|
10013
|
Covishield
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
AstraZeneca plc, University of Oxford, Serum Institute of India
|
2020
|
England
|
NA
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
SARS-CoV-2 Spike gene to the replication defective chimpanzee adenovirus ChAdOx1
|
NA
|
US FDA
|
NA
|
UK, USA, Japan, South Africa
|
AZD1222,ChAdOx1 nCoV-19, ChAdOx1-S, COVID-19 Vaccine AstraZeneca, AstraZeneca COVID-19 Vaccine, AZD2816,Vaxzevria
|
32328406
|
NA
|
https://pubmed.ncbi.nlm.nih.gov/32328406/
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637436/
|
|
10017
|
Convidecia
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
CanSino Biologics Inc.
|
2020
|
China
|
6 - 59 years
|
2 doses
|
Intramuscular
|
NA
|
Spike protein of SARS-CoV-2 virus
|
Viral vector vaccine using a replication-defective form of the human adenovirus Ad5
|
NMPA
|
Jiangsu Province Centers for Disease Control and Prevention, Insitute of Biotechnology, Academy of Military Medical Sciences, PLA of China
|
China, Chile, Hungary, Malaysia, Mexico, Pakistan
|
Ad5-nCoV
|
32328406
|
NCT04916886
|
https://pubmed.ncbi.nlm.nih.gov/32328406/
|
https://extranet.who.int/pqweb/vaccines/convidecia
|
|
10018
|
JCOVDEN
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
Johnson & Johnson
|
2021
|
USA
|
18 - 65 years
|
Single dose
|
Intramuscular
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
US FDA, WHO
|
NA
|
Netherlands, USA, Argentina, Brazil, Chile, Colombia, Mexico, Peru, Philippines, South Africa, Ukraine, Belgium, Colombia, France, Germany, Philippines, Spain, UK, Europe
|
Ad26.COV2.S, JNJ-78436735,Ad26COVS1, VAC31518,COVID-19 Vaccine Janssen,Johnson & Johnson COVID‑19 vaccine
|
32328406
|
NCT04927936
|
https://pubmed.ncbi.nlm.nih.gov/32328406/
|
https://www.ema.europa.eu/en/documents/product-information/jcovden-previously-covid-19-vaccine-janssen-epar-product-information_en.pdf
|
|
10020
|
JCOVDEN
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
Janssen Pharmaceutical
|
2020
|
Russia
|
NA
|
2 doses 21 days apart
|
Intramuscular
|
NA
|
Heterologous formulation consisting of two human adenovirus vectors, Ad26 and Ad5, both carrying the SARS-CoV-2 spike protein
|
NA
|
US FDA
|
Health Ministry of the Russian Federation
|
NA
|
Ad26.COV2.S, JNJ-78436735,Ad26COVS1, VAC31518,COVID-19 Vaccine Janssen,Johnson & Johnson COVID‑19 vaccine
|
32328406
|
NA
|
https://pubmed.ncbi.nlm.nih.gov/32328406/
|
NA
|
|
10021
|
Gam-COVID-Vac
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
Gamaleya Research Institute of Epidemiology and Microbiology
|
NA
|
Russia
|
NA
|
2 doses 3 weeks apart
|
Intramuscular
|
NA
|
NA
|
NA
|
US FDA
|
Health Ministry of the Russian Federation
|
Russia, Bolivia, Argentina, Algeria, Serbia, Belarus
|
Sputnik-V
|
NA
|
NA
|
https://www.precisionvaccinations.com/vaccines/sputnik-v-vaccine
|
NA
|
|
10022
|
Gam-COVID-Vac
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
Gamaleya Research Institute of Epidemiology and Microbiology
|
NA
|
Russia
|
NA
|
NA
|
Intramuscular
|
NA
|
NA
|
NA
|
EMA
|
NA
|
NA
|
Sputnik-V
|
33324769
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729279/
|
NA
|
|
10044
|
Covishield
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
AstraZeneca plc, University of Oxford, Serum Institute of India
|
2020
|
UK
|
NA
|
NA
|
Intramuscular
|
NA
|
NA
|
Recombinant ChAdOx1 adenoviral vector encoding the Spike protein antigen of the SARS-CoV-2
|
EMA
|
NA
|
NA
|
AZD1222,ChAdOx1 nCoV-19, ChAdOx1-S, COVID-19 Vaccine AstraZeneca, AstraZeneca COVID-19 Vaccine, AZD2816,Vaxzevria
|
NA
|
NA
|
https://extranet.who.int/pqweb/sites/default/files/documents/Status_of_COVID-19_Vaccines_within_WHO_EUL-PQ_evaluation_process-16June2021_Final.pdf
|
NA
|
|
10045
|
Covishield
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
AstraZeneca plc, University of Oxford, Serum Institute of India
|
NA
|
India
|
NA
|
NA
|
Intramuscular
|
NA
|
NA
|
Recombinant ChAdOx1 adenoviral vector encoding the Spike protein antigen of the SARS-CoV-2
|
DCGI
|
NA
|
NA
|
