ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	639V	Cell Line	URINARY TRACT	NP_863651	c.803_804delGT	p.S268fs	CCLE	NP	NP
2	A498	Cell Line	KIDNEY	NP_863651	c.1474G>A	p.A492T	CCLE	PASSENGER/OTHER	Probably Damaging
3	AGS	Cell Line	STOMACH	NP_863651	c.3457A>G	p.I1153V	CCLE	PASSENGER/OTHER	Benign
4	BICR56	Cell Line	UPPER AERODIGESTIVE TRACT	NP_863651	c.1783C>G	p.L595V	CCLE	PASSENGER/OTHER	Benign
5	CL34	Cell Line	LARGE INTESTINE	NP_863651	c.697C>T	p.R233C	CCLE	PASSENGER/OTHER	Benign
6	CORL47	Cell Line	LUNG	NP_863651	c.38G>C	p.R13T	CCLE	PASSENGER/OTHER	Possibly Damaging
7	CW2	Cell Line	LARGE INTESTINE	NP_863651	c.1746G>A	p.L582L	CCLE	NP	NP
8	CW2	Cell Line	LARGE INTESTINE	NP_863651	c.614G>A	p.R205Q	CCLE	PASSENGER/OTHER	Probably Damaging
9	DMS53	Cell Line	LUNG	NP_863651	c.2947G>A	p.G983R	CCLE	PASSENGER/OTHER	Probably Damaging
10	EN	Cell Line	ENDOMETRIUM	NP_863651	c.3391C>T	p.R1131C	CCLE	PASSENGER/OTHER	Probably Damaging
11	HCC202	Cell Line	BREAST	NP_863651	c.1357C>T	p.L453F	CCLE	PASSENGER/OTHER	Probably Damaging
12	HCC366	Cell Line	LUNG	NP_863651	c.1201T>C	p.C401R	CCLE	PASSENGER/OTHER	Probably Damaging
13	HEC108	Cell Line	ENDOMETRIUM	NP_863651	c.1798_1798delA	p.K600fs	CCLE	NP	NP
14	HEC1B	Cell Line	ENDOMETRIUM	NP_863651	c.2023T>C	p.C675R	CCLE	PASSENGER/OTHER	Probably Damaging
15	HEC50B	Cell Line	ENDOMETRIUM	NP_863651	c.3527A>C	p.H1176P	CCLE	CANCER	Probably Damaging
16	HRT18	Cell Line	LARGE INTESTINE	NP_863651	c.964C>A	p.L322I	CCLE	PASSENGER/OTHER	Probably Damaging
17	HS698T	Cell Line	LARGE INTESTINE	NP_863651	c.548A>G	p.H183R	CCLE	PASSENGER/OTHER	Probably Damaging
18	IM95	Cell Line	STOMACH	NP_863651	c.1823G>A	p.R608H	CCLE	PASSENGER/OTHER	Possibly Damaging
19	IM95	Cell Line	STOMACH	NP_863651	c.3263T>C	p.V1088A	CCLE	PASSENGER/OTHER	Possibly Damaging
20	JHH7	Cell Line	LIVER	NP_863651	c.181C>G	p.L61V	CCLE	PASSENGER/OTHER	Probably Damaging
21	KCL22	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_863651	c.1655G>A	p.G552E	CCLE	PASSENGER/OTHER	Probably Damaging
22	L363	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_863651	c.3001C>G	p.Q1001E	CCLE	PASSENGER/OTHER	Benign
23	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_863651	c.1797_1798insA	p.N599fs	CCLE	NP	NP
24	LOVO	Cell Line	LARGE INTESTINE	NP_863651	c.2120T>C	p.F707S	CCLE	PASSENGER/OTHER	Probably Damaging
25	LS411N	Cell Line	LARGE INTESTINE	NP_863651	c.676C>A	p.R226S	CCLE	PASSENGER/OTHER	Probably Damaging
26	MFE319	Cell Line	ENDOMETRIUM	NP_863651	c.1797_1798insA	p.N599fs	CCLE	NP	NP
27	NCIH1339	Cell Line	LUNG	NP_863651	c.2207G>A	p.R736Q	CCLE	PASSENGER/OTHER	Possibly Damaging
28	NCIH1385	Cell Line	LUNG	NP_863651	c.3388G>T	p.V1130L	CCLE	PASSENGER/OTHER	Probably Damaging
29	NCIH1666	Cell Line	LUNG	NP_863651	c.2825A>T	p.H942L	CCLE	PASSENGER/OTHER	Benign
30	SNU81	Cell Line	LARGE INTESTINE	NP_863651	c.217A>G	p.N73D	CCLE	PASSENGER/OTHER	Possibly Damaging
31	SNUC2A	Cell Line	LARGE INTESTINE	NP_863651	c.239A>T	p.Y80F	CCLE	PASSENGER/OTHER	Probably Damaging
32	YD38	Cell Line	UPPER AERODIGESTIVE TRACT	NP_863651	c.3740T>C	p.L1247S	CCLE	PASSENGER/OTHER	Possibly Damaging
33	09-044	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000551964	c.1431G>T	p.Q477H	COSMIC	NP	NP
34	585267	Tumour	LUNG	ENST00000551964	c.793A>G	p.R265G	COSMIC	NP	NP
35	587222	Tumour	LARGE INTESTINE	ENST00000551964	c.2773G>T	p.E925*	COSMIC	NP	NP
36	587224	Tumour	LARGE INTESTINE	ENST00000551964	c.2474A>C	p.D825A	COSMIC	NP	NP
37	587290	Tumour	LARGE INTESTINE	ENST00000551964	c.418C>T	p.L140F	COSMIC	NP	NP
38	587376	Tumour	LARGE INTESTINE	ENST00000551964	c.2329G>T	p.E777*	COSMIC	NP	NP
39	CLL063	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000551964	c.1840C>G	p.H614D	COSMIC	NP	NP
40	CRC-9	Tumour	LARGE INTESTINE	ENST00000551964	c.1712C>T	p.P571L	COSMIC	NP	NP
41	H1155	Cell Line	LUNG	ENST00000551964	c.2114G>A	p.C705Y	COSMIC	NP	NP
42	H2009	Cell Line	LUNG	ENST00000551964	c.392A>T	p.K131M	COSMIC	NP	NP
43	HCC139T	Tumour	LIVER	ENST00000551964	c.3127C>T	p.H1043Y	COSMIC	NP	NP
44	HCC17T	Tumour	LIVER	ENST00000551964	c.2156G>A	p.G719E	COSMIC	NP	NP
45	HCC2998	Cell Line	LARGE INTESTINE	ENST00000551964	c.3224G>A	p.G1075E	COSMIC	NP	NP
46	HCC6T	Tumour	LIVER	ENST00000551964	c.3135A>T	p.E1045D	COSMIC	NP	NP
47	LUAD-5V8LT	Tumour	LUNG	ENST00000551964	c.1062G>T	p.R354S	COSMIC	NP	NP
48	ME002T	Tumour	SKIN	ENST00000551964	c.3601T>C	p.W1201R	COSMIC	NP	NP
49	MI2	Tumour	LARGE INTESTINE	ENST00000551964	c.2651G>A	p.W884*	COSMIC	NP	NP
50	NCI-H2009	Cell Line	LUNG	ENST00000551964	c.392A>T	p.K131M	COSMIC	NP	NP
51	P56	Tumour	LIVER	ENST00000551964	c.153A>T	p.Q51H	COSMIC	NP	NP
52	PD6763a	Tumour	NS	ENST00000551964	c.1754A>G	p.K585R	COSMIC	NP	NP
53	RK046	Tumour	C01 LIVER	ENST00000551964	c.2248A>G	p.R750G	COSMIC	NP	NP
54	RK126	Tumour	C01 LIVER	ENST00000551964	c.2954T>G	p.I985S	COSMIC	NP	NP
55	RK159	Tumour	C01 LIVER	ENST00000551964	c.1406A>G	p.Q469R	COSMIC	NP	NP
56	S00827	Tumour	LUNG	ENST00000551964	c.1396A>T	p.R466*	COSMIC	NP	NP
