Detailed description page of PRRDB2.0

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PRRID_1580 details
Primary information
PRRIDPRRID_1580
Ligand Namepolyinosinic-polycytidylic acid [poly(I:C)]
SourceNA
Sequence of ligandC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of Ligandact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells
Name of receptorToll-like receptor 3 (TLR3)
Type of receptorToll-like receptor (TLR)
Source Mice
LocalizationDendritic Cell, B-lymphocyte
DomainCell Compartment/Intracellular (Endosome)
Sequence of ReceptorQ99MB1.fasta
Swiss prot IDQ99MB1
Length Of Receptor905
Functioninduce type I interferons (IFN) and other cytokines production.
Assay usedELISA
PMID24771854
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1580
Ligand Namepolyinosinic-polycytidylic acid [poly(I:C)]
SourceNA
Sequence of ligandC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of Ligandact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells
Name of receptorToll-like receptor 3 (TLR3)
Type of receptorToll-like receptor (TLR)
Source Mice
LocalizationDendritic Cell, B-lymphocyte
DomainCell Compartment/Intracellular (Endosome)
Sequence of ReceptorQ99MB1.fasta
Swiss prot IDQ99MB1
Length Of Receptor905
Functioninduce type I interferons (IFN) and other cytokines production.
Assay usedELISA
PMID24771854
Year of Publication2014
Pubchem assayPubchem_assay