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Details of CPPsite entry with Sequence RKKARQRRR
Primary information
PEPTIDE SEQUENCERKKARQRRR
CPPsite ID 1017,
PEPTIDE NAMEAla52 substitution mutant of Tat (49-57)
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONProbably cytoplasm and nucleus, nucleolus
N-TERMINAL MODIFICATIONConjugation with fluorescein with 6-aminohexanoic acid (Ahx) spacer
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYLow (relative to Tat (49-57))
PROPOSED UPTAKE MECHANISMProbably non-endocytic pathway
INVITRO/INVIVOIn vitro
CELL LINEJurkat
CARGOFluorophore (fluorescein)
PMID11087855
PATENTUS 6593292
Tertiary Structure
(Technique)		1017 (PEPstrMOD),