Detailed description page of PRRDB2.0

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PRRID_1565 details
Primary information
PRRIDPRRID_1565
Ligand Namephosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide)
SourceBacteria
Sequence of ligandNA
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandCpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human
Name of receptorToll-like receptor 9 (TLR9)
Type of receptorToll-like receptor (TLR)
Source Mice
LocalizationB-Lymphocytes
DomainToll-IL-1R (TIR) domain
Sequence of ReceptorQ9NR96.fasta
Swiss prot IDQ9NR96
Length Of Receptor1032
Functioninduces pro-inflammatory cytokine response
Assay usedNA
PMID24801688
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1565
Ligand Namephosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide)
SourceBacteria
Sequence of ligandNA
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandCpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human
Name of receptorToll-like receptor 9 (TLR9)
Type of receptorToll-like receptor (TLR)
Source Mice
LocalizationB-Lymphocytes
DomainToll-IL-1R (TIR) domain
Sequence of ReceptorQ9NR96.fasta
Swiss prot IDQ9NR96
Length Of Receptor1032
Functioninduces pro-inflammatory cytokine response
Assay usedNA
PMID24801688
Year of Publication2014
Pubchem assayPubchem_assay