Detailed description page of ThPDB2

This page displays user query in tabular form.

Th1149 details
Primary information
ID10681
Therapeutic IDTh1149
Protein NameRagweed Pollen Extract
SequenceNA
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting pointNA
Half-lifeNA
DescriptionRagweed pollen extract has been developed by Curalogic. The company has initiated a phase III trial with its product for oral immunotherapy of ragweed allergy. While traditional disease-modifying immunotherapeutics are administered by subcutaneous injection, Curalogic has developed a more convenient orally administered drug.
Indication/DiseaseInvestigated for use/treatment in allergic reaction.
PharmacodynamicsPrecise mechanism of allergen immunotherapy is not known
Mechanism of ActionRagweed pollen extract is the oral immunotherapy delivered via microencapsulated beads put into a capsule, which enables the antigen to be delivered more efficiently to the Peyer's patches in the jejunum and duodenum, where the antigen can be presented and processed and not destroyed by stomach acid.
ToxicityNA
MetabolismNA
AbsorptionNA
NA
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Brand NameRagwitek
CompanyMerck Sharp & Dohme
Brand DescriptionMerck Sharp & Dohme
Prescribed ForRagwitek is an allergen extract indicated as immunotherapy for the treatment of short ragweed pollen-induced allergic rhinitis, with or withoutconjunctivitis, confirmed by positive skin test or in vitro testing for pollen-specific IgE antibodies for short ragweed pollen. Ragwitek is approved for use in adults 18 through 65 years of age.
Chemical NameNA
FormulationNA
Physical Appearance Tablets
Route of AdministrationOral route
Recommended DosageOne ragwitek tablet daily.
ContraindicationRagwitek is contraindicated in patients with severe, unstable or uncontrolled asthma, history of any severe systemic allergic reaction, history of any severe local reaction after taking any sublingual allergen immunotherapy, history of eosinophilic esophagitis and hypersensitivity to any of the inactive ingredients [gelatin, mannitol, and sodium hydroxide] contained in this product.
Side EffectsThroat irritation, oralpruritus, ear pruritus, oral paraesthesia, mouth edema, and tongue pruritus.
Useful Link 1Link
Useful Link 2NA
RemarksNA