This page lists the various C-terminal modifications, N-terminal modifications as well as the chemical modifications that were incorporated in the peptides compiled in PEPlife.
For more information see HELP page.
| C-terminal modifications | Number of entries |
|---|---|
| XTEN | 4 |
| Pegylation | 25 |
| Amidation | 603 |
| Addition of Fc | 14 |
| Addition of hydroxyl group | 17 |
| Biotinylation | 375 |
| Cholesterol moiety | 2 |
| Human serum albumin | 3 |
| NH-3,5-Bzl(CF3)2 | 4 |
| NH-[3’,5’-(CF3 )2 Bzl] | 5 |
| NHBn | 24 |
| O-[3’,5’-(CF3 )2 Bzl] | 1 |
| CH2CH2Ph | 15 |
| N-terminal modifications | Number of entries |
|---|---|
| Acylation | 195 |
| Glycosylation | 7 |
| Succinylation | 5 |
| Human serum albumin | 3 |
| Human transferrin protein | 1 |
| Hydroxylation | 16 |
| Pegylation | 40 |
| 2,4-dichlorophenoxyacetic acid with (CH2)n-spacers | 375 |
| Non-Terminal Modification | Number of entries |
|---|---|
| Pegylation | 25 |
| Abu=2-aminobutyric acid | 2 |
| 2-hydroxy-1-(hydroxymethyl) | 4 |
| 2me-2-methyl(tryptophan) | 4 |
| Aba=4-aminobutyric acid | 1 |
| Agp=αamino-3-guanidino-propionic acid | 9 |
| Aminoisobutyric acid | 18 |
| Bip | 36 |
| Dab =2,4-diamino-butyric acid | 2 |
| Dpr-2,3-Diaminopropionic acid | 1 |
| Fatty acid chain | 7 |
| N-linked carbohydrate chains | 2 |
| Gamma peptide linkage | 1 |
| Pyroglutamic acid | 27 |
| Methylation | 27 |
| NMe | 8 |
| Nle=norleucine | 4 |
| PhG=phenylglycine | 1 |
| Reduced amide bonds Ψ(CH2NH) | 33 |
| Reduced carbamate Ψ(CH2OCONH) | 16 |
| Sar= sarcosine | 45 |
| [ψCH2-NH21-22] | 1 |
| tBu=tertiary butyl | 1 |
| αMe | 2 |
| Npa=napthylalanine | 36 |
| Biotinylation | 10 |
| Har=Homoarginine | 6 |
| Orn=Ornithine | 12 |
| Nva=Norvaline | 6 |
| βAla = Beta alanine | 15 |