AZD1222,ChAdOx1 nCoV-19, ChAdOx1-S, COVID-19 Vaccine AstraZeneca, AstraZeneca COVID-19 Vaccine, AZD2816,Vaxzevria
|
NA
|
NA
|
https://extranet.who.int/pqweb/sites/default/files/documents/Status_of_COVID-19_Vaccines_within_WHO_EUL-PQ_evaluation_process-16June2021_Final.pdf
|
NA
|
|
10050
|
Covishield
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
AstraZeneca plc, University of Oxford, Serum Institute of India
|
NA
|
UK
|
NA
|
NA
|
Intramuscular
|
NA
|
NA
|
Recombinant ChAdOx1 adenoviral vector encoding the Spike protein antigen of the SARS-CoV-2
|
Japan MHLW
|
NA
|
NA
|
AZD1222,ChAdOx1 nCoV-19, ChAdOx1-S, COVID-19 Vaccine AstraZeneca, AstraZeneca COVID-19 Vaccine, AZD2816,Vaxzevria
|
NA
|
NA
|
https://extranet.who.int/pqweb/sites/default/files/documents/Status_of_COVID-19_Vaccines_within_WHO_EUL-PQ_evaluation_process-16June2021_Final.pdf
|
https://www.who.int/publications/m/item/chadox1-s-recombinant-covid-19-vaccine
|
|
10051
|
Covishield
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
AstraZeneca plc, University of Oxford, Serum Institute of India
|
NA
|
UK
|
NA
|
NA
|
Intramuscular
|
NA
|
NA
|
Recombinant ChAdOx1 adenoviral vector encoding the Spike protein antigen of the SARS-CoV-2
|
Australia TGA
|
NA
|
NA
|
AZD1222,ChAdOx1 nCoV-19, ChAdOx1-S, COVID-19 Vaccine AstraZeneca, AstraZeneca COVID-19 Vaccine, AZD2816,Vaxzevria
|
NA
|
NA
|
https://extranet.who.int/pqweb/sites/default/files/documents/Status_of_COVID-19_Vaccines_within_WHO_EUL-PQ_evaluation_process-16June2021_Final.pdf
|
https://www.who.int/publications/m/item/chadox1-s-recombinant-covid-19-vaccine
|
|
10085
|
Ad26.ZEBOV
|
Ebola
|
Hemorrhagic
|
Zaire ebolavirus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Approved
|
Janssen Pharmaceutical
|
2020
|
USA
|
1 year and above
|
Single dose of Zabdeno on day 0 followed by 0.5mL dose of Mvabea post 8 week
|
Intramuscular
|
NA
|
Adenovirus type 26 encoding the Zaire ebolavirus, Mayinga variant glycoprotein
|
NA
|
US FDA, EMA
|
NA
|
NA
|
MVA-BN-Filo
|
NA
|
NCT02509494
|
https://clinicaltrials.gov/ct2/show/NCT02509494
|
https://clinicaltrials.gov/ct2/show/NCT05284097
|
|
10108
|
Hecolin (Hepatitis vaccine -239)
|
Hepatitis E
|
Hepatitic
|
Hepatitis E virus
|
double stranded DNA
|
Recombinant viral vector
|
Approved
|
Xiamen Innovax Biotech
|
2011
|
China
|
NA
|
3 doses at regimen of 0, 1, and 6 months
|
Intramuscular
|
Aluminum (aluminium hydroxide)
|
Capsid Protein ORF2
|
NA
|
China FDA
|
NA
|
NA
|
Hecolin
|
29546064
|
NCT01014845
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818934/
|
https://www.precisionvaccinations.com/vaccines/hecolin-hepatitis-e-vaccine
|
|
10148
|
MVA-SARS-2-S
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Universitätsklinikum Hamburg-Eppendorf
|
2021
|
Germany
|
18 - 55 years
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
Ludwig-Maximilians, University of Munich
|
NA
|
NA
|
NA
|
NCT04569383
|
https://clinicaltrials.gov/show/NCT04569383
|
NA
|
|
10156
|
VXA-CoV2-1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Vaxart
|
2021
|
USA
|
18 - 55 years
|
2 doses 28 days apart
|
Oral
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
NA
|
33937326
|
NCT04563702
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082173/
|
NA
|
|
10157
|
VXA-CoV2-1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Vaxart
|
2021
|
USA
|
18 - 54 years
|
2 doses 28 days apart
|
Oral
|
NA
|
NA
|
Ad5 adjuvanted Oral Vaccine platform
|
NA
|
NA
|
NA
|
NA
|
33816047
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10160
|
CVXGA1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
CyanVac LLC
|
2021
|
USA
|
18 - 75 years
|
Single dose
|
Intranasal
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
US FDA
|
NA
|
NA
|
PIV5-SARS CoV-2 vaccine
|
NA
|
NCT04954287
|
https://clinicaltrials.gov/ct2/show/NCT04954287
|
NA
|
|
10161
|
COVID-19 rNDV vector vaccine
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Laboratorio Avi-Mex
|
2021
|
Mexico
|
18 - 55 years
|
2 doses 21 days apart
|
Intramuscular
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04871737
