Primary information |
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PRRID | PRRID_0098 |
Ligand Name | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) |
Source | NA |
Sequence of ligand | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-, TNF, CCL2, and CXCL10 |
Name of receptor | TLR7 |
Type of receptor | TLR |
Source | Newborn Mice |
Localization | Astrocytes and microglia |
Domain | LRR |
Sequence of Receptor | P58681.fasta |
Swiss prot ID | P58681 |
Length Of Receptor | 1050 |
Function | It induces a neuroinflammatory response in CNS. |
Assay used | Cytokines assay |
PMID | 18490763 |
Year of Publication | 2008 |
Pubchem assay | NA |
Pdb | PRR_0098.pdb |
3-D Structure | PRR_0098 (View) or (Download) |