Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence RPARPAR |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | RPARPAR |
| CPPsite ID | 2045, 2046, 2047, 2048, 2049, 2050, 2958, |
| PEPTIDE NAME | PA 1, PA 2, PA 3, PA 4, PA 5, PA 8, CendRP |
| CHIRALITY | L, L, L, L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear, Linear |
| SOURCE | Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic |
| CATEGORY | Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, NA |
| SUB CELLULAR LOCALIZATION | Vesicles, Vesicles, Vesicles, Vesicles, Vesicles, Vesicles, NA |
| N-TERMINAL MODIFICATION | Free, Di-palmitilysation, Di-palmitilysation, Free, Free, Di-palmitilysation, Conjugation with 5(6)-Carboxyfluorescein |
| C-TERMINAL MODIFICATION | Free, Free, Amidation, Free, Amidation, Free, Free |
| CHEMICAL MODIFICATION | NA, NA, NA, NA, NA, NA, NA |
| UPTAKE EFFICIENCY | NA, Higher association compared to peptide 1, Similar for RPARPAR PAs with amidated C-terminus, Higher association compared to peptide 1, Similar for RPARPAR PAs with amidated C-terminus, NA, Low |
| PROPOSED UPTAKE MECHANISM | Clathrin- independent Carriers (CLIC) pathway, Clathrin- independent Carriers (CLIC) pathway, Clathrin- independent Carriers (CLIC) pathway, Clathrin- independent Carriers (CLIC) pathway, Clathrin- independent Carriers (CLIC) pathway, Clathrin- independent Carriers (CLIC) pathway, NA |
| INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vivo |
| CELL LINE | PPC-1 and M21, PPC-1 and M21, PPC-1 and M21, PPC-1 and M21, PPC-1 and M21, PPC-1 and M21, NA |
| In VIVO MODEL | NA, NA, NA, NA, NA, NA, Adult zebrafish |
| CARGO | Fluorophore (Rhodamine), Fluorophore (Rhodamine), Fluorophore (Rhodamine), DSP-PEG2000 and Fluorophore (Rhodamine), DSP-PEG2000 and Fluorophore (Rhodamine), Fluorophore (Oregon514 dye), Fluorophore (5-Carboxyfluorescein) |
| PMID | 23349939, 23349939, 23349939, 23349939, 23349939, 23349939, 25894337 |
| PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown |
| Tertiary Structure (Technique) | 2045 (PEPstrMOD), 2046 (PEPstrMOD), 2047 (PEPstrMOD), 2048 (PEPstrMOD), 2049 (PEPstrMOD), 2050 (PEPstrMOD), 2958 (PEPstrMOD), |