Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence GRKKRRQRRRPPQC |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | GRKKRRQRRRPPQC |
| CPPsite ID | 2666, 1438, 1740, 1831, |
| PEPTIDE NAME | TAT, Tat ARM, PN173 (SEQ ID NO: 36), HIV-1 Tat (48-60) |
| CHIRALITY | L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear |
| SOURCE | Synthetic, Protein derived, Synthetic, Protein derived |
| CATEGORY | Cationic and amphipathic, Cationic, Unknown, Cationic |
| SUB CELLULAR LOCALIZATION | NA, Cytoplasm and nucleus, Unknown, Only punctate distribution (vesicles) |
| N-TERMINAL MODIFICATION | NA, Conjugation with rhodamine B, Free, Free |
| C-TERMINAL MODIFICATION | Amidation, Amidation, Amidation, Conjugation with Alexa 488 at glycyl cysteine sequence |
| CHEMICAL MODIFICATION | NA, NA, NA, NA |
| UPTAKE EFFICIENCY | Accumulations were only slightly different from that of the control GC peptide in tumors, Unknown, Unknown, Unknown |
| PROPOSED UPTAKE MECHANISM | NA, Non-endocytic pathway, Unknown, Endocytic pathway (Macropinocytosis) |
| INVITRO/INVIVO | In vivo, In vitro, In vitro, In vitro |
| CELL LINE | NA, HeLa, 9 L/LacZ cells, CHO-K1, HeLa and Jurkat |
| In VIVO MODEL | Tumor-xenografted nude mice, NA, NA, NA |
| CARGO | Fluorophore (Alexa660), Fluorophore (rhodamine), Nucleic acid (siRNA), Fluorophore (Alexa-488) |
| PMID | 22285548, 12119035, 19707187 |
| PATENT | Unknown, US 20040132970, US 20060035815, US 20040132970 |
| Tertiary Structure (Technique) | 2666 (PEPstrMOD), 1438 (PEPstrMOD), 1740 (PEPstrMOD), 1831 (PEPstrMOD), |