Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 38. Click on ID to see further detail.
IDOV_887Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDeletion mutant for Gamma 34.5Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue staining and hematocytometerIn-vitro virus concentration0.1 pfu/mlIn-vitro result85% cncer cell killing after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID12788648
IDOV_890Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDeletion mutant for Gamma 34.5Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue staining and hematocytometerIn-vitro virus concentration0.1 pfu/mlIn-vitro result95% cncer cell killing after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID12788648
IDOV_893Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDeletion mutant for Gamma 34.5Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue staining and hematocytometerIn-vitro virus concentration0.01 pfu/mlIn-vitro result80% cncer cell killing after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID12788648
IDOV_896Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDeletion mutant for Gamma 34.5Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayTrypan blue staining and hematocytometerIn-vitro virus concentration0.01 pfu/mlIn-vitro result80% cncer cell killing after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID12788648
IDOV_1141Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationMutant for gamma 34.5, lacZ and alpha 47 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01MOIIn-vitro resultNo cell killing after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID16278413
IDOV_1142Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationMutant for gamma 34.5, lacZ and alpha 47 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1MOIIn-vitro resultNo cell killing after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID16278413
IDOV_1143Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationMutant for gamma 34.5, lacZ and alpha 47 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01MOIIn-vitro result70% cell killing after 4 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID16278413
IDOV_1144Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationMutant for gamma 34.5, lacZ and alpha 47 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1MOIIn-vitro result70% cell killing after 4 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID16278413
IDOV_1260Virus nameAdenovirusVirus strainAxdAdb-3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDouble mutated for E1A and E1B geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineProstate cancer cell lineCell lineDu145Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityAssayMTT assayIn-vitro virus concentration30 MOIIn-vitro resultSurviving cell number reached to 1000Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID18063085
IDOV_2022Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2023Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result100% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2024Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration10 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2025Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration100 MOIIn-vitro result10% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2036Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.125 MOIIn-vitro result60% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2037Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.25 MOIIn-vitro result45% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2038Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.5 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2039Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2040Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration2 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2041Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationvirus in combination with Docetaxel (7.5)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityAssayMTS assayIn-vitro virus concentration2.15 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2042Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (15 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityAssayMTS assayIn-vitro virus concentration4.3 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2043Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (30 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityAssayMTS assayIn-vitro virus concentration8.6 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2044Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (60 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityAssayMTS assayIn-vitro virus concentration17.2 MOIIn-vitro result10% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_2045Virus nameReovirusVirus strainReovirus T3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus strain in combination with Docetaxel (120 nM)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line7.5E+3 cells per wellIn-vitro toxicityAssayMTS assayIn-vitro virus concentration34.4 MOIIn-vitro result10% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus cause increase in apoptosisImmunogenic effectNAClinical trialNAPMID21645351
IDOV_3522Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result95% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3523Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result75% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3524Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3525Virus nameAdenovirusVirus strainAdenovirus ZD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion in E1B55 viral proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3526Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3527Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3528Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3529Virus nameAdenovirusVirus strainAdenovirus GD55Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationGOLPH2 regulated aoncolytic adenovirusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line5000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result20% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID28880012
IDOV_3725Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration0.1 MOIIn-vitro result1% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3732Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell lineNAIn-vitro toxicityNAAssayAbsorbance measurementsIn-vitro virus concentration10 MOIIn-vitro result3% cell viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryVirus induce apoptosis in cancer cellPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3737Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c-rag and gamma negative xenograft for Du145 (2.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor after day 80Mode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_4321Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate carcinomaCell lineDu145Concentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result91.4 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_5068Virus nameAvian orthoreovirusVirus strainARV-PB1Virus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line1.0E+3 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result70% cell viability after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28441762
IDOV_5622Virus nameNewcastle disease virusVirus strainNDV-MK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostate cancer cell lineCell lineDu145Concentration of cell line80% confluencyIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration31 pfuIn-vitro result50% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectInduction of IFN-Gamma productionClinical trialNAPMIDUS7470426
IDOV_5842Virus nameNewcastle disease virusVirus strainNDV-PPMK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman prostae carcinoma cell lineCell lineDu145Concentration of cell line80% confluencyIn-vitro toxicityNAAssayNAIn-vitro virus concentration31 pfuIn-vitro result50% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS8105578