|
10138
|
RotaTeq (RV5)
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Approved
|
Merck & Co. Inc.
|
NA
|
USA
|
6 months - 8 months
|
3 doses at age of 2 months, 4 months, and 6 months
|
Oral
|
NA
|
5 human-bovine reassortant rotaviruses (G1, G2, G3 G4, P[8])
|
NA
|
US FDA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.cdc.gov/vaccines/vpd/rotavirus/index.html
|
https://www.fda.gov/media/75718/download
|
|
10139
|
Rotarix (RV1)
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Approved
|
GlaxoSmithKline
|
2006
|
UK
|
6 months - 8 months
|
2 doses at ages 2 months and 4 months
|
Oral
|
NA
|
Human rotavirus strain (G1P[8])
|
NA
|
US FDA, EMA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.cdc.gov/vaccines/vpd/rotavirus/index.html
|
https://www.fda.gov/vaccines-blood-biologics/vaccines/rotarix
|
|
10140
|
Rotavac
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Approved
|
Bharat Biotech International Limited
|
2013
|
India
|
6 months - 8 months
|
3 doses 4 weeks apart
|
Oral
|
NA
|
Rotavirus 116E strain
|
NA
|
US FDA, Government of India
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.who.int/immunization/research/meetings_workshops/11_Cassels_Rotavirus_PDVAC_2019.pdf?ua=1
|
https://www.fda.gov/vaccines-blood-biologics/vaccines/rotavirus-vaccine-live-oral
|
|
10141
|
RotaSiil
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Approved
|
Serum Institute of India
|
2017
|
India
|
6 months - 8 months
|
3 doses 4 weeks apart
|
Oral
|
NA
|
Human-bovine reassortant rotaviruses (G1, G2, G3, G4, G9)
|
NA
|
National Institute of Health, Government of India
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.who.int/immunization/research/meetings_workshops/11_Cassels_Rotavirus_PDVAC_2019.pdf?ua=1
|
https://www.fda.gov/vaccines-blood-biologics/vaccines/rotarix
|
|
10142
|
BL 125296
|
Adenovirus Infection
|
Respiratory
|
Adenovirus Type 4, Type 7
|
double stranded DNA
|
Live-attenuated
|
Approved
|
Barr Pharmaceuticals Inc.
|
NA
|
USA
|
17 - 50 years
|
2 doses
|
Oral
|
NA
|
Live adenovirus
|
NA
|
US FDA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.fda.gov/media/80211/download
|
https://www.fda.gov/vaccines-blood-biologics/vaccines/adenovirus-type-4-and-type-7-vaccine-live-oral
|
|
10152
|
bacTRL-Spike vaccine
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
DNA based vaccine
|
Phase 1
|
Symvivo Corporation
|
NA
|
NA
|
18 - 59 years
|
NA
|
Oral
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
NA
|
32585611
|
NCT04334980
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301105/
|
NA
|
|
10156
|
VXA-CoV2-1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Vaxart
|
2021
|
USA
|
18 - 55 years
|
2 doses 28 days apart
|
Oral
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
NA
|
33937326
|
NCT04563702
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082173/
|
NA
|
|
10157
|
VXA-CoV2-1
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Recombinant viral vector
|
Phase 1
|
Vaxart
|
2021
|
USA
|
18 - 54 years
|
2 doses 28 days apart
|
Oral
|
NA
|
NA
|
Ad5 adjuvanted Oral Vaccine platform
|
NA
|
NA
|
NA
|
NA
|
33816047
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10164
|
bacTRL-Spike vaccine
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
DNA based vaccine
|
Phase 1
|
Symvivo Corporation
|
NA
|
NA
|
NA
|
Single dose
|
Oral
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
33816047
|
NA
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003899/
|
NA
|
|
10186
|
bacTRL-Spike vaccine
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
DNA based vaccine
|
Phase 1
|
Symvivo Corporation
|
2020
|
Australia
|
18 years and above
|
NA
|
Oral
|
NA
|
Spike protein of SARS-CoV-2 virus
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04334980
|
https://clinicaltrials.gov/show/NCT04334980
|
NA
|
|
10286
|
V-SARS
|
COVID-19
|
Respiratory
|
SARS-CoV-2 virus
|
positive-sense, single-stranded RNA
|
Plasma based
|
Phase 2
|
Immunitor LLC
|
2020
|
Canada
|
18 - 65 years
|
NA
|
Oral
|
NA
|
Pooled plasma of COVID-19 patients
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NCT04380532
|
https://clinicaltrials.gov/show/NCT04380532
|
NA
|
|
10312
|
RV3-BB
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Phase 2
|
PT Biofarma
|
NA
|
Indonesia
|
0 - 5 days
|
3 doses regimen child schedule (0 to 5 days, 8 weeks, and 14 weeks of age or an infant schedule (8 weeks, 14 weeks, and 18 weeks of age)
|
Oral
|
NA
|
Three VP8 subunit proteins expressing P[4], P[6] and P[8] serotypes
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://preventrotavirus.org/wp-content/uploads/2019/05/ROTA-Brief2-ProductLandscape-SP-1-3.pdf
|
NA
|
|
10377
|
Lamb rotavirus
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Phase 4
|
Lanzhou Biologicals
|
2000
|
China
|
6 months - 35 months
|
NA
|
Oral
|
NA
|
Single strain of rotavirus found in lamb (G10P)
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.who.int/immunization/research/meetings_workshops/11_Cassels_Rotavirus_PDVAC_2019.pdf?ua=1
|
https://preventrotavirus.org/wp-content/uploads/2019/05/ROTA-Brief2-ProductLandscape-SP-1-3.pdf
|
|
10378
|
ROTAVIN-M1
|
Rotavirus Infection
|
Gastrointestinal
|
Rotavirus
|
double stranded RNA
|
Live-attenuated
|
Phase 4
|
Polyvac, Center for Research and Production of Vaccines
|
NA
|
Vietnam
|
6 months - 8 months
|
NA
|
Oral
|
NA
|
Human rotavirus strain (G1P)
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
https://www.who.int/immunization/research/meetings_workshops/11_Cassels_Rotavirus_PDVAC_2019.pdf?ua=1
|
https://preventrotavirus.org/wp-content/uploads/2019/05/ROTA-Brief2-ProductLandscape-SP-1-3.pdf
|