| Primary information |
|---|
| PRRID | PRRID_0057 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | Escherichia coli serotype 0127:B9 (Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | LPS |
| Occurence | Natural |
| Role of Ligand | Binding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes |
| Name of receptor | TLR4 |
| Type of receptor | TLR |
| Source | Wistar Rat |
| Localization | Pineal gland (pinealocytes) |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QX05.fasta |
| Swiss prot ID | Q9QX05 |
| Length Of Receptor | 835 |
| Function | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response |
| Assay used | EMSA |
| PMID | 20586888 |
| Year of Publication | 2010 |
| Pubchem assay | NA |
| Pdb | PRR_0057.pdb |
| 3-D Structure | PRR_0057 (View) or (Download) |