Details of CPPsite entry with Sequence rqikiwfqnrrmkwkk |
Primary information | |
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PEPTIDE SEQUENCE | rqikiwfqnrrmkwkk |
CPPsite ID | 2162, 2451, 2900, 1092, 1822, 1823, |
PEPTIDE NAME | Penetratin, Penetratin, D-Penetratin, D form of pAntpHD (43-58), Penetratin {pAntp-(43-58)}, Penetratin {pAntp-(43-58)} |
CHIRALITY | D, D, D, D, D, D |
LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear |
SOURCE | Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived |
CATEGORY | Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Amphipathic, Amphipathic, Amphipathic |
SUB CELLULAR LOCALIZATION | NA, NA, NA, Cytoplasm and nucleus, Vesicles and membrane bound, Membrane bound |
N-TERMINAL MODIFICATION | Free, Free, Free, Biotinylation, Conjugation with fluorescein, Conjugation with fluorescein |
C-TERMINAL MODIFICATION | Free, Free, Free, Amidation, Amidation, Amidation |
CHEMICAL MODIFICATION | NA, NA, NA, NA, NA, NA |
UPTAKE EFFICIENCY | Higher than control insulin and L penetratin, Lower degradation rate, NA, Similar to (pAntp) (43-58), Unknown, Unknown |
PROPOSED UPTAKE MECHANISM | NA, Energy-independent pathway, NA, Non-receptor mdiated endocytic pathway, Unknown, Unknown |
INVITRO/INVIVO | In vivo, In vitro, In vivo, In vitro, In vitro, In vitro |
CELL LINE | NA, None, NA, Cortical striatal cells, HeLa, MC57 |
In VIVO MODEL | Seven weeks old male ddY mice, male Sprague Dawley rats, Male ddY mice, Male ddY mice, NA, NA, NA |
CARGO | Protein (Insulin), Protein (Insulin), Protein (Insulin), Biotin, Fluorophore (fluorescein), Fluorophore (fluorescein) |
PMID | 24973720, 24973720, 25445695, 8663410, 21867915, 21867915 |
PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown |
Tertiary Structure (Technique) | 2162 (PEPstrMOD), 2451 (Experimentally determined structure from PDB), 2900 (PEPstrMOD), 1092 (Experimentally determined structure from PDB), 1822 (Experimentally determined structure from PDB), 1823 (Experimentally determined structure from PDB), |