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| Primary information |
|---|
| ID | 10842 |
| Therapeutic ID | Th1205 |
| Protein Name | Obiltoxaximab |
| Sequence | NA
|
| Molecular Weight | 148000 |
| Chemical Formula | NA |
| Isoelectric Point | NA |
| Hydrophobicity | NA |
| Melting point | NA |
| Half-life | NA |
| Description | Obiltoxaximab, an affinity-enhanced monoclonal antibody (Mab), is used for prevention and treatment of infection and death caused by anthrax toxin. Obiltoxaximab is a chimeric IgG1 kappa monoclonal antibody (mAb) that binds the PA component of B. anthracis toxin. It has an approximate molecular weight of 148 kDa. |
| Indication/Disease | Investigated for use/treatment in anthrax exposure, bacterial infection, crohn's disease, and graft versus host disease. |
| Pharmacodynamics | NA |
| Mechanism of Action | ETI-204 is an affinity-enhanced, de-immunized antibody, which means that its ability to bind to its target pathogen has been strengthened and that elements that might cause an immune response have been removed. ETI-204 targets and binds to Protective Antigen, which prevents the anthrax toxins from binding to and entering the cells in the body, thereby preventing death. |
| Toxicity | NA |
| Metabolism | NA |
| Absorption | NA |
| NA |
| Clearance | NA |
| Categories | Amino Acids, Peptides, and Proteins,Anthrax Protective Antigen-directed Antibody,Anthrax Protective Antigen-directed Antibody Interactions,Antibodies,Antiinfectives for Systemic Use,Biological Products,Blood,Blood Proteins,Body Fluids,Complex Mixtures,Fluids and Secretions,Globulins,Hemic and Immune Systems,Immune Sera,Immune Sera and Immunoglobulins,Immunoglobulins,Immunoproteins,Proteins,Serum,Serum Globulins,Specific Immunoglobulins |
| Patents Number | NA |
| Date of Issue | NA |
| Date of Expiry | NA |
| Drug Interaction | NA |
| Target | NA |
| Brand Name | Anthim |
| Company | Elusys Therapeutics, Inc. |
| Brand Description | Elusys Therapeutics, Inc. |
| Prescribed For | ANTHIM is indicated in adult and pediatric patients for the treatment of inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs.; Also is indicated for prophylaxis of inhalational anthrax due to B. anthracis when alternative therapies are not available or not appropriate. |
| Chemical Name | NA |
| Formulation | Solution |
| Physical Appearance | Liquid |
| Route of Administration | Intravenous infusion |
| Recommended Dosage | The recommended dosage of ANTHIM in adult patients is a single dose of 16 mg/kg administered intravenously over 90 minutes (1 hour and 30 minutes); For adult patients weighing less than 40 kg. |
| Contraindication | NA |
| Side Effects | Hypersensitivity and Anaphylaxis |
| Useful Link 1 | Link |
| Useful Link 2 | NA |
| Remarks | NA |