|
https://clinicaltrials.gov/ct2/show/study/NCT04871737
|
NA
|
|
10179
|
ChAdV68-S
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Gritstone Oncology
|
2021
|
USA
|
18 years and above
|
2 doses 28 days apart
|
Intramuscular
|
Aluminum (alum)
|
SARS-CoV-2 receptor-binding domain from spike protein
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04760743
|
https://clinicaltrials.gov/ct2/show/NCT04760743
|
NA
|
|
10184
|
SC-Ad6-1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Tetherex Pharmaceuticals Corporation
|
2021
|
Australia
|
18 - 55 years
|
Single or multiple-dose
|
Intramuscular, Intranasal
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04839042
|
https://clinicaltrials.gov/ct2/show/NCT04839042
|
NA
|
|
10196
|
MVA-MERS-S
|
MERS
|
Respiratory
|
MERS-CoV
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Philipps University Marburg Medical Center
|
2020
|
Germany
|
18 - 55 years
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
MERS CoV spike glycoprotein
|
NA
|
NA
|
NA
|
NA
|
NA
|
32325037
|
NCT03615911
|
https://pubmed.ncbi.nlm.nih.gov/32325037/
|
NA
|
|
10197
|
MVA-MERS-S_DF1
|
MERS
|
Respiratory
|
MERS-CoV
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
CTC North GmbH & Co. KG
|
2021
|
Germany
|
18 - 55 years
|
NA
|
Intramuscular
|
NA
|
MERS CoV spike glycoprotein
|
NA
|
NA
|
NA
|
NA
|
NA
|
33341119
|
NCT04119440
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749790/
|
NA
|
|
10202
|
rVSV-EBOV
|
Ebola
|
Hemorrhagic
|
Zaire ebolavirus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Merck & Co. Inc.
|
2014
|
USA
|
18 - 65 years
|
NA
|
Intramuscular
|
NA
|
Zaire Ebola virus glycoprotein
|
Vesicular Stomatitis Virus based
|
NA
|
National Institute of Allergy and Infectious Diseases
|
NA
|
NA
|
27764560
|
NCT02280408
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287303/
|
NA
|
|
10203
|
Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO)/ChAd3-EBO-Z
|
Ebola
|
Hemorrhagic
|
Zaire ebolavirus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
National Institute of Allergy and Infectious Diseases
|
2014
|
USA
|
18 - 65 years
|
NA
|
Intramuscular
|
NA
|
Wild type glycoproteins from Zaire and Sudan strains of Ebolavirus
|
Chimpanzee Adenovirus Vector expressing Zaire and sudan strain glycoprotein
|
NA
|
NA
|
NA
|
NA
|
27764560
|
NCT02231866
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287303/
|
NA
|
|
10208
|
cAd3 Marburg (VRC-MARADC087-00-VP)
|
Marburg hemorrhagic fever
|
Hemorrhagic
|
Marburg virus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
National Institute of Allergy and Infectious Diseases
|
2021
|
USA
|
18 - 50 years
|
Single dose
|
Intramuscular
|
NA
|
Marburg wild type glycoprotein
|
NA
|
US FDA
|
US Military HIV Research Program
|
NA
|
NA
|
NA
|
NCT03475056
|
https://clinicaltrials.gov/ct2/show/NCT03475056?cond=Marburg+hemorrhagic+fever&draw=2&rank=3
|
NA
|
|
10228
|
CHIK001
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
University of Oxford
|
2019
|
NA
|
18 - 50 years
|
NA
|
NA
|
NA
|
Chimpanzee adenovirus expressing CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT03590392
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
https://clinicaltrials.gov/ct2/show/NCT03590392?cond=Chickungunya+Fever&draw=2&rank=29
|
|
10231
|
VLA1533
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Valneva
|
2019
|
Austria
|
18 - 39 years
|
3 doses on day 0, 28 and 56
|
Intramuscular
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT03010228
|
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006919
|
https://clinicaltrials.gov/ct2/show/NCT03010228
|
|
10250
|
COVID-19 Vaccine Nasal Spray
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Xiamen University
|
2021
|
China
|
18 years and above
|
2 doses 14 days apart
|
Intranasal
|
NA
|
NA
|
NA
|
NA
|
University of Hong Kong, Beijing Wantai Biological Pharmacy
|
NA
|
NA
|
33937326
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082173/
|
NA
|
|
10251
|
hAd5-COVID-19
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
ImmunityBio Inc.