57	TARGET-30-PASXGP	Tumour	AUTONOMIC GANGLIA	ENST00000551964	c.1879G>C	p.G627R	COSMIC	NP	NP
58	TCGA-05-4432-01	Tumour	LUNG	ENST00000551964	c.2014A>G	p.I672V	COSMIC	NP	NP
59	TCGA-09-1665-01	Tumour	OVARY	ENST00000551964	c.1435G>A	p.D479N	COSMIC	NP	NP
60	TCGA-13-0923-01	Tumour	OVARY	ENST00000551964	c.437A>T	p.E146V	COSMIC	NP	NP
61	TCGA-22-4613-01	Tumour	LUNG	ENST00000551964	c.236G>T	p.G79V	COSMIC	NP	NP
62	TCGA-38-4625-01	Tumour	LUNG	ENST00000551964	c.2485A>T	p.S829C	COSMIC	NP	NP
63	TCGA-39-5022-01	Tumour	LUNG	ENST00000551964	c.2135A>G	p.H712R	COSMIC	NP	NP
64	TCGA-50-5044-01	Tumour	LUNG	ENST00000551964	c.771G>A	p.Q257Q	COSMIC	NP	NP
65	TCGA-55-6985-01	Tumour	LUNG	ENST00000551964	c.2829A>T	p.I943I	COSMIC	NP	NP
66	TCGA-55-7914-01	Tumour	LUNG	ENST00000551964	c.149A>T	p.Q50L	COSMIC	NP	NP
67	TCGA-66-2766-01	Tumour	LUNG	ENST00000551964	c.945A>T	p.K315N	COSMIC	NP	NP
68	TCGA-66-2788-01	Tumour	LUNG	ENST00000551964	c.1455C>G	p.N485K	COSMIC	NP	NP
69	TCGA-67-4679-01	Tumour	LUNG	ENST00000551964	c.613C>A	p.R205R	COSMIC	NP	NP
70	TCGA-78-7537-01	Tumour	LUNG	ENST00000551964	c.2068G>A	p.E690K	COSMIC	NP	NP
71	TCGA-85-6561-01	Tumour	LUNG	ENST00000551964	c.2115C>T	p.C705C	COSMIC	NP	NP
72	TCGA-95-7944-01	Tumour	LUNG	ENST00000551964	c.3121C>A	p.R1041R	COSMIC	NP	NP
73	TCGA-A5-A0GV-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1387C>T	p.Q463*	COSMIC	NP	NP
74	TCGA-A6-2676-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1812G>A	p.T604T	COSMIC	NP	NP
75	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
76	TCGA-A6-5666-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1436A>G	p.D479G	COSMIC	NP	NP
77	TCGA-AA-3502-01	Tumour	LARGE INTESTINE	ENST00000551964	c.437A>G	p.E146G	COSMIC	NP	NP
78	TCGA-AA-3516-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798_1799delAA	p.N602fs*23	COSMIC	NP	NP
79	TCGA-AA-3548-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1377G>A	p.K459K	COSMIC	NP	NP
80	TCGA-AA-3712-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
81	TCGA-AA-3713-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2615G>A	p.R872H	COSMIC	NP	NP
82	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1655G>A	p.G552E	COSMIC	NP	NP
83	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2510C>T	p.T837M	COSMIC	NP	NP
84	TCGA-AA-3950-01	Tumour	LARGE INTESTINE	ENST00000551964	c.3673G>A	p.V1225M	COSMIC	NP	NP
85	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2339G>T	p.S780I	COSMIC	NP	NP
86	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2595G>A	p.E865E	COSMIC	NP	NP
87	TCGA-AA-3984-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1812G>A	p.T604T	COSMIC	NP	NP
88	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1539A>C	p.K513N	COSMIC	NP	NP
89	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1301G>A	p.R434H	COSMIC	NP	NP
90	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000551964	c.796G>T	p.D266Y	COSMIC	NP	NP
91	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1608+1_1608+2insTA	p.?	COSMIC	NP	NP
92	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1939G>T	p.G647*	COSMIC	NP	NP
93	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2304+2T>C	p.?	COSMIC	NP	NP
94	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1505C>A	p.A502D	COSMIC	NP	NP
95	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1132G>T	p.D378Y	COSMIC	NP	NP
96	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2316G>A	p.A772A	COSMIC	NP	NP
97	TCGA-B0-5098-01	Tumour	KIDNEY	ENST00000551964	c.2658T>C	p.H886H	COSMIC	NP	NP
98	TCGA-B5-A0JR-01	Tumour	ENDOMETRIUM	ENST00000551964	c.3184T>C	p.S1062P	COSMIC	NP	NP
99	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1055G>T	p.R352I	COSMIC	NP	NP
100	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2305-1G>T	p.?	COSMIC	NP	NP
101	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000551964	c.3649G>T	p.G1217*	COSMIC	NP	NP
102	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000551964	c.614G>A	p.R205Q	COSMIC	NP	NP
103	TCGA-BG-A0MS-01	Tumour	ENDOMETRIUM	ENST00000551964	c.682C>T	p.R228C	COSMIC	NP	NP
104	TCGA-BH-A0HP-01	Tumour	BREAST	ENST00000551964	c.247C>T	p.L83F	COSMIC	NP	NP
105	TCGA-BH-A1FC-01	Tumour	BREAST	ENST00000551964	c.1975G>A	p.E659K	COSMIC	NP	NP
106	TCGA-BK-A0C9-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1593T>C	p.H531H	COSMIC	NP	NP
107	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2038A>C	p.K680Q	COSMIC	NP	NP
108	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2794G>T	p.E932*	COSMIC	NP	NP
109	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000551964	c.574A>G	p.K192E	COSMIC	NP	NP
110	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000551964	c.176T>C	p.M59T	COSMIC	NP	NP
111	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000551964	c.508G>T	p.D170Y	COSMIC	NP	NP
112	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000551964	c.3040G>A	p.D1014N	COSMIC	NP	NP
113	TCGA-CJ-5672-01	Tumour	KIDNEY	ENST00000551964	c.3191A>G	p.D1064G	COSMIC	NP	NP
