| Primary information |
|---|
| PRRID | PRRID_0058 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | Gram-negative bacteria |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | LPS |
| Occurence | Natural |
| Role of Ligand | induces a strong response from normal animal immune systems |
| Name of receptor | TLR4 |
| Type of receptor | TLR |
| Source | Guinea Pig |
| Localization | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte |
| Domain | cell surface |
| Sequence of Receptor | H0VSQ0.fasta |
| Swiss prot ID | H0VSQ0 |
| Length Of Receptor | 837 |
| Function | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system |
| Assay used | Real-time RT-PCR, Calcium influx assay |
| PMID | 24819048 |
| Year of Publication | 2014 |
| Pubchem assay | NA |
| Pdb | PRR_0058.pdb |
| 3-D Structure | PRR_0058 (View) or (Download) |