|
10163
|
BriLife
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Replicating viral vector
|
Phase 1
|
Israel Institute for Biological Research
|
NA
|
NA
|
NA
|
Single dose
|
Intramuscular
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
rVSV-SARS-CoV-2-S Vaccine
|
33816047
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10172
|
COVID-19 aAPC vaccine
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Replicating viral vector
|
Phase 1
|
Shenzhen Geno-Immune Medical Institute
|
2021
|
China
|
6 months - 80 years
|
3 doses on day 0, 14 and 28
|
Subcutaneous
|
NA
|
NA
|
The Covid-19/aAPC vaccine is prepared by applying lentivirus modification with immune-modulatory genes and the viral minigenes to the artificial antigen-presenting cells
|
NA
|
NA
|
NA
|
NA
|
33816047
|
NCT04299724
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10189
|
TMV-083
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Replicating viral vector
|
Phase 1
|
Institut Pasteur
|
2020
|
Belgium
|
18 - 55 years
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
Surface glycoprotein of the SARS-CoV-2
|
NA
|
NA
|
NA
|
NA
|
MV-SARS-CoV-2
|
NA
|
NCT04497298
|
https://clinicaltrials.gov/show/NCT04497298
|
NA
|
|
10191
|
V590-001
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Replicating viral vector
|
Phase 1
|
Merck & Co. Inc.
|
2020
|
USA
|
18 years and above
|
NA
|
Intramuscular
|
NA
|
NA
|
NA
|
US FDA
|
NA
|
NA
|
NA
|
NA
|
NCT04569786
|
https://clinicaltrials.gov/show/NCT04569786
|
NA
|
|
10264
|
DelNS1-2019-nCoV-RBD-OPT1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Replicating viral vector
|
Phase 2
|
Beijing Wantai Biological
|
NA
|
NA
|
NA
|
Single dose
|
Intranasal
|
NA
|
NA
|
NA
|
NA
|
Jiangsu Province Centers for Disease Control and Prevention
|
NA
|
NA
|
33816047
|
NCT04809389
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
https://clinicaltrials.gov/ct2/show/NCT04809389
|
|
10265
|
TMV-o38
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Replicating viral vector
|
Phase 2
|
Merck & Co. Inc.
|
NA
|
NA
|
NA
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
NA
|
NA
|
NA
|
Themis, Sharp & Dohme, Institute Pasteur, Univeristy of Pittsburgh
|
NA
|
V591-001—Measles-vector based
|
33816047
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|