Publications from which the Data has been Curated
This page maintain publications used for compiling fragile sites to build HumCFS.
| Fragile Site | Paper title | PMID |
|---|---|---|
| FRA1A | Chromosomal restructurings and the distribution of chromosome fragile sites in the peripheral blood lymphocytes in a breast cancer patient after cytostatic therapy | 1322577 |
| FRA1B | Disabled-1 is a large common fragile site gene, inactivated in multiple cancer | 18008369 |
| FRA1C | A new folate sensitive fragile site at 1p21.3 | 1865478 |
| FRA1D | A new fragile site at 1p21.3 | 1865478 |
| FRA1E | FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene . | 16556484 |
| FRA1F | First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FA-D2 patients in different stages of the disease | 27625703 |
| FRA1G | Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis | 16981993 |
| FRA1H | Molecular characterization of the human common fragile site FRA1H | 17311248 |
| FRA1I | Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer | 25034695 |
| FRA1J | Global screening and extended nomenclature for 230 aphidicolin- | 20198338 |
| FRA1K | Synergistic effect of aphidicolin and ethanol on the induction of common fragile sites | 3100418 |
| FRA1L | Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones | 20198338 |
| FRA1M | Subregional localization of 14 yeast artificial chromosomes to human chromosome region 1p by fluorescence in situ hybridization | 7736782 |
| FRA2A | Global screening and extended nomenclature for aphidicolin induced fragiule site | 20198338 |
| FRA2B | FRA2B is distinct from inverted telomere repeat arrays at 2q13 | 1572659 |
| FRA2C | The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers | 21258086 |
| FRA2D | Global screening and extended nomenclature for aphidicolin induced fragile site | 20198338 |
| FRA2E | Epstein-Barr virus is integrated between REL and BCL-11A in American Burkitt lymphoma cell line | 15241441 |
| FRA2F | Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma | 14562053 |
| FRA2G | Characterization of the human common fragile site FRA2G | 12620385 |
| FRA2H | Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats | 22476624 |
| FRA2I | Fragile sites and human disease | 17567780 |
| FRA2J | A new human hypervariable locus (K29) maps to the q37.3 region of chromosome 2 and reveals a fingerprint | 1840562 |
| FRA2K | Fragile sites and human disease | 17567780 |
| FRA2L | A heritable folate-sensitive fragile site on chromosome 2p 11.2 | 2254969 |
| FRA2S | Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 - Molecular characterization of FRA2H and localization of a new CFS FRA2S | 20851513 |
| FRA3A | DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes | 6430783 |
| FRA3B | Evidence that instability within the FRA3B region extends four megabases | 12483524 |
| FRA3C | Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site | 8406484 |
| FRA3D | Fragile sites and human disease | 17567780 |
| FRA4A-D | Fragile sites and human disease | 17567780 |
| FRA4E | Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1 | 15286716 |
| FRA5A & B | Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis | 16981993 |
| FRA5C | SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma | 14670176 |
| FRA5D & E | Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma | 14562053 |
| FRA5G | Common Fragile Sites and Cancer | 15650228 |
| FRA5H | FRA5H: A New Common Fragile Site on Chromosome 5q11.2-12 | 123911288 |
| FRA6A & B | An integrated map of human chromosome 6p23 | 8750194 |
| FRA6C | Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites | 11085503 |
| FRA6D | New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine | 2579891 |
| FRA6H | Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22 | 17290399 |
| FRA7A,C, D & F | Genetic markers on chromosome 7 | 3290488 |
| FRA7B | Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region | 20804921 |
| FRA7E | Molecular basis for expression of common and rare fragile sites | 14517285 |
| FRA7G | Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2 | 10950921 |
| FRA7H | Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site | 9653154 |
| FRA7I | Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I | 12393800 |
| FRA7J | The molecular basis of common and rare fragile sites | 16236432 |
| FRA7K | Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints. | 17039484 |
| FRA8A | Report of the committee on chromosome rearrangements in neoplasia and on fragile sites | 3864602 |
| FRA8B & C | Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma | 14562053 |
| FRA8D | Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13 | 15381365 |