114	TCGA-CK-4947-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
115	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000551964	c.987A>G	p.A329A	COSMIC	NP	NP
116	TCGA-CM-5341-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2365A>T	p.N789Y	COSMIC	NP	NP
117	TCGA-CM-6170-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
118	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2058T>C	p.S686S	COSMIC	NP	NP
119	TCGA-CM-6674-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
120	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1249G>A	p.E417K	COSMIC	NP	NP
121	TCGA-D1-A160-01	Tumour	ENDOMETRIUM	ENST00000551964	c.135T>C	p.N45N	COSMIC	NP	NP
122	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000551964	c.575A>C	p.K192T	COSMIC	NP	NP
123	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2358delC	p.F787fs*2	COSMIC	NP	NP
124	TCGA-D5-5540-01	Tumour	LARGE INTESTINE	ENST00000551964	c.437A>G	p.E146G	COSMIC	NP	NP
125	TCGA-D5-6535-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
126	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1731T>G	p.Y577*	COSMIC	NP	NP
127	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
128	TCGA-DC-6155-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
129	TCGA-DY-A0XA-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
130	TCGA-E9-A1N3-01	Tumour	BREAST	ENST00000551964	c.1997C>G	p.S666C	COSMIC	NP	NP
131	TCGA-EI-6507-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
132	TCGA-EJ-5496-01	Tumour	PROSTATE	ENST00000551964	c.511C>T	p.H171Y	COSMIC	NP	NP
133	TCGA-F4-6703-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
134	TCGA-G2-A2ES-01	Tumour	URINARY TRACT	ENST00000551964	c.3500C>T	p.P1167L	COSMIC	NP	NP
135	TCGA-G4-6299-01	Tumour	LARGE INTESTINE	ENST00000551964	c.436G>A	p.E146K	COSMIC	NP	NP
136	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
137	WA47	Tumour	PROSTATE	ENST00000551964	c.3679C>T	p.P1227S	COSMIC	NP	NP
138	YUDUTY	Tumour	SKIN	ENST00000551964	c.1522G>A	p.D508N	COSMIC	NP	NP
139	YUGOE	Tumour	SKIN	ENST00000551964	c.2021C>T	p.T674I	COSMIC	NP	NP
140	ccRCC-41	Tumour	KIDNEY	ENST00000551964	c.1799A>G	p.K600R	COSMIC	NP	NP
141	ccRCC-75	Tumour	KIDNEY	ENST00000551964	c.1309T>A	p.L437I	COSMIC	NP	NP
142	pfg008T	Tumour	STOMACH	ENST00000551964	c.59T>C	p.I20T	COSMIC	NP	NP
143	pfg019T	Tumour	STOMACH	ENST00000551964	c.139-10delt	p.?	COSMIC	NP	NP
144	22RV1	Cell Line	PROSTATE	ENST00000551964	c.205G>A	p.V69I	COSMIC	PASSENGER/OTHER	BENIGN
145	A498	Cell Line	KIDNEY	ENST00000551964	c.1474G>A	p.A492T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
146	AGS	Cell Line	STOMACH	ENST00000551964	c.3457A>G	p.I1153V	COSMIC	PASSENGER/OTHER	BENIGN
147	BFTC905	Cell Line	URINARY_TRACT	ENST00000551964	c.2274G>A	p.L758L	COSMIC	NP	NP
148	CA922	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000551964	c.697C>T	p.R233C	COSMIC	PASSENGER/OTHER	BENIGN
149	CCRFCEM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3286G>A	p.D1096N	COSMIC	PASSENGER/OTHER	BENIGN
150	CCRFCEM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3412G>A	p.D1138N	COSMIC	PASSENGER/OTHER	BENIGN
151	CL34	Cell Line	LARGE_INTESTINE	ENST00000551964	c.697C>T	p.R233C	COSMIC	PASSENGER/OTHER	BENIGN
152	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
153	CW2	Cell Line	LARGE_INTESTINE	ENST00000551964	c.201C>G	p.S67S	COSMIC	NP	NP
154	CW2	Cell Line	LARGE_INTESTINE	ENST00000551964	c.614G>A	p.R205Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
155	DMS53	Cell Line	LUNG	ENST00000551964	c.2947G>A	p.G983R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
156	EN	Cell Line	ENDOMETRIUM	ENST00000551964	c.3391C>T	p.R1131C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
157	GP5D	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-8T>A	p.?	COSMIC	NP	NP
158	H2810	Cell Line	PLEURA	ENST00000551964	c.3007A>G	p.K1003E	COSMIC	PASSENGER/OTHER	BENIGN
159	H2818	Cell Line	PLEURA	ENST00000551964	c.3457-7T>C	p.?	COSMIC	NP	NP
160	HCC202	Cell Line	BREAST	ENST00000551964	c.1357C>T	p.L453F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
161	HCC2218	Cell Line	BREAST	ENST00000551964	c.2875C>T	p.L959L	COSMIC	NP	NP
162	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000551964	c.177G>T	p.M59I	COSMIC	PASSENGER/OTHER	BENIGN
163	HCC366	Cell Line	LUNG	ENST00000551964	c.1201T>C	p.C401R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
164	IM95	Cell Line	STOMACH	ENST00000551964	c.1823G>A	p.R608H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
165	IM95	Cell Line	STOMACH	ENST00000551964	c.3263T>C	p.V1088A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
166	JHH7	Cell Line	LIVER	ENST00000551964	c.181C>G	p.L61V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
167	JHOS4	Cell Line	OVARY	ENST00000551964	c.134A>G	p.N45S	COSMIC	PASSENGER/OTHER	BENIGN
168	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1655G>A	p.G552E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
169	KMH2	Cell Line	THYROID	ENST00000551964	c.134A>G	p.N45S	COSMIC	PASSENGER/OTHER	BENIGN
