Detailed description page of PRRDB2.0
| This page displays user query in tabular form. |
PRRID_1566 details |
| Primary information | |
|---|---|
| PRRID | PRRID_1566 |
| Ligand Name | phosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide) |
| Source | Bacteria |
| Sequence of ligand | NA |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | CpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human |
| Name of receptor | Toll-like receptor 9 (TLR9) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | B-Lymphocytes |
| Domain | Toll-IL-1R (TIR) domain |
| Sequence of Receptor | Q9NR96.fasta |
| Swiss prot ID | Q9NR96 |
| Length Of Receptor | 1032 |
| Function | induces pro-inflammatory cytokine response |
| Assay used | NA |
| PMID | 24801688 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |
| Primary information | |
|---|---|
| PRRID | PRRID_1566 |
| Ligand Name | phosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide) |
| Source | Bacteria |
| Sequence of ligand | NA |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | CpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human |
| Name of receptor | Toll-like receptor 9 (TLR9) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | B-Lymphocytes |
| Domain | Toll-IL-1R (TIR) domain |
| Sequence of Receptor | Q9NR96.fasta |
| Swiss prot ID | Q9NR96 |
| Length Of Receptor | 1032 |
| Function | induces pro-inflammatory cytokine response |
| Assay used | NA |
| PMID | 24801688 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |