Primary information |
---|
PRRID | PRRID_0755 |
Ligand Name | polyinosinic-polycytidylic acid [poly(I:C)] |
Source | NA |
Sequence of ligand | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | It results mTOR positively regulates interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNFα) and interferon beta (IFN-β) expression, but negatively regulates IL-12p70 expression in keratinocytes |
Name of receptor | Toll-like receptor 3 (TLR3) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | Keratinocytes |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | O15455.fasta |
Swiss prot ID | O15455 |
Length Of Receptor | 904 |
Function | It leads to the inflammatory response from the immune system leads to the clearance of pathogens |
Assay used | NA |
PMID | 20728939 |
Year of Publication | 2010 |
Pubchem assay | Pubchem Assay |
Primary information |
---|
PRRID | PRRID_0755 |
Ligand Name | polyinosinic-polycytidylic acid [poly(I:C)] |
Source | NA |
Sequence of ligand | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | It results mTOR positively regulates interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNFα) and interferon beta (IFN-β) expression, but negatively regulates IL-12p70 expression in keratinocytes |
Name of receptor | Toll-like receptor 3 (TLR3) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | Keratinocytes |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | O15455.fasta |
Swiss prot ID | O15455 |
Length Of Receptor | 904 |
Function | It leads to the inflammatory response from the immune system leads to the clearance of pathogens |
Assay used | NA |
PMID | 20728939 |
Year of Publication | 2010 |
Pubchem assay | Pubchem Assay |