170	KO52	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3415A>G	p.S1139G	COSMIC	PASSENGER/OTHER	BENIGN
171	KP4	Cell Line	PANCREAS	ENST00000551964	c.1203T>C	p.C401C	COSMIC	NP	NP
172	L363	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3001C>G	p.Q1001E	COSMIC	PASSENGER/OTHER	BENIGN
173	LIM1215	Cell Line	LARGE_INTESTINE	ENST00000551964	c.1144T>C	p.Y382H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
174	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000551964	c.2346T>C	p.N782N	COSMIC	NP	NP
175	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.2120T>C	p.F707S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
176	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-5T>G	p.?	COSMIC	NP	NP
177	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-6T>G	p.?	COSMIC	NP	NP
178	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-7T>A	p.?	COSMIC	NP	NP
179	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-8T>A	p.?	COSMIC	NP	NP
180	LS180	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3381C>T	p.N1127N	COSMIC	NP	NP
181	MCC13	Cell Line	SKIN	ENST00000551964	c.323C>T	p.S108L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
182	MCC13	Cell Line	SKIN	ENST00000551964	c.3601-8C>T	p.?	COSMIC	NP	NP
183	MCC13	Cell Line	SKIN	ENST00000551964	c.638C>T	p.S213F	COSMIC	PASSENGER/OTHER	BENIGN
184	MCC13	Cell Line	SKIN	ENST00000551964	c.888C>T	p.S296S	COSMIC	NP	NP
185	MDST8	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3457-7T>C	p.?	COSMIC	NP	NP
186	MN60	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
187	NCIH1155	Cell Line	LUNG	ENST00000551964	c.2114G>A	p.C705Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
188	NCIH1666	Cell Line	LUNG	ENST00000551964	c.2825A>T	p.H942L	COSMIC	PASSENGER/OTHER	BENIGN
189	NCIH1734	Cell Line	LUNG	ENST00000551964	c.2280T>C	p.S760S	COSMIC	NP	NP
190	NCIH2009	Cell Line	LUNG	ENST00000551964	c.392A>T	p.K131M	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
191	NCIH2227	Cell Line	LUNG	ENST00000551964	c.2357T>A	p.F786Y	COSMIC	PASSENGER/OTHER	BENIGN
192	NCIH2444	Cell Line	LUNG	ENST00000551964	c.2382A>G	p.Q794Q	COSMIC	NP	NP
193	NCIH2444	Cell Line	LUNG	ENST00000551964	c.2442G>T	p.M814I	COSMIC	PASSENGER/OTHER	BENIGN
194	NCIH345	Cell Line	LUNG	ENST00000551964	c.3626C>G	p.S1209C	COSMIC	PASSENGER/OTHER	BENIGN
195	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000551964	c.1526G>A	p.W509*	COSMIC	NP	NP
196	OSC19	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000551964	c.107C>T	p.T36I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
197	OVK18	Cell Line	OVARY	ENST00000551964	c.101T>C	p.F34S	COSMIC	PASSENGER/OTHER	BENIGN
198	SARC9371	Cell Line	BONE	ENST00000551964	c.1495-5T>G	p.?	COSMIC	NP	NP
199	SARC9371	Cell Line	BONE	ENST00000551964	c.535C>T	p.P179S	COSMIC	PASSENGER/OTHER	BENIGN
200	SBC3	Cell Line	LUNG	ENST00000551964	c.204C>T	p.Y68Y	COSMIC	NP	NP
201	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000551964	c.1301G>A	p.R434H	COSMIC	PASSENGER/OTHER	BENIGN
202	SNU407	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-6T>G	p.?	COSMIC	NP	NP
203	SNU407	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-8T>A	p.?	COSMIC	NP	NP
204	SNU81	Cell Line	LARGE_INTESTINE	ENST00000551964	c.217A>G	p.N73D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
205	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000551964	c.239A>T	p.Y80F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
206	SUPHD1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
207	SW48	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3441C>T	p.D1147D	COSMIC	NP	NP
208	YT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.2059A>G	p.M687V	COSMIC	PASSENGER/OTHER	BENIGN
209	639V	Cell Line	URINARY TRACT	NP_863651	c.803_804delGT	p.S268fs	CCLE	NP	NP
210	A498	Cell Line	KIDNEY	NP_863651	c.1474G>A	p.A492T	CCLE	PASSENGER/OTHER	Probably Damaging
211	AGS	Cell Line	STOMACH	NP_863651	c.3457A>G	p.I1153V	CCLE	PASSENGER/OTHER	Benign
212	BICR56	Cell Line	UPPER AERODIGESTIVE TRACT	NP_863651	c.1783C>G	p.L595V	CCLE	PASSENGER/OTHER	Benign
213	CL34	Cell Line	LARGE INTESTINE	NP_863651	c.697C>T	p.R233C	CCLE	PASSENGER/OTHER	Benign
214	CORL47	Cell Line	LUNG	NP_863651	c.38G>C	p.R13T	CCLE	PASSENGER/OTHER	Possibly Damaging
215	CW2	Cell Line	LARGE INTESTINE	NP_863651	c.1746G>A	p.L582L	CCLE	NP	NP
216	CW2	Cell Line	LARGE INTESTINE	NP_863651	c.614G>A	p.R205Q	CCLE	PASSENGER/OTHER	Probably Damaging
217	DMS53	Cell Line	LUNG	NP_863651	c.2947G>A	p.G983R	CCLE	PASSENGER/OTHER	Probably Damaging
218	EN	Cell Line	ENDOMETRIUM	NP_863651	c.3391C>T	p.R1131C	CCLE	PASSENGER/OTHER	Probably Damaging
219	HCC202	Cell Line	BREAST	NP_863651	c.1357C>T	p.L453F	CCLE	PASSENGER/OTHER	Probably Damaging
220	HCC366	Cell Line	LUNG	NP_863651	c.1201T>C	p.C401R	CCLE	PASSENGER/OTHER	Probably Damaging
221	HEC108	Cell Line	ENDOMETRIUM	NP_863651	c.1798_1798delA	p.K600fs	CCLE	NP	NP
222	HEC1B	Cell Line	ENDOMETRIUM	NP_863651	c.2023T>C	p.C675R	CCLE	PASSENGER/OTHER	Probably Damaging
