ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587284	Tumour	LARGE INTESTINE	ENST00000465139	c.682C>T	p.L228F	COSMIC	NP	NP
2	LUAD-LIP77	Tumour	LUNG	ENST00000465139	c.328-1G>T	p.?	COSMIC	NP	NP
3	LUAD-NYU201	Tumour	LUNG	ENST00000465139	c.160C>G	p.L54V	COSMIC	NP	NP
4	LUAD-S00484	Tumour	LUNG	ENST00000465139	c.463G>T	p.A155S	COSMIC	NP	NP
5	TCGA-38-7271-01	Tumour	LUNG	ENST00000465139	c.172G>A	p.A58T	COSMIC	NP	NP
6	TCGA-39-5016-01	Tumour	LUNG	ENST00000465139	c.39C>A	p.N13K	COSMIC	NP	NP
7	TCGA-50-5946-01	Tumour	LUNG	ENST00000465139	c.473C>T	p.S158L	COSMIC	NP	NP
8	TCGA-50-5946-02	Tumour	LUNG	ENST00000465139	c.473C>T	p.S158L	COSMIC	NP	NP
9	TCGA-69-7980-01	Tumour	LUNG	ENST00000465139	c.736G>C	p.E246Q	COSMIC	NP	NP
10	TCGA-A3-3316-01	Tumour	KIDNEY	ENST00000465139	c.34C>T	p.R12W	COSMIC	NP	NP
11	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000465139	c.311G>A	p.S104N	COSMIC	NP	NP
12	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000465139	c.436G>A	p.D146N	COSMIC	NP	NP
13	TCGA-D1-A0ZO-01	Tumour	ENDOMETRIUM	ENST00000465139	c.194A>C	p.K65T	COSMIC	NP	NP
14	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000465139	c.27A>G	p.L9L	COSMIC	NP	NP
15	TCGA-DK-A1AC-01	Tumour	URINARY TRACT	ENST00000465139	c.87G>A	p.S29S	COSMIC	NP	NP
16	639V	Cell Line	URINARY_TRACT	ENST00000465139	c.691G>A	p.E231K	COSMIC	PASSENGER/OTHER	BENIGN
17	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.22C>T	p.H8Y	COSMIC	PASSENGER/OTHER	BENIGN
18	DJM1	Cell Line	SKIN	ENST00000465139	c.319G>C	p.E107Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
19	ESO51	Cell Line	OESOPHAGUS	ENST00000465139	c.328-3C>T	p.?	COSMIC	NP	NP
20	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.273G>A	p.T91T	COSMIC	NP	NP
21	HGC27	Cell Line	STOMACH	ENST00000465139	c.694_696delGAA	p.E232delE	COSMIC	NP	NP
22	KMOE2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.255A>G	p.E85E	COSMIC	NP	NP
23	LS123	Cell Line	LARGE_INTESTINE	ENST00000465139	c.153C>G	p.N51K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
24	LS411N	Cell Line	LARGE_INTESTINE	ENST00000465139	c.113C>T	p.T38I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
25	NCIH1155	Cell Line	LUNG	ENST00000465139	c.12C>T	p.G4G	COSMIC	NP	NP
26	NCIH2087	Cell Line	LUNG	ENST00000465139	c.290G>T	p.G97V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
27	NCIH2342	Cell Line	LUNG	ENST00000465139	c.140T>A	p.L47*	COSMIC	NP	NP
28	NCIH358	Cell Line	LUNG	ENST00000465139	c.204+8G>C	p.?	COSMIC	NP	NP
29	NCIH650	Cell Line	LUNG	ENST00000465139	c.57G>A	p.V19V	COSMIC	NP	NP
30	NUDUL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.153C>T	p.N51N	COSMIC	NP	NP
31	P30OHK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.689-6T>A	p.?	COSMIC	NP	NP
32	SKMEL28	Cell Line	SKIN	ENST00000465139	c.564C>T	p.D188D	COSMIC	NP	NP
33	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000465139	c.273G>A	p.T91T	COSMIC	NP	NP
34	SNU81	Cell Line	LARGE_INTESTINE	ENST00000465139	c.61G>T	p.E21*	COSMIC	NP	NP
35	SNU81	Cell Line	LARGE_INTESTINE	ENST00000465139	c.709C>T	p.R237*	COSMIC	NP	NP
36	TE10	Cell Line	OESOPHAGUS	ENST00000465139	c.564C>G	p.D188E	COSMIC	PASSENGER/OTHER	BENIGN
37	VMRCLCD	Cell Line	LUNG	ENST00000465139	c.459G>T	p.K153N	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
38	587284	Tumour	LARGE INTESTINE	ENST00000465139	c.682C>T	p.L228F	COSMIC	NP	NP
39	LUAD-LIP77	Tumour	LUNG	ENST00000465139	c.328-1G>T	p.?	COSMIC	NP	NP
40	LUAD-NYU201	Tumour	LUNG	ENST00000465139	c.160C>G	p.L54V	COSMIC	NP	NP
41	LUAD-S00484	Tumour	LUNG	ENST00000465139	c.463G>T	p.A155S	COSMIC	NP	NP
42	TCGA-38-7271-01	Tumour	LUNG	ENST00000465139	c.172G>A	p.A58T	COSMIC	NP	NP
43	TCGA-39-5016-01	Tumour	LUNG	ENST00000465139	c.39C>A	p.N13K	COSMIC	NP	NP
44	TCGA-50-5946-01	Tumour	LUNG	ENST00000465139	c.473C>T	p.S158L	COSMIC	NP	NP
45	TCGA-50-5946-02	Tumour	LUNG	ENST00000465139	c.473C>T	p.S158L	COSMIC	NP	NP
46	TCGA-69-7980-01	Tumour	LUNG	ENST00000465139	c.736G>C	p.E246Q	COSMIC	NP	NP
47	TCGA-A3-3316-01	Tumour	KIDNEY	ENST00000465139	c.34C>T	p.R12W	COSMIC	NP	NP