|
2021
|
USA
|
18 - 80 years
|
NA
|
Subcutaneous
|
NA
|
Spike & Nucleocapsid protein
|
NA
|
NA
|
NA
|
NA
|
NA
|
33937326
|
NCT04843722
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082173/
|
NA
|
|
10260
|
AV-COVID-19
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Aivita Biomedical Inc.
|
2021
|
USA
|
18 years and above
|
Single dose
|
Intramuscular
|
GM-CSF
|
Spike protein of SARS-CoV-2 virus
|
NA
|
US FDA
|
NA
|
NA
|
NA
|
33816047
|
NCT05007496
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
https://clinicaltrials.gov/ct2/show/NCT05007496
|
|
10261
|
MVA-SARS-2-S
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
City of Hope Medical Center, National Cancer Institute
|
2021
|
USA
|
18 years and above
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
US FDA
|
NA
|
NA
|
COH04S1
|
33816047
|
NCT04977024
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10262
|
hAd5-COVID-19
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
ImmunityBio Inc.
|
2021
|
USA
|
18 - 80 years
|
Single dose
|
Subcutaneous
|
NA
|
Spike & nucleocapsid protein of SARS-CoV-2 virus
|
NA
|
US FDA
|
NA
|
NA
|
NA
|
33816047
|
NCT04843722
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10279
|
COVIVAC
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Icahn School of Medicine, Mahidol University
|
2021
|
Thailand
|
18 - 75 years
|
2 doses 28 days apart
|
Intramuscular
|
CpG 1018
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
ADAPTCOV, NDV-HXP-S vaccine, , HXP-GPOVac, Patria, ButanVac
|
NA
|
NCT04764422
|
https://clinicaltrials.gov/show/NCT04764422
|
NA
|
|
10284
|
MVA-SARS-2-ST
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
German Center for Infection Research
|
2021
|
Germany
|
18 years and above
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
Modified Vaccinia Virus Ankara vector expressing a stabilized SARS-CoV-2 spike protein
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04895449
|
https://clinicaltrials.gov/ct2/show/NCT04895449
|
NA
|
|
10290
|
AAV5-RBD-S
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Biocad
|
2021
|
Russia
|
18 - 60 years
|
NA
|
Intramuscular
|
NA
|
SARS-CoV-2 receptor-binding domain from spike protein
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT05037188
|
https://clinicaltrials.gov/ct2/show/NCT05037188
|
NA
|
|
10291
|
AdCLD-CoV19
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Cellid Co. Ltd.
|
2021
|
South Korea
|
19 - 64 years
|
Single dose
|
Intramuscular
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04666012
|
https://clinicaltrials.gov/ct2/show/NCT04666012
|
NA
|
|
10294
|
cAd3-EBO
|
Ebola
|
Hemorrhagic
|
Zaire ebolavirus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Centre Hospitalier Universitaire Vaudois
|
2014
|
Switzerland
|
18 - 65 years
|
NA
|
Intramuscular
|
NA
|
Zaire Ebola virus glycoprotein
|
Chimpanzee Adenovirus Vector expressing Zaire strain glycoprotein
|
NA
|
NA
|
NA
|
NA
|
27764560
|
NCT02289027
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287303/
|
NA
|
|
10296
|
rHEV
|
Hepatitis E
|
Hepatitic
|
Hepatitis E virus
|
double stranded DNA
|
Recombinant viral vector
|
Phase 2
|
GlaxoSmithKline
|
2011
|
USA
|
18 - 58 years
|
3 doses at regimen of 0, 1, and 6 months
|
NA
|
Aluminum (alum)
|
Capsid Protein ORF2
|
NA
|
NA
|
National Institute of Health, Novavax
|
NA
|
NA
|
NA
|
NA
|
https://www.who.int/immunization/sage/meetings/2014/october/4_Hepatitis_E_vaccine_pipeline_final_29_Sept_14.pdf
|
NA
|
|
10305
|
MV/Schwarz
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10308
|
MVA-mBN85B
|
Measles
|
Exanthous
|
Morbillivirus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 2
|
Bavarian Nordic
|
2012
|
South Africa
|
6 months - 6 years
|
2 doses 4 weeks apart
|
Subcutaneous
|
NA
|
Attenuated Modified Vaccinia Virus Ankara, strain encoding hemagglutinin protein, fusion protein and nucleoprotein of measles virus
|
NA
|
NA
|
NA
|
NA
|
Rouvax
|
NA
|
NCT00891007
|
https://clinicaltrials.gov/ct2/show/NCT00891007?recrs=abde&cond=measles+vaccines&phase=123&draw=2&rank=3
|
NA
|
|
10322
|
Convidecia
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 3
|
CanSino Biologics Inc.
