G	p.Q321R	COSMIC	NP	NP
78	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000306730	c.306G>T	p.E102D	COSMIC	NP	NP
79	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000306730	c.1008C>G	p.N336K	COSMIC	NP	NP
80	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000306730	c.1047C>A	p.T349T	COSMIC	NP	NP
81	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000306730	c.517-1G>A	p.?	COSMIC	NP	NP
82	TCGA-DS-A0VM-01	Tumour	CERVIX	ENST00000306730	c.932T>C	p.L311P	COSMIC	NP	NP
83	WA49	Tumour	PROSTATE	ENST00000306730	c.920C>T	p.T307M	COSMIC	NP	NP
84	ccRCC-77	Tumour	KIDNEY	ENST00000306730	c.419delA	p.D140fs*70	COSMIC	NP	NP
85	C33A	Cell Line	CERVIX	ENST00000306730	c.1007delA	p.N336fs*25	COSMIC	NP	NP
86	CCK81	Cell Line	LARGE_INTESTINE	ENST00000306730	c.974-7C>T	p.?	COSMIC	NP	NP
87	CMLT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000306730	c.1049A>T	p.E350V	COSMIC	CANCER	PROBABLY DAMAGING
88	COLO668	Cell Line	LUNG	ENST00000306730	c.678G>T	p.G226G	COSMIC	NP	NP
89	CW2	Cell Line	LARGE_INTESTINE	ENST00000306730	c.807G>T	p.Q269H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
90	CW2	Cell Line	LARGE_INTESTINE	ENST00000306730	c.835G>A	p.G279R	COSMIC	PASSENGER/OTHER	BENIGN
91	DU145	Cell Line	PROSTATE	ENST00000306730	c.973+5G>A	p.?	COSMIC	NP	NP
92	EKVX	Cell Line	LUNG	ENST00000306730	c.887T>A	p.I296K	COSMIC	PASSENGER/OTHER	BENIGN
93	EN	Cell Line	ENDOMETRIUM	ENST00000306730	c.1052A>G	p.E351G	COSMIC	CANCER	PROBABLY DAMAGING
94	HCC202	Cell Line	BREAST	ENST00000306730	c.530A>G	p.Y177C	COSMIC	PASSENGER/OTHER	BENIGN
95	HCC78	Cell Line	LUNG	ENST00000306730	c.757G>T	p.V253L	COSMIC	PASSENGER/OTHER	BENIGN
96	KYSE180	Cell Line	OESOPHAGUS	ENST00000306730	c.574C>G	p.L192V	COSMIC	CANCER	PROBABLY DAMAGING
97	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000306730	c.974-7C>T	p.?	COSMIC	NP	NP
98	MC116	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000306730	c.894G>A	p.E298E	COSMIC	NP	NP
99	ME180	Cell Line	CERVIX	ENST00000306730	c.377_378delAA	p.K126fs*4	COSMIC	NP	NP
100	MRKNU1	Cell Line	BREAST	ENST00000306730	c.871A>C	p.N291H	COSMIC	PASSENGER/OTHER	BENIGN
101	NCIH1770	Cell Line	LUNG	ENST00000306730	c.446-5C>T	p.?	COSMIC	NP	NP
102	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000306730	c.286G>A	p.A96T	COSMIC	PASSENGER/OTHER	BENIGN
103	SKMEL5	Cell Line	SKIN	ENST00000306730	c.446-5C>T	p.?	COSMIC	NP	NP
104	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000306730	c.490G>A	p.D164N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
105	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000306730	c.785C>T	p.P262L	COSMIC	PASSENGER/OTHER	BENIGN
106	TE4	Cell Line	OESOPHAGUS	ENST00000306730	c.678G>A	p.G226G	COSMIC	NP	NP
107	TGBC11TKB	Cell Line	STOMACH	ENST00000306730	c.1007delA	p.N336fs*25	COSMIC	NP	NP
108	TK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000306730	c.613-7C>T	p.?	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	8.2594	8.3102	0.0582	0.0446
BILIARY TRACT	8.5607	8.5151	-0.1208	-0.0435
BONE	9.1654	9.4244	0.0204	0.002
BREAST	8.3943	8.3875	-0.1406	-0.11345
CENTRAL NERVOUS SYSTEM	8.9414	8.9773	0.0311	0.05242
ENDOMETRIUM	8.0385	8.0603	-0.1640	-0.07341
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.7776	8.8692	-0.0041	0.0073
KIDNEY	8.7128	8.6546	-0.0767	0.002029
LARGE INTESTINE	8.7775	8.76945	-0.0090	-0.0049
LIVER	8.5330	8.5648	-0.0737	-0.1475
LUNG	8.1864	8.31245	-0.1174	-0.07787
OESOPHAGUS	8.4555	8.40755	-0.1059	-0.10095
OVARY	8.3500	8.3151	-0.1020	-0.0319
PANCREAS	8.5164	8.6155	-0.0575	0.02237
PLEURA	9.3072	9.4739	-0.0191	-0.02034
PROSTATE	7.8061	8.0533	-0.0673	0.03256
SALIVARY GLAND	8.2025	8.2025	-0.1859	-0.1859
SKIN	8.3919	8.3636	-0.0342	0.0172
SMALL INTESTINE	7.7521	7.7521	0.0315	0.03148
SOFT TISSUE	8.6785	8.83815	0.0784	0.01385
STOMACH	8.3550	8.3328	-0.0754	-0.1092
THYROID	9.0421	8.97955	0.0677	0.07285
UPPER AERODIGESTIVE TRACT	8.2820	8.31175	0.0284	0.0448
URINARY TRACT	8.7407	8.7231	-0.0158	-0.010558

Domain ID	Domain Name	Start Site	End Site	E-value
PF07340	Herpes_IE1	257	317	0.064
PF07340	Herpes_IE1	257	317	0.064

S. No.	Position	Amino acid	Type	Description
1	135	S	Phosphorylation	Phosphoserine
2	215	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
3	261	S	Phosphorylation	Phosphoserine
4	273	S	Phosphorylation	Phosphoserine
5	308	S	Phosphorylation	Phosphoserine
6	94	S	Phosphorylation	Phosphoserine
7	94	S	Phosphorylation	Phosphoserine.
8	98	T	Phosphorylation	Phosphothreonine
9	99	Y	Phosphorylation	Phosphotyrosine
10	135	S	Phosphorylation	Phosphoserine
11	215	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	261	S	Phosphorylation	Phosphoserine
13	273	S	Phosphorylation	Phosphoserine
14	308	S	Phosphorylation	Phosphoserine
15	94	S	Phosphorylation	Phosphoserine
16	94	S	Phosphorylation	Phosphoserine.
17	98	T	Phosphorylation	Phosphothreonine
18	99	Y	Phosphorylation	Phosphotyrosine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
AVEN	AVEN	AVEN	ENSP00000306822	Q9NQS1
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9NQS1	AVEN	ENSP00000306822	AVEN	Q9NQS1
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
AVEN	ENSP00000306822	605265	Q9NQS1	PA134874337

Protein: AVEN

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB