Rotavirus Infection
Rotavirus is a very contagious virus that causes diarrhea. Before the development of a vaccine, most children had been infected with the virus at least once by age 5. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system.
| Detailed Information |
| Disease Name |
Rotavirus Infection |
| Virus Name |
Rotavirus |
| Capsid Symmetry |
Icosahedral |
| Capsid Naked/Enveloped |
Naked |
| Family |
Reoviridae |
| Genus |
Rotavirus |
| Genome |
Double stranded RNA |
| Proteome |
16 non-structural, 9 accessory and 4 structural proteins |
| Antigenic Target |
Proteins VP4 (P) and VP7 (G) ; GxPy strain, serotypes G1-4 |
| Incubation Period |
2 days |
| Zoonotic Evidence |
No |
| Host |
Human |
| Chronology_Time |
1986 |
| Regions Affected |
Worldwide |
| Susceptible Age Group |
Children under five years of age, especially those between 6 months and two years |
| Transmission Route |
Fecal-oral contact |
| Symptoms |
Nausea, feverwatery diarrhea and vomiting |
| Co-infection |
HIV |
| Genome Reference |
Genome Link |
| Proteome Reference |
Proteome Link |
| References |
Reference 1 |