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10799 details
Primary information
ID10799
Therapeutic IDTh1186
Protein NameHuman rabies virus immune globulin
SequenceNA
Molecular WeightNA
Chemical FormulaNA
Isoelectric PointNA
HydrophobicityNA
Melting pointNA
Half-lifeNA
DescriptionNA
Indication/DiseaseIt is indicated for individuals suspected of exposure to rabies, particularly severe exposure, with one exception: persons who have been previously immunized with HDCV Rabies Vaccine in a pre-exposure or postexposure treatment series should receive only vaccine.
PharmacodynamicsNA
Mechanism of ActionIt provides passive protection by neutralizing the rabies virus when given to individuals exposed to rabies virus. When a rabies immune globulin dose of 20 IU/kg was given simultaneously with the first dose of rabies vaccine, levels of passive anti-rabies antibody were detected 24 hours after injection in all individuals. There was minimal or no interference with the immune response to the initial and subsequent doses of rabies vaccine, including booster doses.
ToxicityNA
MetabolismNA
AbsorptionNA
NA
ClearanceNA
CategoriesNA
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionLive virus vaccines, such as measles vaccine, should not be given for four months following Human rabies virus immune globulin administration because antibodies in the immune globulin preparation may interfere with the immune response to the vaccine.
TargetNA
Brand NameImogam Rabies Pasteurized
CompanySanofi Pasteur Limited
Brand DescriptionSanofi Pasteur Limited
Prescribed ForIt is indicated for post-exposure prophylaxis in persons suspected of exposure to rabies, who have not previously received a complete immunization regimen with a cell culture produced rabies vaccine.
Chemical NameNA
FormulationHuman proteins (100-160 mg) containing IgG-class human rabies immune globulins with a minimum titre of 150 IU/mL. Supplied in 2 mL vial s (300 IU) and 10 mL vials (1,500 IU).
Physical Appearance Solution
Route of Administrationintramuscular
Recommended DosageThe recommended dose of IMOGAM® Rabies Pasteurized is 20 IU/kg (0.133 mL/kg) of body weight at the time of administration of the first dose of rabies vaccine.
ContraindicationIMOGAM® Rabies Pasteurized should not be administered as repeat doses once rabies vaccination has been in itiated. Repeating the dose may interfere with maximum active immunity expected to develop from the rabies vaccine.
Side EffectsHypotension, Tachycardia, Nausea, Vomiting, Local reaction, Fever, chills, Allergic type reaction, Anaphylactic shock, General prurit, Rash
Useful Link 1Link
Useful Link 2NA
RemarksNA