| Primary information |
|---|
| PRRID | PRRID_0846 |
| Ligand Name | Xanthine oxidase |
| Source | NA |
| Sequence of ligand | NA |
| Length | NA |
| Type | Endogenous |
| Occurence | Natural |
| Role of Ligand | xanthine oxidase can bind to TLR4 and that superoxide must be delivered by xanthine oxidase in close proximity to TLR4 in order to activate neutrophils |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | NA |
| Localization | neutrohils |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | This binding of Xanthine oxidase brings superoxides in close proximity to TLR4, which leads to production of proinflammatory cytokines in case of ischemia–reperfusion injury |
| Assay used | NA |
| PMID | 20689929 |
| Year of Publication | 2010 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_0846 |
| Ligand Name | Xanthine oxidase |
| Source | NA |
| Sequence of ligand | NA |
| Length | NA |
| Type | Endogenous |
| Occurence | Natural |
| Role of Ligand | xanthine oxidase can bind to TLR4 and that superoxide must be delivered by xanthine oxidase in close proximity to TLR4 in order to activate neutrophils |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | NA |
| Localization | neutrohils |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | This binding of Xanthine oxidase brings superoxides in close proximity to TLR4, which leads to production of proinflammatory cytokines in case of ischemia–reperfusion injury |
| Assay used | NA |
| PMID | 20689929 |
| Year of Publication | 2010 |
| Pubchem assay | NA |