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Details of CPPsite entry with Sequence RRRRRRRR-c(RGDfK)
Primary information
PEPTIDE SEQUENCERRRRRRRR-c(RGDfK)
CPPsite ID 2498,
PEPTIDE NAMER8-RGD-lipo
CHIRALITYModified
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONConjugation with cyclic RGD
CHEMICAL MODIFICATIONCysteine modified octa-arginine conjugated to the branch of lysine
UPTAKE EFFICIENCYHigher uptake efficiency
PROPOSED UPTAKE MECHANISMEnergy-dependent properties of integrin receptor mediated endocytosis
INVITRO/INVIVOIn vitro and in vivo
CELL LINEMurine glioma cells (C6),bEnd.3 cells and HeLa
In VIVO MODELBalb/c mice
CARGONanoparticle (CFPE-labeled liposomes), RGD
PMID24651033
PATENTUnknown
Tertiary Structure
(Technique)		Not Predicted),