223	HEC50B	Cell Line	ENDOMETRIUM	NP_863651	c.3527A>C	p.H1176P	CCLE	CANCER	Probably Damaging
224	HRT18	Cell Line	LARGE INTESTINE	NP_863651	c.964C>A	p.L322I	CCLE	PASSENGER/OTHER	Probably Damaging
225	HS698T	Cell Line	LARGE INTESTINE	NP_863651	c.548A>G	p.H183R	CCLE	PASSENGER/OTHER	Probably Damaging
226	IM95	Cell Line	STOMACH	NP_863651	c.1823G>A	p.R608H	CCLE	PASSENGER/OTHER	Possibly Damaging
227	IM95	Cell Line	STOMACH	NP_863651	c.3263T>C	p.V1088A	CCLE	PASSENGER/OTHER	Possibly Damaging
228	JHH7	Cell Line	LIVER	NP_863651	c.181C>G	p.L61V	CCLE	PASSENGER/OTHER	Probably Damaging
229	KCL22	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_863651	c.1655G>A	p.G552E	CCLE	PASSENGER/OTHER	Probably Damaging
230	L363	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_863651	c.3001C>G	p.Q1001E	CCLE	PASSENGER/OTHER	Benign
231	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_863651	c.1797_1798insA	p.N599fs	CCLE	NP	NP
232	LOVO	Cell Line	LARGE INTESTINE	NP_863651	c.2120T>C	p.F707S	CCLE	PASSENGER/OTHER	Probably Damaging
233	LS411N	Cell Line	LARGE INTESTINE	NP_863651	c.676C>A	p.R226S	CCLE	PASSENGER/OTHER	Probably Damaging
234	MFE319	Cell Line	ENDOMETRIUM	NP_863651	c.1797_1798insA	p.N599fs	CCLE	NP	NP
235	NCIH1339	Cell Line	LUNG	NP_863651	c.2207G>A	p.R736Q	CCLE	PASSENGER/OTHER	Possibly Damaging
236	NCIH1385	Cell Line	LUNG	NP_863651	c.3388G>T	p.V1130L	CCLE	PASSENGER/OTHER	Probably Damaging
237	NCIH1666	Cell Line	LUNG	NP_863651	c.2825A>T	p.H942L	CCLE	PASSENGER/OTHER	Benign
238	SNU81	Cell Line	LARGE INTESTINE	NP_863651	c.217A>G	p.N73D	CCLE	PASSENGER/OTHER	Possibly Damaging
239	SNUC2A	Cell Line	LARGE INTESTINE	NP_863651	c.239A>T	p.Y80F	CCLE	PASSENGER/OTHER	Probably Damaging
240	YD38	Cell Line	UPPER AERODIGESTIVE TRACT	NP_863651	c.3740T>C	p.L1247S	CCLE	PASSENGER/OTHER	Possibly Damaging
241	09-044	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000551964	c.1431G>T	p.Q477H	COSMIC	NP	NP
242	585267	Tumour	LUNG	ENST00000551964	c.793A>G	p.R265G	COSMIC	NP	NP
243	587222	Tumour	LARGE INTESTINE	ENST00000551964	c.2773G>T	p.E925*	COSMIC	NP	NP
244	587224	Tumour	LARGE INTESTINE	ENST00000551964	c.2474A>C	p.D825A	COSMIC	NP	NP
245	587290	Tumour	LARGE INTESTINE	ENST00000551964	c.418C>T	p.L140F	COSMIC	NP	NP
246	587376	Tumour	LARGE INTESTINE	ENST00000551964	c.2329G>T	p.E777*	COSMIC	NP	NP
247	CLL063	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000551964	c.1840C>G	p.H614D	COSMIC	NP	NP
248	CRC-9	Tumour	LARGE INTESTINE	ENST00000551964	c.1712C>T	p.P571L	COSMIC	NP	NP
249	H1155	Cell Line	LUNG	ENST00000551964	c.2114G>A	p.C705Y	COSMIC	NP	NP
250	H2009	Cell Line	LUNG	ENST00000551964	c.392A>T	p.K131M	COSMIC	NP	NP
251	HCC139T	Tumour	LIVER	ENST00000551964	c.3127C>T	p.H1043Y	COSMIC	NP	NP
252	HCC17T	Tumour	LIVER	ENST00000551964	c.2156G>A	p.G719E	COSMIC	NP	NP
253	HCC2998	Cell Line	LARGE INTESTINE	ENST00000551964	c.3224G>A	p.G1075E	COSMIC	NP	NP
254	HCC6T	Tumour	LIVER	ENST00000551964	c.3135A>T	p.E1045D	COSMIC	NP	NP
255	LUAD-5V8LT	Tumour	LUNG	ENST00000551964	c.1062G>T	p.R354S	COSMIC	NP	NP
256	ME002T	Tumour	SKIN	ENST00000551964	c.3601T>C	p.W1201R	COSMIC	NP	NP
257	MI2	Tumour	LARGE INTESTINE	ENST00000551964	c.2651G>A	p.W884*	COSMIC	NP	NP
258	NCI-H2009	Cell Line	LUNG	ENST00000551964	c.392A>T	p.K131M	COSMIC	NP	NP
259	P56	Tumour	LIVER	ENST00000551964	c.153A>T	p.Q51H	COSMIC	NP	NP
260	PD6763a	Tumour	NS	ENST00000551964	c.1754A>G	p.K585R	COSMIC	NP	NP
261	RK046	Tumour	C01 LIVER	ENST00000551964	c.2248A>G	p.R750G	COSMIC	NP	NP
262	RK126	Tumour	C01 LIVER	ENST00000551964	c.2954T>G	p.I985S	COSMIC	NP	NP
263	RK159	Tumour	C01 LIVER	ENST00000551964	c.1406A>G	p.Q469R	COSMIC	NP	NP
264	S00827	Tumour	LUNG	ENST00000551964	c.1396A>T	p.R466*	COSMIC	NP	NP
265	TARGET-30-PASXGP	Tumour	AUTONOMIC GANGLIA	ENST00000551964	c.1879G>C	p.G627R	COSMIC	NP	NP
266	TCGA-05-4432-01	Tumour	LUNG	ENST00000551964	c.2014A>G	p.I672V	COSMIC	NP	NP
267	TCGA-09-1665-01	Tumour	OVARY	ENST00000551964	c.1435G>A	p.D479N	COSMIC	NP	NP
268	TCGA-13-0923-01	Tumour	OVARY	ENST00000551964	c.437A>T	p.E146V	COSMIC	NP	NP
269	TCGA-22-4613-01	Tumour	LUNG	ENST00000551964	c.236G>T	p.G79V	COSMIC	NP	NP
270	TCGA-38-4625-01	Tumour	LUNG	ENST00000551964	c.2485A>T	p.S829C	COSMIC	NP	NP
271	TCGA-39-5022-01	Tumour	LUNG	ENST00000551964	c.2135A>G	p.H712R	COSMIC	NP	NP
272	TCGA-50-5044-01	Tumour	LUNG	ENST00000551964	c.771G>A	p.Q257Q	COSMIC	NP	NP
273	TCGA-55-6985-01	Tumour	LUNG	ENST00000551964	c.2829A>T	p.I943I	COSMIC	NP	NP
274	TCGA-55-7914-01	Tumour	LUNG	ENST00000551964	c.149A>T	p.Q50L	COSMIC	NP	NP
275	TCGA-66-2766-01	Tumour	LUNG	ENST00000551964	c.945A>T	p.K315N	COSMIC	NP	NP
276	TCGA-66-2788-01	Tumour	LUNG	ENST00000551964	c.1455C>G	p.N485K	COSMIC	NP	NP
277	TCGA-67-4679-01	Tumour	LUNG	ENST00000551964	c.613C>A	p.R205R	COSMIC	NP	NP
278	TCGA-78-7537-01	Tumour	LUNG	ENST00000551964	c.2068G>A	p.E690K	COSMIC	NP	NP
279	TCGA-85-6561-01	Tumour	LUNG	ENST00000551964	c.2115C>T	p.C705C	COSMIC	NP	NP
