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This page gives details of CPPsite entry with ID 2672
Primary information
CPPsite ID2672
PEPTIDE SEQUENCErrrrrrrrGC
PEPTIDE NAMEr8
CHIRALITYD
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYMarked accumulation of r8 was observed in the tumor xenografts, 3 times more than L form and nine times higher than that of the control GC peptide
INVITRO/INVIVOIn vivo
In VIVO MODELTumor-xenografted nude mice
CARGOFluorophore (Alexa660), Small molecule drug (doxorubicin)
PMID22285548
PATENTUnknown
LENGTH10
Secondary StructureCGGGGGCCCC
SMILESN[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)N[C@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CS)C(=O)N
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)