Welcome to the Help Page of PCPpred

The web server has been meticulously engineered to serve as a publicly accessible platform for the prediction of permeability characteristics of cyclic peptides. This functionality is crucial in the context of drug design and development, as it facilitates the assessment of how these peptides can traverse biological membranes, which is a key determinant of their pharmacokinetic properties. By leveraging advanced computational algorithms and predictive modeling techniques, the web server aims to enhance the efficiency of the drug discovery process, enabling researchers to identify and optimize cyclic peptide candidates with favorable permeability profiles. This, in turn, supports the development of novel therapeutic agents with improved efficacy and safety profiles.

This page offers a concise overview of the various modules available on the server. The following are the primary modules included:

Predict Module

This module enables users to predict the permeability of cyclic peptides. Users can submit either a single peptide in SMILES or MAP format, or multiple peptides in the same formats for analysis.

Predict tutorial image

Design Module

This module allows users to generate custom peptides so that they can be used to predict their permeability. Follow the stepwise illustration below to design the desired peptide and convert it into the required format.

Design tutorial image