280	TCGA-95-7944-01	Tumour	LUNG	ENST00000551964	c.3121C>A	p.R1041R	COSMIC	NP	NP
281	TCGA-A5-A0GV-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1387C>T	p.Q463*	COSMIC	NP	NP
282	TCGA-A6-2676-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1812G>A	p.T604T	COSMIC	NP	NP
283	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
284	TCGA-A6-5666-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1436A>G	p.D479G	COSMIC	NP	NP
285	TCGA-AA-3502-01	Tumour	LARGE INTESTINE	ENST00000551964	c.437A>G	p.E146G	COSMIC	NP	NP
286	TCGA-AA-3516-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798_1799delAA	p.N602fs*23	COSMIC	NP	NP
287	TCGA-AA-3548-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1377G>A	p.K459K	COSMIC	NP	NP
288	TCGA-AA-3712-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
289	TCGA-AA-3713-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2615G>A	p.R872H	COSMIC	NP	NP
290	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1655G>A	p.G552E	COSMIC	NP	NP
291	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2510C>T	p.T837M	COSMIC	NP	NP
292	TCGA-AA-3950-01	Tumour	LARGE INTESTINE	ENST00000551964	c.3673G>A	p.V1225M	COSMIC	NP	NP
293	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2339G>T	p.S780I	COSMIC	NP	NP
294	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2595G>A	p.E865E	COSMIC	NP	NP
295	TCGA-AA-3984-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1812G>A	p.T604T	COSMIC	NP	NP
296	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1539A>C	p.K513N	COSMIC	NP	NP
297	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1301G>A	p.R434H	COSMIC	NP	NP
298	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000551964	c.796G>T	p.D266Y	COSMIC	NP	NP
299	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1608+1_1608+2insTA	p.?	COSMIC	NP	NP
300	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1939G>T	p.G647*	COSMIC	NP	NP
301	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2304+2T>C	p.?	COSMIC	NP	NP
302	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1505C>A	p.A502D	COSMIC	NP	NP
303	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1132G>T	p.D378Y	COSMIC	NP	NP
304	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2316G>A	p.A772A	COSMIC	NP	NP
305	TCGA-B0-5098-01	Tumour	KIDNEY	ENST00000551964	c.2658T>C	p.H886H	COSMIC	NP	NP
306	TCGA-B5-A0JR-01	Tumour	ENDOMETRIUM	ENST00000551964	c.3184T>C	p.S1062P	COSMIC	NP	NP
307	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1055G>T	p.R352I	COSMIC	NP	NP
308	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2305-1G>T	p.?	COSMIC	NP	NP
309	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000551964	c.3649G>T	p.G1217*	COSMIC	NP	NP
310	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000551964	c.614G>A	p.R205Q	COSMIC	NP	NP
311	TCGA-BG-A0MS-01	Tumour	ENDOMETRIUM	ENST00000551964	c.682C>T	p.R228C	COSMIC	NP	NP
312	TCGA-BH-A0HP-01	Tumour	BREAST	ENST00000551964	c.247C>T	p.L83F	COSMIC	NP	NP
313	TCGA-BH-A1FC-01	Tumour	BREAST	ENST00000551964	c.1975G>A	p.E659K	COSMIC	NP	NP
314	TCGA-BK-A0C9-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1593T>C	p.H531H	COSMIC	NP	NP
315	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2038A>C	p.K680Q	COSMIC	NP	NP
316	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000551964	c.2794G>T	p.E932*	COSMIC	NP	NP
317	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000551964	c.574A>G	p.K192E	COSMIC	NP	NP
318	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000551964	c.176T>C	p.M59T	COSMIC	NP	NP
319	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000551964	c.508G>T	p.D170Y	COSMIC	NP	NP
320	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000551964	c.3040G>A	p.D1014N	COSMIC	NP	NP
321	TCGA-CJ-5672-01	Tumour	KIDNEY	ENST00000551964	c.3191A>G	p.D1064G	COSMIC	NP	NP
322	TCGA-CK-4947-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
323	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000551964	c.987A>G	p.A329A	COSMIC	NP	NP
324	TCGA-CM-5341-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2365A>T	p.N789Y	COSMIC	NP	NP
325	TCGA-CM-6170-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
326	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2058T>C	p.S686S	COSMIC	NP	NP
327	TCGA-CM-6674-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
328	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000551964	c.1249G>A	p.E417K	COSMIC	NP	NP
329	TCGA-D1-A160-01	Tumour	ENDOMETRIUM	ENST00000551964	c.135T>C	p.N45N	COSMIC	NP	NP
330	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000551964	c.575A>C	p.K192T	COSMIC	NP	NP
331	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000551964	c.2358delC	p.F787fs*2	COSMIC	NP	NP
332	TCGA-D5-5540-01	Tumour	LARGE INTESTINE	ENST00000551964	c.437A>G	p.E146G	COSMIC	NP	NP
333	TCGA-D5-6535-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
334	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1731T>G	p.Y577*	COSMIC	NP	NP
335	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
