The total number of records retrieved from this search are 15. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_649	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	111% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_650	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	102% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_651	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	98% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_652	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	75% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_653	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_654	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	106% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_655	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	95% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_656	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	89% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_657	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	39% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_658	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_694	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_695	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_696	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_697	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	99% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_698	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	1 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486