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Details of CPPsite entry with Sequence rrrrrrrrr
Primary information
PEPTIDE SEQUENCErrrrrrrrr
CPPsite ID 2100, 2535, 2939, 1043, 1814, 1815, 1816,
PEPTIDE NAME9R, RVG-9DR, H3, D-R9, r9, r9, r9
CHIRALITYD, D, D, D, D, D, D
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear, Linear, Linear
SOURCESynthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic
CATEGORYNA, Cationic, NA, Cationic, Cationic, Cationic, Cationic
SUB CELLULAR LOCALIZATIONCytoplasm, NA, NA, Probably cytoplasm and nucleus, Plasma membrane bound, Plasma membrane bound, Cytoplasm and nucleoli
N-TERMINAL MODIFICATIONBiotinylation, Conjugated with RVG, Free, Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer, Conjugation with rhodamine B, Conjugation with rhodamine B, Conjugation with rhodamine B
C-TERMINAL MODIFICATIONFree, Conjugation with siFITC complex, Free, Free, Amidation, Amidation, Amidation
CHEMICAL MODIFICATIONNA, NA, NA, NA, NA, NA, NA
UPTAKE EFFICIENCYLow, Higher uptake efficiency, NA, High (relative to both Tat (49-57) and R7), 53% that of R9, 46% that of R9, Comparable to R9
PROPOSED UPTAKE MECHANISMNA, NA, NA, Probably non-endocytic pathway, Unknown, Unknown, Unknown
INVITRO/INVIVOIn vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro
CELL LINEHuman tongue squamous cell carcinoma (SCC) CAL 27 and SCC-25, Neuro2a, Jurkat cells, C166-eGFP cells, Jurkat, HeLa, MC57, Jurkat
In VIVO MODELNA, NA, NA, NA, NA, NA, NA
CARGONucleic acid (siRNA), Nucleic acid (siRNA), Nucleic acid (siRNA), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein)
PMID24019920, 25544044, 11087855, 21867915, 21867915, 21867915
PATENTUnknown, Unknown, WO 2011/020188 A1, US 6593292, Unknown, Unknown, Unknown
Tertiary Structure
(Technique)		2100 (PEPstrMOD), 2535 (PEPstrMOD), 2939 (PEPstrMOD), 1043 (PEPstrMOD), 1814 (PEPstrMOD), 1815 (PEPstrMOD), 1816 (PEPstrMOD),