336	TCGA-DC-6155-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
337	TCGA-DY-A0XA-01	Tumour	LARGE INTESTINE	ENST00000551964	c.392A>G	p.K131R	COSMIC	NP	NP
338	TCGA-E9-A1N3-01	Tumour	BREAST	ENST00000551964	c.1997C>G	p.S666C	COSMIC	NP	NP
339	TCGA-EI-6507-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
340	TCGA-EJ-5496-01	Tumour	PROSTATE	ENST00000551964	c.511C>T	p.H171Y	COSMIC	NP	NP
341	TCGA-F4-6703-01	Tumour	LARGE INTESTINE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
342	TCGA-G2-A2ES-01	Tumour	URINARY TRACT	ENST00000551964	c.3500C>T	p.P1167L	COSMIC	NP	NP
343	TCGA-G4-6299-01	Tumour	LARGE INTESTINE	ENST00000551964	c.436G>A	p.E146K	COSMIC	NP	NP
344	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000551964	c.438A>G	p.E146E	COSMIC	NP	NP
345	WA47	Tumour	PROSTATE	ENST00000551964	c.3679C>T	p.P1227S	COSMIC	NP	NP
346	YUDUTY	Tumour	SKIN	ENST00000551964	c.1522G>A	p.D508N	COSMIC	NP	NP
347	YUGOE	Tumour	SKIN	ENST00000551964	c.2021C>T	p.T674I	COSMIC	NP	NP
348	ccRCC-41	Tumour	KIDNEY	ENST00000551964	c.1799A>G	p.K600R	COSMIC	NP	NP
349	ccRCC-75	Tumour	KIDNEY	ENST00000551964	c.1309T>A	p.L437I	COSMIC	NP	NP
350	pfg008T	Tumour	STOMACH	ENST00000551964	c.59T>C	p.I20T	COSMIC	NP	NP
351	pfg019T	Tumour	STOMACH	ENST00000551964	c.139-10delt	p.?	COSMIC	NP	NP
352	22RV1	Cell Line	PROSTATE	ENST00000551964	c.205G>A	p.V69I	COSMIC	PASSENGER/OTHER	BENIGN
353	A498	Cell Line	KIDNEY	ENST00000551964	c.1474G>A	p.A492T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
354	AGS	Cell Line	STOMACH	ENST00000551964	c.3457A>G	p.I1153V	COSMIC	PASSENGER/OTHER	BENIGN
355	BFTC905	Cell Line	URINARY_TRACT	ENST00000551964	c.2274G>A	p.L758L	COSMIC	NP	NP
356	CA922	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000551964	c.697C>T	p.R233C	COSMIC	PASSENGER/OTHER	BENIGN
357	CCRFCEM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3286G>A	p.D1096N	COSMIC	PASSENGER/OTHER	BENIGN
358	CCRFCEM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3412G>A	p.D1138N	COSMIC	PASSENGER/OTHER	BENIGN
359	CL34	Cell Line	LARGE_INTESTINE	ENST00000551964	c.697C>T	p.R233C	COSMIC	PASSENGER/OTHER	BENIGN
360	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
361	CW2	Cell Line	LARGE_INTESTINE	ENST00000551964	c.201C>G	p.S67S	COSMIC	NP	NP
362	CW2	Cell Line	LARGE_INTESTINE	ENST00000551964	c.614G>A	p.R205Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
363	DMS53	Cell Line	LUNG	ENST00000551964	c.2947G>A	p.G983R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
364	EN	Cell Line	ENDOMETRIUM	ENST00000551964	c.3391C>T	p.R1131C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
365	GP5D	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-8T>A	p.?	COSMIC	NP	NP
366	H2810	Cell Line	PLEURA	ENST00000551964	c.3007A>G	p.K1003E	COSMIC	PASSENGER/OTHER	BENIGN
367	H2818	Cell Line	PLEURA	ENST00000551964	c.3457-7T>C	p.?	COSMIC	NP	NP
368	HCC202	Cell Line	BREAST	ENST00000551964	c.1357C>T	p.L453F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
369	HCC2218	Cell Line	BREAST	ENST00000551964	c.2875C>T	p.L959L	COSMIC	NP	NP
370	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000551964	c.177G>T	p.M59I	COSMIC	PASSENGER/OTHER	BENIGN
371	HCC366	Cell Line	LUNG	ENST00000551964	c.1201T>C	p.C401R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
372	IM95	Cell Line	STOMACH	ENST00000551964	c.1823G>A	p.R608H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
373	IM95	Cell Line	STOMACH	ENST00000551964	c.3263T>C	p.V1088A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
374	JHH7	Cell Line	LIVER	ENST00000551964	c.181C>G	p.L61V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
375	JHOS4	Cell Line	OVARY	ENST00000551964	c.134A>G	p.N45S	COSMIC	PASSENGER/OTHER	BENIGN
376	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1655G>A	p.G552E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
377	KMH2	Cell Line	THYROID	ENST00000551964	c.134A>G	p.N45S	COSMIC	PASSENGER/OTHER	BENIGN
378	KO52	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3415A>G	p.S1139G	COSMIC	PASSENGER/OTHER	BENIGN
379	KP4	Cell Line	PANCREAS	ENST00000551964	c.1203T>C	p.C401C	COSMIC	NP	NP
380	L363	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.3001C>G	p.Q1001E	COSMIC	PASSENGER/OTHER	BENIGN
381	LIM1215	Cell Line	LARGE_INTESTINE	ENST00000551964	c.1144T>C	p.Y382H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
382	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000551964	c.2346T>C	p.N782N	COSMIC	NP	NP
383	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.2120T>C	p.F707S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
384	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-5T>G	p.?	COSMIC	NP	NP
385	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-6T>G	p.?	COSMIC	NP	NP
386	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-7T>A	p.?	COSMIC	NP	NP
387	LOVO	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-8T>A	p.?	COSMIC	NP	NP
388	LS180	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3381C>T	p.N1127N	COSMIC	NP	NP