|
NA
|
China
|
NA
|
Single dose
|
Intramuscular
|
NA
|
NA
|
NA
|
NA
|
Beijing Institute of Biotechnology
|
NA
|
Adenovirus type 5 vector
|
33816047
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10328
|
BriLife
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 3
|
Israel Institute for Biological Research
|
2021
|
Israel
|
18 - 55 years
|
NA
|
Intramuscular
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
Weizmann Institute of Science
|
NA
|
IIBR-100
|
33937326
|
NCT04990466
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082173/
|
NA
|
|
10329
|
GRAd-COV2
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 3
|
ReiThera Srl
|
2021
|
Italy
|
18 years and above
|
2 doses 21 days apart
|
Intramuscular
|
Replication defective Simian Adenovirus (GRAd) encoding S
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
NA
|
33816047
|
NCT04791423
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10336
|
Covishield
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 3
|
AstraZeneca plc
|
2021
|
Brazil
|
18 years and above
|
2 doses 28 days apart
|
Intramuscular
|
NA
|
SARS-CoV-2 variant strain B.1.351
|
NA
|
NA
|
NA
|
Brazil, UK, South Africa
|
AZD1222,ChAdOx1 nCoV-19, ChAdOx1-S, COVID-19 Vaccine AstraZeneca, AstraZeneca COVID-19 Vaccine, AZD2816,Vaxzevria
|
NA
|
NCT04973449
|
https://clinicaltrials.gov/ct2/show/NCT04973449
|
NA
|
|
10361
|
Ad26. RSV. preF
|
Respiratory syncytial virus infection
|
Respiratory
|
Respiratory syncytial virus
|
negative-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 3
|
Janssen Pharmaceutical
|
2021
|
USA
|
18 - 59 years
|
2 doses 6 months apart
|
Intramuscular
|
NA
|
Fusion glycoprotein of RSV
|
NA
|
US FDA
|
NA
|
NA
|
NA
|
NA
|
NCT05070546
|
https://clinicaltrials.gov/ct2/show/NCT05070546?recrs=bde&cond=Respiratory+Syncytial+Virus+%28RSV%29&phase=23&draw=2&rank=8
|
https://www.fda.gov/media/105619/download
|
|
10394
|
CAdVax-CHIK
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
GenPhar Inc.
|
NA
|
NA
|
NA
|
Single dose
|
NA
|
NA
|
CHIKV structural proteins
|
Produced in HEK293 packaging cell line
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://academic.oup.com/jid/article/214/suppl_5/S488/2632628
|
https://www.sciencedirect.com/science/article/pii/S0264410X16300731
|
|
10395
|
MVA-CHIKV
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
Single dose
|
NA
|
NA
|
CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://academic.oup.com/jid/article/214/suppl_5/S488/2632628
|
NA
|
|
10402
|
VSVdelG-CHIKV
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
Glycoprotein-deficient VSV encoding CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10403
|
VEE/CHIKV
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
Chimera consisting of VEEV nsP and CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
VEE/IRES-C/CHIKV
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10404
|
EILV/CHIKV
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
Eilat virus nonstructural and CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10405
|
CAdVax-CHIK
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
Replication-deficient Ad5 encoding CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10406
|
MVA-6KE1E3E2
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
MVA encoding CHIKV structural proteins
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10407
|
MVA-E2E3
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
CHIKV envelope protein (E2, E3)
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|
|
10408
|
MVA-CHIKV
|
Chikungunya fever
|
Exanthous
|
Chikungunya virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Preclinical
|
NA
|
NA
|
NA
|
NA
|
NA
|
Intraperitoneal
|
NA
|
CHIKV structural proteins (C, E3, E2, 6K, E1) into MVA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://link.springer.com/chapter/10.1007/82_2019_175
|
NA
|