48	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000465139	c.311G>A	p.S104N	COSMIC	NP	NP
49	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000465139	c.436G>A	p.D146N	COSMIC	NP	NP
50	TCGA-D1-A0ZO-01	Tumour	ENDOMETRIUM	ENST00000465139	c.194A>C	p.K65T	COSMIC	NP	NP
51	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000465139	c.27A>G	p.L9L	COSMIC	NP	NP
52	TCGA-DK-A1AC-01	Tumour	URINARY TRACT	ENST00000465139	c.87G>A	p.S29S	COSMIC	NP	NP
53	639V	Cell Line	URINARY_TRACT	ENST00000465139	c.691G>A	p.E231K	COSMIC	PASSENGER/OTHER	BENIGN
54	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.22C>T	p.H8Y	COSMIC	PASSENGER/OTHER	BENIGN
55	DJM1	Cell Line	SKIN	ENST00000465139	c.319G>C	p.E107Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
56	ESO51	Cell Line	OESOPHAGUS	ENST00000465139	c.328-3C>T	p.?	COSMIC	NP	NP
57	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.273G>A	p.T91T	COSMIC	NP	NP
58	HGC27	Cell Line	STOMACH	ENST00000465139	c.694_696delGAA	p.E232delE	COSMIC	NP	NP
59	KMOE2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.255A>G	p.E85E	COSMIC	NP	NP
60	LS123	Cell Line	LARGE_INTESTINE	ENST00000465139	c.153C>G	p.N51K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
61	LS411N	Cell Line	LARGE_INTESTINE	ENST00000465139	c.113C>T	p.T38I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
62	NCIH1155	Cell Line	LUNG	ENST00000465139	c.12C>T	p.G4G	COSMIC	NP	NP
63	NCIH2087	Cell Line	LUNG	ENST00000465139	c.290G>T	p.G97V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
64	NCIH2342	Cell Line	LUNG	ENST00000465139	c.140T>A	p.L47*	COSMIC	NP	NP
65	NCIH358	Cell Line	LUNG	ENST00000465139	c.204+8G>C	p.?	COSMIC	NP	NP
66	NCIH650	Cell Line	LUNG	ENST00000465139	c.57G>A	p.V19V	COSMIC	NP	NP
67	NUDUL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.153C>T	p.N51N	COSMIC	NP	NP
68	P30OHK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000465139	c.689-6T>A	p.?	COSMIC	NP	NP
69	SKMEL28	Cell Line	SKIN	ENST00000465139	c.564C>T	p.D188D	COSMIC	NP	NP
70	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000465139	c.273G>A	p.T91T	COSMIC	NP	NP
71	SNU81	Cell Line	LARGE_INTESTINE	ENST00000465139	c.61G>T	p.E21*	COSMIC	NP	NP
72	SNU81	Cell Line	LARGE_INTESTINE	ENST00000465139	c.709C>T	p.R237*	COSMIC	NP	NP
73	TE10	Cell Line	OESOPHAGUS	ENST00000465139	c.564C>G	p.D188E	COSMIC	PASSENGER/OTHER	BENIGN
74	VMRCLCD	Cell Line	LUNG	ENST00000465139	c.459G>T	p.K153N	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	12.2760	12.275	0.0567	0.0209
BILIARY TRACT	11.3697	11.187	0.1767	0.06134
BONE	11.1846	10.918	0.0636	-0.0038
BREAST	10.9830	11.177	-0.1498	-0.02345
CENTRAL NERVOUS SYSTEM	11.2758	11.238	0.0899	0.1116
ENDOMETRIUM	11.5832	11.643	-0.0998	-0.0515
HAEMATOPOIETIC AND LYMPHOID TISSUE	12.0791	12.119	0.0189	0.002112
KIDNEY	10.9560	10.966	-0.0599	-0.01883
LARGE INTESTINE	11.5161	11.544	0.0103	0.017915
LIVER	11.2702	11.415	-0.0315	-0.0564
LUNG	11.5785	11.594	-0.0210	-0.016645
OESOPHAGUS	11.2814	11.3	-0.1077	-0.12248
OVARY	11.4238	11.431	-0.0556	0.02499
PANCREAS	11.4370	11.453	0.0370	0.0847
PLEURA	11.2024	11.226	0.0385	0.0322
PROSTATE	11.4965	11.588	-0.0880	-0.03375
SALIVARY GLAND	10.9680	10.968	-0.2463	-0.2463
SKIN	11.0444	11.078	0.0699	0.0286
SMALL INTESTINE	12.2280	12.228	0.0296	0.02961
SOFT TISSUE	11.6844	11.6085	0.0513	0.0053485
STOMACH	11.6198	11.5915	0.0040	-0.016445
THYROID	11.1720	11.2765	0.0583	0.065
UPPER AERODIGESTIVE TRACT	10.9352	10.879	0.0224	0.021945
URINARY TRACT	11.3111	11.3855	0.0151	-0.01932

Domain ID	Domain Name	Start Site	End Site	E-value
PF14580	LRR_9	49	154	1.6e-10
PF14580	LRR_9	49	154	1.6e-10

Domain ID	Start Site	End Site	E-value
0046830	6	153	8.50e-29
0046830	6	153	8.50e-29

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
ANP32A	ANP32A	ANP32A	ENSP00000417864	P39687
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P39687	ANP32A	ENSP00000417864	ANP32A	P39687
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
ANP32A	ENSP00000417864	600832	P39687	PA134978741

Protein: ANP32A

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2JE0, 2JE1