389	MCC13	Cell Line	SKIN	ENST00000551964	c.323C>T	p.S108L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
390	MCC13	Cell Line	SKIN	ENST00000551964	c.3601-8C>T	p.?	COSMIC	NP	NP
391	MCC13	Cell Line	SKIN	ENST00000551964	c.638C>T	p.S213F	COSMIC	PASSENGER/OTHER	BENIGN
392	MCC13	Cell Line	SKIN	ENST00000551964	c.888C>T	p.S296S	COSMIC	NP	NP
393	MDST8	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3457-7T>C	p.?	COSMIC	NP	NP
394	MN60	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
395	NCIH1155	Cell Line	LUNG	ENST00000551964	c.2114G>A	p.C705Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
396	NCIH1666	Cell Line	LUNG	ENST00000551964	c.2825A>T	p.H942L	COSMIC	PASSENGER/OTHER	BENIGN
397	NCIH1734	Cell Line	LUNG	ENST00000551964	c.2280T>C	p.S760S	COSMIC	NP	NP
398	NCIH2009	Cell Line	LUNG	ENST00000551964	c.392A>T	p.K131M	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
399	NCIH2227	Cell Line	LUNG	ENST00000551964	c.2357T>A	p.F786Y	COSMIC	PASSENGER/OTHER	BENIGN
400	NCIH2444	Cell Line	LUNG	ENST00000551964	c.2382A>G	p.Q794Q	COSMIC	NP	NP
401	NCIH2444	Cell Line	LUNG	ENST00000551964	c.2442G>T	p.M814I	COSMIC	PASSENGER/OTHER	BENIGN
402	NCIH345	Cell Line	LUNG	ENST00000551964	c.3626C>G	p.S1209C	COSMIC	PASSENGER/OTHER	BENIGN
403	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000551964	c.1526G>A	p.W509*	COSMIC	NP	NP
404	OSC19	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000551964	c.107C>T	p.T36I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
405	OVK18	Cell Line	OVARY	ENST00000551964	c.101T>C	p.F34S	COSMIC	PASSENGER/OTHER	BENIGN
406	SARC9371	Cell Line	BONE	ENST00000551964	c.1495-5T>G	p.?	COSMIC	NP	NP
407	SARC9371	Cell Line	BONE	ENST00000551964	c.535C>T	p.P179S	COSMIC	PASSENGER/OTHER	BENIGN
408	SBC3	Cell Line	LUNG	ENST00000551964	c.204C>T	p.Y68Y	COSMIC	NP	NP
409	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000551964	c.1301G>A	p.R434H	COSMIC	PASSENGER/OTHER	BENIGN
410	SNU407	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-6T>G	p.?	COSMIC	NP	NP
411	SNU407	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3205-8T>A	p.?	COSMIC	NP	NP
412	SNU81	Cell Line	LARGE_INTESTINE	ENST00000551964	c.217A>G	p.N73D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
413	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000551964	c.239A>T	p.Y80F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
414	SUPHD1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.1798delA	p.N602fs*8	COSMIC	NP	NP
415	SW48	Cell Line	LARGE_INTESTINE	ENST00000551964	c.3441C>T	p.D1147D	COSMIC	NP	NP
416	YT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000551964	c.2059A>G	p.M687V	COSMIC	PASSENGER/OTHER	BENIGN

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.7538	5.7488	0.0502	-0.0235
BILIARY TRACT	5.3895	5.1949	0.0035	-0.0575
BONE	5.7709	5.7355	0.1125	-0.002334
BREAST	5.6316	5.62015	-0.0179	-0.01295
CENTRAL NERVOUS SYSTEM	5.6984	5.6703	-0.0092	-0.0323
ENDOMETRIUM	5.7804	5.8079	0.0201	0.0004179
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.0952	6.0559	-0.0479	-0.01176
KIDNEY	5.8138	5.8964	0.1486	0.0916
LARGE INTESTINE	5.8166	5.8288	0.0309	0.0073
LIVER	5.7684	5.7393	0.1135	0.1193
LUNG	5.6843	5.63235	0.0833	0.08328
OESOPHAGUS	5.6149	5.5518	0.0397	0.06
OVARY	5.6552	5.667	-0.0410	0.01789
PANCREAS	5.6427	5.6644	-0.0135	0.1056
PLEURA	5.5705	5.5435	0.0397	0.02444
PROSTATE	5.3973	5.3901	0.1318	0.07815
SALIVARY GLAND	5.9268	5.9268	-0.3863	-0.3863
SKIN	5.7666	5.7846	-0.0234	0.0029
SMALL INTESTINE	5.6812	5.6812	0.0043	0.0043
SOFT TISSUE	6.0311	5.9776	-0.0361	-0.01543
STOMACH	5.5848	5.57315	-0.0876	-0.01765
THYROID	5.7764	5.82035	-0.0139	0.022925
UPPER AERODIGESTIVE TRACT	5.6124	5.58105	0.0260	0.069525
URINARY TRACT	5.7416	5.6055	0.1186	0.0797

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	6	89	3.1e-18
PF00931	NB-ARC	129	410	9.6e-75
PF00400	WD40	612	642	6.3e-06
PF00400	WD40	648	685	9.9e-10
PF00400	WD40	689	729	5.4e-07
PF00400	WD40	734	771	1.2e-12
PF12657	TFIIIC_delta	801	830	0.071
PF00400	WD40	875	910	2.5e-07
PF00400	WD40	1002	1031	0.007
PF00400	WD40	1039	1071	0.0029
PF00400	WD40	1079	1113	9.8e-06
PF00400	WD40	1119	1155	1.7e-07
PF00400	WD40	1175	1196	0.0023
PF00619	CARD	6	89	3.1e-18
PF00931	NB-ARC	129	410	9.6e-75
PF00400	WD40	612	642	6.3e-06
PF00400	WD40	648	685	9.9e-10
PF00400	WD40	689	729	5.4e-07
PF00400	WD40	734	771	1.2e-12
PF12657	TFIIIC_delta	801	830	0.071
PF00400	WD40	875	910	2.5e-07
PF00400	WD40	1002	1031	0.007
PF00400	WD40	1039	1071	0.0029
PF00400	WD40	1079	1113	9.8e-06
PF00400	WD40	1119	1155	1.7e-07
PF00400	WD40	1175	1196	0.0023

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
APAF1	APAF1	APAF1	ENSP00000334558	O14727
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O14727	APAF1	ENSP00000334558	APAF1	O14727
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
APAF1	ENSP00000334558	602233	O14727	PA24868

Protein: APAF1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS