ViralVacDB | Details of Viral Vaccine

Hepatitis E

Hepatitis E is an inflammation of the liver caused by infection with the hepatitis E virus (HEV).Every year there are an estimated 20 million HEV infections worldwide, leading to an estimated 3.3 million symptomatic cases of hepatitis E. WHO estimates that hepatitis E caused approximately 44 000 deaths in 2015 (accounting for 3.3% of the mortality due to viral hepatitis). The virus is transmitted via the fecal-oral route, principally via contaminated water. Hepatitis E is found worldwide, but the disease is most common in East and South Asia. A vaccine to prevent hepatitis E virus infection has been developed and is licensed in China
Detailed Information
Disease Name Hepatitis E
Virus Name Hepatitis E virus (HEV)
Capsid Symmetry Spherical
Capsid Naked/Enveloped Naked
Family Hepevirus
Genus Orthohepevirus
Genome Single-stranded, positive-sense RNA
Proteome Three open reading frames (ORFs): ORF1 encodes a nonstructural polyprotein for virus replication and transcription, ORF2 encodes the capsid protein that elicits neutralizing antibodies, and ORF3, which partially overlaps ORF2, encodes a multifunctional protein involved in virion morphogenesis and pathogenesis
Antigenic Target Capsid protein pORF2
Incubation Period 2 to 10 weeks, with an average of 5 to 6 weeks
Zoonotic Evidence Zoonosis
Host Human, pig, monkeys, some rodents, chicken
Chronology_Time 1955
Regions Affected East and South Asia.
Susceptible Age Group People aged 15–44 years
Transmission Route Fecal-oral transmission
Symptoms Symptoms include jaundice, lack of appetite and nausea. In rare cases, it may progress to acute liver failure
Genome Reference Genome Link
Proteome Reference Proteome Link
Reference Reference