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Th1011 details
Primary information
ID10064
Therapeutic IDTh1011
Protein NameDarbepoetin alfa
Sequence>Th1011_Darbepoetin_alfa MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCNETCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQVNETLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
Molecular Weight18396.1
Chemical FormulaC815H1317N233O241S5
Isoelectric Point8.75
Hydrophobicity-0.188
Melting point53
Half-lifeNA
DescriptionHuman erythropoietin with 2 amino acid substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW 37kD) produced in CHO cells by recombinant DNA technology.
Indication/DiseaseFor treating anemia (from renal transplants or certain HIV treatment).
PharmacodynamicsDarbepoetin alfa is used in treating anemia. It is involved in the regulation of erythrocyte differentiation and maintenance of a physiological level of circulating erythrocyte mass.
Mechanism of ActionDarbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin, it interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization.
ToxicityNA
MetabolismNA
AbsorptionNA
NA
ClearanceNA
CategoriesAmino Acids, Peptides, and Proteins, Antianemic Preparations, Blood and Blood Forming Organs, Colony-Stimulating Factors, Erythropoiesis-Stimulating Agents, Glycoproteins, Hematinics, Hematologic Agents, Hematopoietic Cell Growth Factors, Increased Erythroid Cell Production, Proteins
Patents NumberCA2165694
Date of Issue18-Mar-2003
Date of Expiry15-Oct-2010
Drug InteractionNA
TargetErythropoietin receptor
Brand NameAranesp
CompanyAmgen Inc
Brand DescriptionAmgen Inc
Prescribed ForUsed to treat anemia.
Chemical NameNA
FormulationEach 1 mL contains polysorbate 80 (0.05 mg), sodium chloride (8.18 mg), sodium phosphate dibasic anhydrous (0.66 mg), and sodium phosphate monobasic monohydrate (2.12 mg) in Water for Injection, USP (pH 6.2 ± 0.2).
Physical Appearance Sterile, colorless, preservative-free solution containing polysorbate
Route of AdministrationIntravenous or Subcutaneous administration
Recommended DosageNA
ContraindicationAllergic
Side EffectsFever, chills, body aches, flu symptoms; feeling like you might pass out; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; seizure (black-out or convulsions); or dangerously high blood pressure.
Useful Link 1Link
Useful Link 2NA
RemarksNA


Primary information
ID10065
Therapeutic IDTh1011
Protein NameDarbepoetin alfa
Sequence>Th1011_Darbepoetin_alfa MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCNETCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQVNETLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
Molecular Weight18396.1
Chemical FormulaC815H1317N233O241S5
Isoelectric Point8.75
Hydrophobicity-0.188
Melting point53
Half-lifeNA
DescriptionHuman erythropoietin with 2 amino acid substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW 37kD) produced in CHO cells by recombinant DNA technology.
Indication/DiseaseFor treating anemia (from renal transplants or certain HIV treatment).
PharmacodynamicsDarbepoetin alfa is used in treating anemia. It is involved in the regulation of erythrocyte differentiation and maintenance of a physiological level of circulating erythrocyte mass.
Mechanism of ActionDarbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin, it interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization.
ToxicityNA
MetabolismNA
AbsorptionNA
NA
ClearanceNA
CategoriesAmino Acids, Peptides, and Proteins, Antianemic Preparations, Blood and Blood Forming Organs, Colony-Stimulating Factors, Erythropoiesis-Stimulating Agents, Glycoproteins, Hematinics, Hematologic Agents, Hematopoietic Cell Growth Factors, Increased Erythroid Cell Production, Proteins
Patents NumberCA2147124
Date of Issue5-Nov-2002
Date of Expiry16-Aug-2014
Drug InteractionNA
TargetNA
Brand NameNA
CompanyPhysicians Total Care Inc.
Brand DescriptionPhysicians Total Care Inc.
Prescribed ForNA
Chemical NameNA
FormulationNA
Physical Appearance NA
Route of AdministrationNA
Recommended DosageNA
ContraindicationUntreated or uncontrolled high blood pressure or have ever had pure red cell aplasia caused by using darbepoetin alfa or epoetin alfa.
Side EffectsSevere headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure, stomach pain; mild cough; mild skin rash or redness; or pain, bruising, swelling, warmth, redness, oozing, or bleeding.
Useful Link 1Link
Useful Link 2NA
RemarksNA


Primary information
ID10066
Therapeutic IDTh1011
Protein NameDarbepoetin alfa
Sequence>Th1011_Darbepoetin_alfa MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCNETCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQVNETLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
Molecular Weight18396.1
Chemical FormulaC815H1317N233O241S5
Isoelectric Point8.75
Hydrophobicity-0.188
Melting point53
Half-lifeNA
DescriptionHuman erythropoietin with 2 amino acid substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW 37kD) produced in CHO cells by recombinant DNA technology.
Indication/DiseaseFor treating anemia (from renal transplants or certain HIV treatment).
PharmacodynamicsDarbepoetin alfa is used in treating anemia. It is involved in the regulation of erythrocyte differentiation and maintenance of a physiological level of circulating erythrocyte mass.
Mechanism of ActionDarbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin, it interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization.
ToxicityNA
MetabolismNA
AbsorptionNA
NA
ClearanceNA
CategoriesAmino Acids, Peptides, and Proteins, Antianemic Preparations, Blood and Blood Forming Organs, Colony-Stimulating Factors, Erythropoiesis-Stimulating Agents, Glycoproteins, Hematinics, Hematologic Agents, Hematopoietic Cell Growth Factors, Increased Erythroid Cell Production, Proteins
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionNA
TargetNA
Brand NameNA
CompanyNA
Brand DescriptionNA
Prescribed ForNA
Chemical NameNA
FormulationNA
Physical Appearance NA
Route of AdministrationNA
Recommended DosageNA
ContraindicationNA
Side EffectsNA
Useful Link 1Link
Useful Link 2NA
RemarksNA