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10366 details
Primary information
ID10366
Therapeutic IDTh1053
Protein NameSerum albumin iodonated
Sequence>Th1053_Serum_albumin_iodonated MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
Molecular Weight66472.2
Chemical FormulaC2936H4624N786O889S41
Isoelectric Point5.67
Hydrophobicity-0.395
Melting point62
Half-lifeNA
DescriptionA diagnostic radiopharmaceutical containing iodinated I 131 albumin for intravenous imaging. Following Intravenous infusion, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly (2 days). Indicated for use in determinations of total blood and plasma volumes, cardiac output, cardiac and pulmonary blood volumes and circulation times
Indication/DiseaseFor determination of total blood and plasma volumes
PharmacodynamicsRegulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.
Mechanism of ActionSerum albumin acts as a high molecular weight, very soluble osmolyte
ToxicityIn general, human albumin solutions are well-tolerated and no specific, clinically relevant alterations in organ function or coagulopathy have been substantiated. The most common adverse reactions are rigors, hypotension, tachycardia with increased heart rate, fever, chills, nausea, vomiting, dyspnea and/or bronchospasm, skin rash/pruritus. Stop the infusion immediately if anaphylaxis, with or without shock is observed. Hypervolemia may occur if the dosage and rate of infusion are not adjusted to the volume status of the patient. When clinical signs of cardiovascular overload occur (headache, dyspnea, jugular venous distention, increased blood pressure), the infusion must be slowed or stopped immediately.
MetabolismNA
AbsorptionNA
Albumin is distributed throughout the extracellular space and more than 60% of the body albumin pool is located in the extravascular fluid space . In healthy adults, less than 10% of infused albumin leaves the intravascular compartment during the first 2 hours following infusion of albumin. There is considerable individual variation in the effect of albumin on plasma volume, however. In some patients, the plasma volume can remain elevated for several hours. In critically ill patients, however, albumin can leak out of the vascular space in substantial amounts at an unpredictable rate that is difficult to predict.
ClearanceNA
CategoriesAlbumins, Amino Acids, Peptides, and Proteins, Blood and Blood Forming Organs, Blood and Related Products, Blood Derivatives, Blood Proteins, Blood Substitutes and Perfusion Solutions, Blood Substitutes and Plasma Protein Fractions, Cardiac Function, Diluents, Human Serum Albumin, Increased Intravascular Volume, Increased Oncotic Pressure, Osmotic Activity, Proteins, Serum Albumin
Patents NumberNA
Date of IssueNA
Date of ExpiryNA
Drug InteractionRilonacept results in increased immunosuppressive effects; increases the risk of infection
TargetNA
Brand NameJeanotope
CompanyIsoTex Diagnostics
Brand DescriptionIsoTex Diagnostics
Prescribed ForJeanotope I-125 is indicated for use in the determination of total blood and plasma volume.
Chemical NameNA
FormulationEach milliliter provides approximately 10 mg protein (normal human serum albumin), 1.6 mg sodium phosphate, 16 mg sodium biphosphate, not more than 0.4 mg guanidine hydrochloride, sodium chloride for isotonicity, and 9 mg benzyl alcohol as a preservative. The stabilizer aceryltryptophanate and sodium caprylate have a concentration of less, than 0.0089M.
Physical Appearance Jeanatope 1-125 (Iodinated 1-125 Albumin Injection) is a Sterile, nonpyrogenic, aqueos solution
Route of AdministrationIntravenous infusion
Recommended DosageWhen a procedure such as a blood volume determination is to be repeated, the total dosage administered in any one week should not exceed 7.4 megabecquerels, (200 microcuries).
ContraindicationAt present there are no known contraindications to the use of this preparation
Side EffectsAlthough the immunological properties of albumin human are believed to be virtually unaltered by the iodination process, there is a theoretical possibility that allergic reactions may occur in patients receiving additional doses a number of weeks after an initial dose.
Useful Link 1Link
Useful Link 2NA
RemarksNA