The total number of records retrieved from this search are 16. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
IDOV_1924	Virus nameAdenovirus	Virus strainSG600-IL24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding IL24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result90% cell viality after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1925	Virus nameAdenovirus	Virus strainSG600-IL24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding IL24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result70% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1926	Virus nameAdenovirus	Virus strainSG600-IL24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding IL24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result60% cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1927	Virus nameAdenovirus	Virus strainSG600-IL24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding IL24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result30% cell viability after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1936	Virus nameAdenovirus	Virus strainSG600-EGFP	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding EGFP	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing EGFP gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result90% cell viabilty after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1937	Virus nameAdenovirus	Virus strainSG600-EGFP	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding EGFP	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing EGFP gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result80% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1938	Virus nameAdenovirus	Virus strainSG600-EGFP	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding EGFP	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing EGFP gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result80% cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_1939	Virus nameAdenovirus	Virus strainSG600-EGFP	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationAddition of gene encoding EGFP	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing EGFP gene	Source of cell lineInstitute of HCC, Fudan university	Origin of cell lineHuman liver cancer cell line	Cell lineMHCC97L	Concentration of cell line1.0E+3 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result70% cell viability after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce the apoptosis in HCC cell line	Immunogenic effectNA	Clinical trialNA	PMID20872968
IDOV_2562	Virus nameAdenovirus	Virus strainSG600-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result88.2% cell survival after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2563	Virus nameAdenovirus	Virus strainSG600-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result72.3% cell survival after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2564	Virus nameAdenovirus	Virus strainSG600-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result58% cell survival after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2565	Virus nameAdenovirus	Virus strainSG600-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result28% cell survival after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2566	Virus nameAdenovirus	Virus strainSG600-IL-24+IFN	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene and addition of IN	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene and IFN gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result84.3% cell survival after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2567	Virus nameAdenovirus	Virus strainSG600-IL-24+IFN	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene and addition of IN	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene and IFN gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result66.2% cell survival after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2568	Virus nameAdenovirus	Virus strainSG600-IL-24+IFN	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene and addition of IN	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene and IFN gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result54.5% cell survival after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271
IDOV_2569	Virus nameAdenovirus	Virus strainSG600-IL-24+IFN	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of IL-24 gene and addition of IN	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene and IFN gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineMHCC97L	Concentration of cell line1000 cells	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result24% cell survival after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombined therapy increases STAT1, SOCS1 and apoptosis	Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	Clinical trialNA	PMID22569271