Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence RRRRRR |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | RRRRRR |
| CPPsite ID | 2532, 2533, 1032, |
| PEPTIDE NAME | V2, V2R, R6 |
| CHIRALITY | L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear |
| SOURCE | Synthetic, Synthetic, Synthetic |
| CATEGORY | Cationic, Cationic, Cationic |
| SUB CELLULAR LOCALIZATION | Cytoplasm and Nucleus, NA, Cytoplasm and nucleus |
| N-TERMINAL MODIFICATION | Conjugated to FITC modified folding domain via ?-alanine–glycine– glycine linker, Conjugated to FITC modified folding domain via ?-alanine–glycine– glycine linker, Conjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer |
| C-TERMINAL MODIFICATION | Amidation, Amidation, Free |
| CHEMICAL MODIFICATION | NA, NA, NA |
| UPTAKE EFFICIENCY | V2 has a stronger preference to accumulate within the nuclear bodies that contain a high con- centration of DNA, Cells indicates a lack of cellular uptake of V2R, Medium (relative to Tat (49-57)) |
| PROPOSED UPTAKE MECHANISM | NA, NA, Probably non-endocytic pathway |
| INVITRO/INVIVO | In vitro, In vitro, In vitro |
| CELL LINE | NIH-3T3 Swiss mice fibroblasts and Jurkat E6 cells, NIH-3T3 Swiss mice fibroblasts and Jurkat E6 cells, Jurkat |
| In VIVO MODEL | NA, NA, NA |
| CARGO | Peptide (FITC labelled peptide), Peptide (FITC labelled peptide), Fluorophore (fluorescein) |
| PMID | 25524829, 25524829, 11087855 |
| PATENT | Unknown, Unknown, US 6593292 |
| Tertiary Structure (Technique) | 2532 (PEPstrMOD), 2533 (PEPstrMOD), 1032 (PEPstrMOD), |