Detailed description page of ThPDB2

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Th1160 details
Primary information
ID10701
Therapeutic IDTh1160
Protein NameSatumomab Pendetide
Sequence>Th1160_Satumomab_Pendetide QVQLQQSDAELVKPGASVKISCKASGYTFTDHAIHWAKQKPEQGLEWIGYISPGNDDIKYNEKFKGKATLTADKSSSTAYMQLNSLTSEDSAVYFCKRSYYGHWGQGTTLTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSR
Molecular Weight141478.9
Chemical FormulaC6268H9708N1666O1971S48
Isoelectric Point7.02
Hydrophobicity-0.427
Melting point61 (FAB fr
Half-life0.80 hours(Mammalian reticulocytes)
DescriptionTumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint) is no longer commercially available.
Indication/DiseaseFor diagnosis of extrahepatic malignant cancers
PharmacodynamicsBinds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors
Mechanism of ActionSatumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
ToxicityNA
MetabolismNA
AbsorptionNA
NA
ClearanceNA
CategoriesDiagnostic Agents
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetTumor-associated glycoprotein 72 (TAG-72)
Brand NameOncoScint
CompanyCytogen Corp, Lonza Biologics
Brand DescriptionCytogen Corp, Lonza Biologics
Prescribed ForExtrahepatic malignant disease (diagnosis)—Indium In 111 satumomab pendetide is indicated for use in immunoscintigraphy in patients with known colorectal or ovarian cancer.
Chemical NameNA
FormulationNA
Physical Appearance NA
Route of AdministrationIntravenous Injection
Recommended DosageEstimated dose- 0.32 mSv/MBq
ContraindicationNA
Side EffectsChillls, Diarrhea, Dizziness, Flushing of Skin, Allergic reactions, confusion, hypertension, Skin rashes, hypothermia, nausea, headache.
Useful Link 1Link
Useful Link 2NA
RemarksNA