ID |
Reference |
Source Clone name |
Sequence |
Motif |
Target-tumor |
Target-cell |
Receptors-biomarker |
Phage/Library |
In vitro/Ex-vivo |
In vivo |
Homing/targeting |
Payloads |
patent |
1176 | Joyce JA et al. Cancer Cell. 2003 Nov;4(5):393-403. | RGR | CRGRRST | RGRRS, RGRR | Pancreatic islet carcinoma | Endothelial cellor pericytes | NA | T7 phage/CX7C peptide library | NA | Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice | Homing | NA | WO05041882A2,US20050245445A1 |
1177 | Joyce JA et al. Cancer Cell. 2003 Nov;4(5):393-403. | RSR | CRSRKG | CRSR-GCRSR-G | Pancreatic islet carcinoma | Endothelial cellor pericytes | NA | T7 phage/CX7C peptide library | NA | Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice | Homing | NA | US 2005/0245445A1 |
1178 | Joyce JA et al. Cancer Cell. 2003 Nov;4(5):393-403. | KAA | CKAAKNK | CKA-K | Pancreatic islet carcinoma | Endothelial cellor pericytes | NA | T7 phage/CX7C peptide library | NA | Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice | Homing | NA | US 2005/0245445A1 |
1179 | Joyce JA et al. Cancer Cell. 2003 Nov;4(5):393-403. | KAR | CKGAKAR | CKGAKA, AKAR, GAKAR | Pancreatic islet carcinoma | Endothelial cellor pericytes | NA | T7 phage/CX7C peptide library | NA | Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice | Homing | NA | US 2010/0076175A1 |
1180 | Joyce JA et al. Cancer Cell. 2003 Nov;4(5):393-403. | VGVA | FRVGVADV | F-VGVADV, RVGV | Pancreatic islet carcinoma | Endothelial cellor pericytes | NA | T7 phage/CX7C peptide library | NA | Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice | Homing | NA | US 2005/0245445A1 |
1181 | Joyce JA et al. Cancer Cell. 2003 Nov;4(5):393-403. | EYQ | CEYQLDVE | CEYQL, YQLDV, YQLDV | Pancreatic islet carcinoma | Endothelial cellor pericytes | NA | T7 phage/CX7C peptide library | NA | Prototypical mouse model of multistage tumorigenesis, RIP1-Tag2 transgenic model of islet cell carcinoma and K14-HPV16 mice | Homing | NA | US 2005/0245445 A1 |
1190 | Rafii S et al. Cancer Cell. 2003 Nov;4(5):331-3. | NA | CRSRKG | NA | Pancreatic tumor | Tumor vessel | NA | T7 phage /9-mer cyclic (CX7C) peptide library | NA | RIP-Tag2 pancreatic tumors in murine model | Homing | NA | US 7,598,341 B2 |
1191 | Rafii S et al. Cancer Cell. 2003 Nov;4(5):331-3. | NA | CEYQLDVE | NA | Pancreatic tumor | Tumor vessel | NA | T7 phage /9-mer cyclic (CX7C) peptide library | NA | RIP-Tag2 pancreatic tumors in murine model | Homing | NA | US 7,598,341 B2 |
1226 | Oku N et al. Oncogene. 2002 Apr 18;21(17):2662-9. | NA | PRPGAPLAGSWPGTS | PRP | Melanoma, Pancreatic, Brain cancer | Angiogenic endothelial cell | VEGF | M13 phage/15 mer peptide library | Human tumor tissues of islet cells of pancreas, glioblastoma of brain. | 5-week-old C57BL/6 male bearing B16BL6 melanoma cells | Homing | Radionuclide PRP-Lip -Andramycin drug | EP1122262A4 |
1258 | Aoki Y et al. Cancer Gene Ther. 2001 Oct;8(10):783-7. | NA | CRGDCF | RGD | Hepatic and pancreatic cancer | Tumor cell | Integrins | NA | Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 ) | Male BALB /c mice | Homing | Histidylated oligolysine plasmid , bafliomycin | NA |
1259 | Aoki Y et al. Cancer Gene Ther. 2001 Oct;8(10):783-7. | NA | CDCRGDCFC | RGD | Hepatic and pancreatic cancer | Tumor cell | Integrins | NA | Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 ) | NA | Targeting | NA | US 2003/0152578 A1 |
1260 | Aoki Y et al. Cancer Gene Ther. 2001 Oct;8(10):783-7. | NA | CNGRCVSGCAGRC | NGR | Hepatic and pancreatic cancer | Tumor cell | Integrins | NA | Human hepatoma cell lines ( PLC / PRF / 5 andHepG2 ) ,human pancreatic cancer cell lines ( Hs700T and MIAPaCa - 2 ) | NA | Targeting | NA | WO06067633A2 |
1328 | Sugahara KN et al. Cancer Cell. 2009 Dec 8;16(6):510-20. | NA | CRGDKGPDC | RGD | Prostate, Pancreatic ductal, breast cancer, bone , brain, cervical cancer | Endothelial cell and tumor cell | Alpha 5 beta 3 and Alpha 5 beta 5 integrins neuropilin-1 | T7 phage / CX7C peptide library | Cultured PPC1 human prostate cancer cells, M21 human melanoma cells | Nude mice with multiple tumors (prostrate PC-3, PPC1, 22RVI Xenograft), (pancreatic MIAPaCa-2 Xenograft) | Homing | Iron oxide nanoworms, iRGD-linked abraxane | US 2009/0246133A1 |
1468 | Yao VJ et al. Am J Pathol. 2005 Feb;166(2):625-36. | NA | CVSNPRWKC | NA | Pancreatic islet tumors | Tumor vessel | EphA4, a receptor for epinephrine-A | Phage/ CX7C peptide library | EphA2-Fc protein and to the EphA2 receptor expressed on human umbilical vein endothelial cells , MDA-MB-435 cultured human breast carcinoma cells | Male C57BL/6/RIP-Tag2 transgenic mice | Homing | NA | NA |
1469 | Yao VJ et al. Am J Pathol. 2005 Feb;166(2):625-36. | NA | CHVLWSTRC | NA | Pancreatic islet tumors | Tumor vessel | EphA4, a receptor for epinephrine-A | Phage/ CX7C peptide library | EphA2-Fc protein and to the EphA2 receptor expressed on human umbilical vein endothelial cells , MDA-MB-435 cultured human breast carcinoma cells | Male C57BL/6/RIP-Tag2 transgenic mice | Targeting | NA | NA |
1470 | Yao VJ et al. Am J Pathol. 2005 Feb;166(2):625-36. | NA | SWLAYPGAVSYR | NA | Pancreatic islet tumors | Tumor vessel | Epinephrine-A | Phage/ CX7C peptide library | EphA2-Fc protein and to the EphA2 receptor expressed on human umbilical vein endothelial cells , MDA-MB-435 cultured human breast carcinoma cells | Male C57BL/6/RIP-Tag2 transgenic mice | Targeting | NA | NA |
1471 | Yao VJ et al. Am J Pathol. 2005 Feb;166(2):625-36. | NA | YSAYPDSVPMMS | NA | Pancreatic islet tumors | Tumor vessel | Epinephrine-A | Phage/ CX7C peptide library | EphA2-Fc protein and to the EphA2 receptor expressed on human umbilical vein endothelial cells , MDA-MB-435 cultured human breast carcinoma cells | Male C57BL/6/RIP-Tag2 transgenic mice | Targeting | NA | NA |