| FRA8E | A distamycin A-inducible fragile site, FRA8E, located in the region of the hereditary multiple exostoses gene, is not involved in HPV16 DNA integration and amplification | 9460496 |
| FRA9A & B | Population cytogenetics of folate-sensitive fragile sites,Autosomal rare fragile sites | 2714776 |
| FRA9C & F | New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine | 2579891 |
| FRA9D | Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma | 14562053 |
| FRA9E | Characterization of the common fragile site FRA9E and its potential role in ovarian cancer | 12555072 |
| FRA9G | Novel aphidicolin-inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene | 17668870 |
| FRA10A | Exact localization of several fragile sites remains uncertain. The example of fra(10) sensitive to folate | 3879149 |
| FRA10B | Heritable fragile sites on human chromosomes. IX. Population cytogenetics and segregation analysis of the BrdU-requiring fragile site at 10q25 | 7124730 |
| FRA10C | New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine | 2579891 |
| FRA10D | Common fragile sites, extremely large genes, neural development and cancer | 16221525 |
| FRA10E | The molecular basis of common and rare fragile sites | 16236432 |
| FRA10F | Common fragile sites: genomic hotspots of DNA damage and carcinogenesis | 23109895 |
| FRA10G | DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells | 20101222 |
| FRA11A | The molecular basis of the folate-sensitive fragile site FRA11A at 11q13 | 18160775 |
| FRA11B & G | Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions | 17063465 |
| FRA11C & D | The role of viral integration in the development of cervical cancer | 15771901 |
| FRA11E | Fragile sites are preferential targets for integrations of MLV vectors in gene therapy | 16511518 |
| FRA11H | Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites | 23852038 |
| FRA11I | A new rare distamycin A-inducible fragile site, fra(11) (p15.1), found in two acute nonlymphocytic leukemia (ANLL) patients with t(7;11)(p15-p13;p15) | 3169734 |
| FRA12A | Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A | 8833161 |
| FRA12B | Deletion at Fragile Sites is a Common and Early Event in Barrett’s Esophagus | 20647332 |
| FRA12C | A BrdU-requiring fragile site on chromosome 12 | 3338802 |
| FRA12D & E | A male with the folate-sensitive rare fragile site at 12q24.1 | 14526166 |
| FRA13A | The neurobeachin gene spans the common fragile site FRA13A | 16244873 |
| FRA13B,C & D | Forgotten fragile sites and related phenomena | 14526168 |
| FRA13E | Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22 | 17290399 |
| FRA14B | Gephyrin and neurexin 3 are new large common fragile site (cFS) genes frequently rearranged in different human cancers | 100769 |
| FRA14C | Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma | 14562053 |
| FRA15A | RORA, a large common fragile site gene, is involved in cellular stress response | 16462772 |
| FRA16A | Mapping the short arm of human chromosome 16 | 2714795 |
| FRA16B | Population cytogenetics of rare fragile sites | 3338799 |
| FRA16C | The molecular basis of common and rare fragile sites | 16236432 |
| FRA16D | The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations | 11013073 |
| FRA16E | Distamycin A-inducible fragile sites and cancer proneness | 3409200 |
| FRA17A | Population cytogenetics of folate-sensitive fragile sites. II. Autosomal rare fragile sites | 2714776 |
| FRA17B | Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites | 11085503 |
| FRA18 A & B | Are common fragile sites merely structural domains or highly organized functional units susceptible to oncogenic stress | 25238782 |
| FRA18C | FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage | 17475918 |
| FRA19A | New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine | 2579891 |
| FRA19B | Fragile 19p13 in a family with mental illness | 3568428 |
| FRA20A & B | Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics | 453198 |
| FRA21A | Systematic screening of chromosome 18 for loss of heterozygosity in esophageal squamous cell carcinoma | 10326596 |
| FRA22A | Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1 | 1424804 |
| FRA22B | Common fragile sites, extremely large genes, neural development and cancer | 16221525 |
| FRAXA | A common fragile site at Xq27: theoretical and practical implications | 3358421 |
| FRAXB & D | Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells | 11746990 |
| FRAXE | Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation | 8334699 |
| FRAXF | The identification of a third fragile site, FRAXF, in Xq27--q28 distal to both FRAXA and FRAXE | 8499907 |